Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspectiveSARS-CoV-2의 부착으로 차가버섯 테르페노이드의 간섭; 실리코 관점에서Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] 501.V2 affinities approach binding affinities binding affinity binding energy can be used cancer cell Cancer cells Chaga terpenoids compounds COVID-19 domain drug finding Glucose GRP78 host cell host cell receptor HSPA5 in silico in vivo in-silico inhibitor interfere Interference investigator MM-GBSA molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations NAMD pandemic peptide performed Perspective Protein receptor receptors Recognition reported Result SARS-CoV-2 SARS-CoV-2 receptor targeting terpenoid tested the binding affinity the SARS-CoV-2 therapeutic variants variants of SARS-CoV-2 was tested [DOI] 10.1016/j.compbiomed.2022.105478 PMC 바로가기 [Article Type] Article
Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids동시 분광형광법을 사용한 COVID-19 치료를 위한 FDA 승인 약물인 favipiravir 및 hydroxychloroquine의 정량 분석: 제약 제제 및 생물학적 유체에 적용Article Published on 2022-06-012022-09-11 Journal: Luminescence : the journal of biological and chemi [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acetate acute respiratory syndrome Analysis applied approach biological fluid biological fluids buffer cause caused condition contagious coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 country COVID-19 Detection limit diluent drug Drug administration Ethanol exhibited Favipiravir FDA-approved drug fluorescence intensity food harmonization Healthcare systems human plasma sample human plasma samples Hydroxychloroquine identify information Interference International Conference investigated limit limits medications Pharmaceutical Preparation pharmaceutical preparations quantitation SARS-CoV-2 sensitivity Severe acute respiratory syndrome synchronous synchronous fluorimetry. Treatment United State United States United States Food and Drug Administration viral infection were measured [DOI] 10.1002/bio.4240 PMC 바로가기 [Article Type] Article
Target-triggered cascade signal amplification for sensitive electrochemical detection of SARS-CoV-2 with clinical application임상 적용과 함께 SARS-CoV-2의 민감한 전기화학적 검출을 위한 표적 트리거 캐스케이드 신호 증폭Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis applied cascade Cascade signal amplification catalytic catalyzed clinical sample clinical samples complex coronavirus COVID-19 COVID-19 diagnosis Detection limit diagnosis of COVID-19 disease DNA early stage effective electrochemical biosensor electrostatic interaction generate Health high stability incorporation Interference linear Lower outbreak Pandemics Prevent random RNA Saliva SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus simple Spread target targets [DOI] 10.1016/j.aca.2022.339846 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants스트레인 워즈 2: 결합 상수, 엔탈피, 엔트로피, 깁스 에너지 및 SARS-CoV-2 변이체의 결합 속도Article Published on 2022-05-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha strain B.1.1.529 Beta Beta strain binding binding constant calculated changes in characterized competition COVID-19 pandemic Delta Delta strain explained Gamma Gamma strain greater Hu-1 strain Interference kinetic Mutant strains mutate mutated Mutation mutations omicron Omicron strain. phenomenon RNA viruses SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 virus shown Standard strain Strains suppression the SARS-CoV-2 virus thermodynamic virus wild type [DOI] 10.1016/j.virol.2022.03.008 PMC 바로가기 [Article Type] Article
False positive Herpes Simplex IgM serology in COVID-19 patients correlates with SARS-CoV-2 IgM/IgG seropositivityCOVID-19 환자의 위양성 단순 헤르페스 IgM 혈청 검사는 SARS-CoV-2 IgM/IgG 혈청 양성과 상관관계가 있습니다Article Published on 2022-05-012022-09-12 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adding Adsorption cause caused correlation COVID-19 COVID-19 patient COVID-19 patients diagnosed enzyme-linked immunosorbent False positive Herpe herpes simplex Herpes simplex IgM Heterologous IgM IgM/IgG immunoassay Immunoglobulin immunoglobulins inhibiting Interference Laboratory features molecular non-specific Patient Pneumonia Polyvinylpyrrolidone positive reactive SARS-CoV-2 serological serology Significant simplex tested Viral pneumonia [DOI] 10.1016/j.diagmicrobio.2022.115653 PMC 바로가기 [Article Type] Article
Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 증식에 대한 시험관내 항바이러스 효과 평가Article Published on 2022-04-272022-09-11 Journal: Marine Drugs [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Abalone abalone viscera addition Antiviral antiviral activity Antiviral effect COVID-19 discus Effect evaluated expression level followed by Haliotis immunofluorescence assay inhibit SARS-CoV-2 inhibited inhibitory effect Interference nucleocapsid Nucleocapsid proteins plaque Plaque titration polysaccharide polysaccharides Propagation Quantitative Replication RNA copies RNA copy RT-PCR analysis Sargassum SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2 spikes seaweed seaweed. Treatment Vero E6 VERO E6 cells viral entry viral infection viscera western blot [DOI] 10.3390/md20050296 PMC 바로가기 [Article Type] Article
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B2R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Food for thought: Eating before saliva collection and interference with SARS‐CoV‐2 detectionResearch Article Published on 2022-02-232022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome children collected coronavirus detection determine diagnostic diagnostics dietary habit eating enzyme fasting food healthy children interfere Interference intrinsic MALDI‐TOF molecular noninvasive nucleic acid oral microbiota performed polymerase chain provided replicate required resolved RT‐PCR Saliva saliva specimens SARS‐CoV‐2 SARS‐CoV‐2 selected specimen unique upper respiratory infection variety viral nucleic acid virus Volume was reduced [DOI] 10.1002/jmv.27660 PMC 바로가기 [Article Type] Research Article
Viral Interference between Respiratory VirusesPerspective Published on 2022-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome airway epithelial cell animal model antagonistic cellular circulation coronavirus coronavirus disease COVID-19 demonstrated ENhance evaluated expected Host human metapneumovirus Human rhinovirus Immunity in viral infect Infection Influenza virus Innate immunity Interaction interactions Interference interferon Intervention involved lifted mechanism Multiple nonspecific offer pandemic positive prevented reduce Replication respiratory respiratory infections respiratory syncytial virus respiratory tract respiratory virus respiratory viruses resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 susceptible synergistic the interferon viral interference virus viruses zