The evolving story of apolipoprotein L1 nephropathy: the end of the beginning Reviews Published on 2022-02-252022-10-05 Journal: Nature reviews. Nephrology [Category] 유전자 메커니즘, [키워드] Activation African African American alleles alteration APOL1 Cell Chronic kidney disease clinical trials coding variant cofactor Culture current develop dysfunction ENCODE Endoplasmic reticulum HIV-1 hypertension individual inflammasome activation Kidney disease mitochondrial dysfunction molecular nephropathy progression promoter Protein responsible resulting risk risk allele Stress syndrome therapy variant variants viral infection [DOI] 10.1038/s41581-022-00538-3 [Article Type] Reviews
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severityMini review Published on 2022-02-012022-10-05 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, [키워드] accelerate activated Activation Affect Comorbidities Comorbidity condition correlated COVID-19 COVID-19 disease severity creating Critical death deleterious effect disease disease severity downstream dysregulated dysregulation event immune immune component immune response Immunity individual Infection inflammasome activation Inflammatory innate immune responses Interaction knowledge NLRP3 NLRP3 inflammasome Occurrence pathophysiology required risk factor Risk factors severe COVID-19 severity of COVID-19 Therapeutic approach Therapeutics Treatment underlying disorders [DOI] 10.1016/j.micinf.2021.104913 [Article Type] Mini review
Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 − Monocytes From COVID-19 PatientsCOVID-19 환자의 CD14 높은 CD16- 단핵구에서 지속적인 산화 스트레스 및 염증 활성화Immunology Published on 2022-01-142022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] addition caspase caspase-1 caused CD14 CD14highCD16− monocytes CD16 Cell contribute coronavirus coronavirus disease correlated COVID-19 dependent on disease severity displaying enrichment evidenced hallmark healthy controls hyperinflammation Hyperinflammatory IL-1β immunopathology implicated in vitro Inflammasome inflammasome activation lipid peroxidation Mild mitigate mitochondrial monocyte Monocytes NLRP3 NLRP3 inflammasome outcome outcomes oxidative oxidative stress oxidative stress response pathway Patient persistent response SARS-CoV-2 secretion severe COVID-19 patient severe COVID-19 patients signaling pathway Stress stress response stress responses Superoxide therapy [DOI] 10.3389/fimmu.2021.799558 PMC 바로가기 [Article Type] Immunology
Inflammasome activation in neutrophils of patients with severe COVID-19Research article Published on 2022-01-062022-10-05 Journal: Blood advances [Category] COVID19(2023년), SARS, 변종, [키워드] Activation acute respiratory syndrome ASC coronavirus correlation COVID-19 COVID-19 patient demonstrated engage fluorescent form human disease implicated induce Inflammasome inflammasome activation Inflammation leukocytes Macrophage mice Microscopy microtubule organizing center monocyte NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils NLRP3 inflammasome nuclear nuclei nucleus pathogenesis of COVID-19 Patient Peripheral blood positive Protein reporter Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient stimulated the cytokine storm tracheal aspirate [DOI] 10.1182/bloodadvances.2021005949 [Article Type] Research article
Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope proteinArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Activation approach Coronaviruses COVID-19 cultured macrophage Cytokine storm drug E protein early stage Effect envelope Evidence examined expression Host human macrophages IL-18 IL-1β immunology Infection Inflammasome inflammasome activation Inflammatory response initial LPS lung Macrophage Macrophage infiltration mechanism mice Microbiology murine NLRP3 inflammasome Pathogenesis Patient priming Protein pulmonary inflammation reduced response SARS-CoV-2 disease Stage suggested suppress suppressed targeting therapy transfected with treated Treatment Vaccine Viral RNA virulence [DOI] 10.1038/s41598-021-04133-7 PMC 바로가기 [Article Type] Article
Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic MoleculesReview Published on 2021-12-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence Activation approach clinical outcomes clinical trial complications Consequences COVID-19 COVID-19 patient COVID-19 patients Critical delivery dependent on Drug efficacy dysregulation effective Efficacy immune dysregulation Inflammasome inflammasome activation mechanisms microRNA modulating Molecular targets molecule morbidity NLRP3 NLRP3 inflammasome non-coding RNA Non-coding RNAs Numerous pathogenesis of COVID-19 potential therapeutic target pro-inflammatory cytokine pro-inflammatory mediator reduce Research RNA RNA interference RNAs significantly targeting the cytokine storm therapeutic agent Therapeutic molecule Treatment Treatment strategies Vaccines variants of SARS-CoV-2 vector with COVID-19 worsened [DOI] 10.3390/biomedicines9121823 PMC 바로가기 [Article Type] Review
Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19Review Published on 2021-11-172022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 adaptive Bacterial cellular damage clinical trial COVID-19 COVID-19 pathogenesis cytokine release cytoplasmic dosage Effect Effectiveness Evidence Ex vivo forms highlighting host’s immune system Human immune response immune systems immunomodulatory implicated in vivo indicate inflammasome activation inflammasomes inflammation markers inflammatory conditions inflammatory process Invasion mammalians management metabolites microbial infection modulate multiprotein complex NLRP3 NLRP3 activation NLRP3 inflammasome pathophysiological mechanism Potential preclinical study presenting probiotic bacteria Probiotics protein 3 Regulating Regulation Replication Research SARS-CoV-2 SARS-COV-2 infection shown strain trials virus with COVID-19 [DOI] 10.3390/microorganisms9112376 PMC 바로가기 [Article Type] Review
Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein자주 볼 수있는 SARS-COV-2 ORF3A 횡단 단백질의 노출 된 N 및 C 말단 영역을 인식하는 단일 클론 인간 항체Communication Published on 2021-11-022022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] activities activity Analysis anti-ORF3a mAbs antibody antigens apoptosis induction autophagy binding affinities binding affinity C terminal calcium cellular complex conformation COVID-19 infections cytosolic diagnostic Disruption disturbance domain enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes evaluate evaluated Extracellular fluorescent fluorescent microscopy full-length generate homeostasis Human infected cell infected cells inflammasome activation involved linear Microscopy modulate monoclonal antibody N Terminal naïve ORF3a ORF3a protein pathophysiological peptide peptides performed prognostic biomarker Prognostic biomarkers Protein Proteins protocols recombinant antibodies Region SARS-CoV-2 SARS-CoV-2 infected cells selected surface plasmon surface plasmon resonance terminal therapeutic potential transfected cell transmembrane transmembrane protein viroporin western blot [DOI] 10.3390/v13112201 PMC 바로가기 [Article Type] Communication
Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative ImmunityReview Published on 2021-10-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response Autoimmunity autoinflammatory disease characteristic component COVID-19 COVID-19 infection cytokine Cytokines Diseases dysregulation extreme generate hyperinflammation immune system inflammasome activation Inflammation Innate macrophages manifestation NLRP3 overlap Pathogenesis pathologic condition Pathologies pharmacological treatment responses target the cytokine storm therapeutic target triggering White blood cells [DOI] 10.3390/ijms222011241 PMC 바로가기 [Article Type] Review
Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in MacrophagesArticle Published on 2021-10-152022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activated Activation analyzed cell death cleavage cleaved component CRISPR-Cas9 detect different diseases Evidence gasdermin D glycoprotein GSDMD hallmark HCMV HCV IL-1β IL-1β immune response indicated induce inflammasome activation innate immune responses innate immune system Innate immunity knowledge Lytic Macrophage macrophages mechanism NLRP3 NLRP3 inflammasome pyroptosis required responsible secretion Support tested THP-1 Trigger triggers Vaccine development variety viral entry viral glycoprotein viral glycoproteins viral pathogen viral pathogenesis viral pathogens widespread [DOI] 10.3390/v13102076 PMC 바로가기 [Article Type] Article