inflammatory signaling – Page 2 – Communicable Diseases Research

Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19

SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할

Review

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료법,

Psychological Symptoms in COVID-19 Patients: Insights into Pathophysiology and Risk Factors of Long COVID-19

Review

Published on 2022-01-022022-10-28
Journal: Biology [Category] COVID-19,

[키워드] ACE-2 acute respiratory syndrome affecting alleviate angiotensin-converting enzyme 2 Anxiety appear articles association Brain Cell Central nervous system CNS complex Complication concerning consequence Consequences coronavirus COVID-19 COVID-19 infection Depression disorders epithelial cells etiology Evidence Factor Factors female gender General population Health immune immune inflammatory signaling immune response implication IMPROVE include Infection inflammatory signaling insight Long mechanism mechanisms mental health MERS Middle East Mounting multifactorial Neuropsychiatric Outbreaks Post-traumatic stress disorder Post-traumatic stress disorder (PTSD) presenting Prevalence prevalence rate Psychiatric psychiatric disorder Psychological psychological symptom psychological symptoms psychotropic medications PTSD receptor risk risk factor Safe SARS-CoV-2 shown simple survivor Survivors syndrome the SARS-CoV-2 therapeutic intervention therapeutic option these symptoms Treatment Variation
[DOI] 10.3390/biology11010061 PMC 바로가기 [Article Type] Review

Niclosamide for Covid-19: bridging the gap

Covid-19용 니클로사미드: 격차 해소

Review

Published on 2021-12-012022-09-11
Journal: Molecular biology reports [Category] SARS, 치료제,

[키워드] acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme anthelminthic Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Antiviral antiviral activities Antiviral effect antiviral effects biological processes clinical outcomes clinical study clinical trial clinical trials Concentration concerning COVID-19 COVID-19 severity Cytokines Cytopathic effect Direct disease distress Effect endosomal pH enzyme Google Scholar homeostasis immune in vivo Inflammasome inflammatory signaling inhibit interruption mandatory maturation mechanism modulate modulating mTOR mTOR signaling NCL neutralization NF-κB niclosamide NLRP3 NLRP3 inflammasome oral bioavailability oxidative phosphorylation pandemic pathway Patient pleiotropic pro-inflammatory cytokines Prospective protective role reduce reducing Regulatory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection Science Science Direct serum severity signaling pathway suppression therapeutic therapy treat viral proliferation Viral protein was done Web of Science
[DOI] 10.1007/s11033-021-06770-7 PMC 바로가기 [Article Type] Review

Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives

Review Article

Published on 2021-10-042022-10-29
Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Affect Alveolar Type II Anti-inflammatory antiapoptotic antioxidant Antioxidative Apoptosis caused cell membrane cellular cellular organelles Clinical effect clinical study complement confirmed case contribute Coronavirus-2 COVID-19 COVID-19 complication death deaths demonstrated Diseases Effect ENhance etiology Gas exchange global pandemic homeostasis hydrogen hypoxia IMPROVE induce Infection Inflammation Inflammatory inflammatory signaling Intervention investigated mechanism mechanisms Mitochondrial function molecular Multisystem organ failure outcomes oxidative stress pathogenesis of COVID-19 pathological response pathway penetrate Pneumocytes Research SARS-CoV-2 significantly suppress Treatment widespread
[DOI] 10.1155/2021/5513868 PMC 바로가기 [Article Type] Review Article

Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin

국소 차아염소산(HOCl)은 UV에 노출된 SKH-1 고위험 마우스 피부에서 염증성 유전자 발현 및 종양 발생 진행을 차단합니다

Article

Published on 2021-09-012022-09-11
Journal: Redox Biology [Category] SARS, 유전자 메커니즘,

[키워드] addition Analysis AP-1 atopic dermatitis bioluminescent block blocked Cancer Carcinogenesis clinical evidence combinations condition consequence COVID-19 pandemic drinking water elicited environmental exposure example exposure to finding Gene Expression Gene expression analysis high risk HMOX1 HOCl hypochlorous acid Il19 Immunohistochemical analysis Inflammation Inflammatory inflammatory signaling investigated luciferase mice mimicking modulation molecular murine model NOS2 observation oxidative stress oxidizing Pathway-focused gene expression profiling performed progression psoriasis PTGS2 public health Radiation reconstructed released skin skin cancer Solar Solar UV radiation. Srxn1 Stress stress response subsequent Support suppressed suppression Swimming pool therapeutic therapeutic intervention These data TLR4 Topic topical transgenic ultraviolet water
[DOI] 10.1016/j.redox.2021.102042 PMC 바로가기 [Article Type] Article

The signal pathways and treatment of cytokine storm in COVID-19

Review Article

Published on 2021-07-072022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] 변종, 비임상, 임상,

[키워드] acute respiratory distress affected Antibody-dependent enhancement capillary leak syndrome cells Characteristics characterized clinically COVID-19 COVID-19 pathogenesis current cytokine Cytokine storm death develop disease Disseminated intravascular coagulation downstream dysregulation effective Evidence Fever help IFN-I immune immunopathological immunopathology Infectious disease Infectious diseases Inflammatory diseases inflammatory signaling Intervention involved lymphopenia macrophages monocyte multiorgan failure pandemic pathway Pathways physically poor prognosis pro-inflammatory cytokine proportion receptor reduced Research responsible resulting secreted severe cases Signaling signaling pathway suggested Symptom syndrome tissue Treatment treatment strategy type I interferon
[DOI] 10.1038/s41392-021-00679-0 PMC 바로가기 [Article Type] Review Article

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

Research Article

Published on 2021-06-302022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] Activation Affect Antiviral antiviral signaling biochemical Blood Caco2 cells Case series CCL-2 cellular Concentration contribute COVID-19 CPE, cytopathic effect cytokine release Cytokine release syndrome death driver DSF, dynamic scanning fluorimetry eosinophils explain expressed expression expression level Famotidine FRET, fluorescence resonance energy transfer functional GERD, gastroesophageal reflux disease H2 receptor Histamine IL6 Inflammation inflammatory mediator Inflammatory responses inflammatory signaling inhibit intubation IRF3 management Mast cells MC, mast cell molecular basis Neutrophils NF-κB pathway observation outcome PAMP, Pathogen-Associated Molecular Pattern patients hospitalized patients with COVID-19 pharmacokinetic PKA, protein kinase A precipitate Protease activity reduce reduced reduced risk retrospective cohort SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection SARS-CoV-2-infected cell SARSCoV-2, severe acute respiratory syndrome coronavirus 2 Signaling symptom resolution TLR3 TLR3, toll-like receptor 3 Toll-like receptor Toll-like receptor 3 treated Treatment Vaccinations viral replication with COVID-19
[DOI] 10.1016/j.jbc.2021.100925 PMC 바로가기 [Article Type] Research Article

Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Review

Published on 2021-06-112022-11-01
Journal: Foods [Category] COVID-19,

Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2

Review Article

Published on 2021-06-042022-10-31
Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] COVID-19, MERS, SARS,

[키워드] ACE inhibitors ACE2 ACE2 expression ACE2 receptor age Angiotensin receptor blockers Angiotensin-converting enzyme battle Betacoronavirus caused Cell cellular entry Cerebrovascular disease chronic obstructive clinical Colon Comorbidity COPD Coronary heart disease COVID-19 COVID-19 patient COVID-19 therapeutics diabetes Enterocyte expression Factor hypertension infect Infection inflammatory signaling knowledge management master regulator outcome pandemic pneumocyte positive primary site pulmonary disease regulated Regulation respiratory tract SARS-CoV-2 SARS-CoV-2 infections smoking the SARS-CoV-2 virus Trial Tuberculosis
[DOI] 10.1155/2021/9939929 PMC 바로가기 [Article Type] Review Article

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

Research Article

Published on 2021-04-032022-10-30
Journal: The Journal of Biological Chemistry [Category] Coronavirus,

[키워드] Activation Alpha antibody AOSD, adult-onset Still's disease bind blockade Candida albican characterized complex COVID-19 COVID-19 patient COVID-19 patients cultures Cytokine storm Diseases downstream DSS, dextran sodium sulfate elevated exhibiting high mortality human cell lines humanized IBD, Inflammatory bowel disease IFNγ IFNγ IL-1 IL-1 receptor 7 (IL-1R7) IL-18 IL-18, interleukin-18 IL-6 Inflammation inflammatory signaling inhibited initiate Interleukin-18 interleukin-18 (IL-18) LPS macrophage activation syndrome macrophage activation syndrome (MAS) MAS, macrophage activation syndrome modulate monoclonal mononuclear cell NFκB PBMC, peripheral blood mononuclear cell PBMCs Peripheral blood Proinflammatory cytokine receptor recruitment reduce reduced resulting severe disease severity of COVID-19 sHLH, secondary hemophagocytic lymphohistiocytosis Signaling significantly suppressed Symptoms systemic and local systemic hyperinflammation therapeutic therapeutic strategy TIR, Toll-IL-1 receptor TNFα TNSB, trinitrobenzoic sulfonic acid Whole blood
[DOI] 10.1016/j.jbc.2021.100630 PMC 바로가기 [Article Type] Research Article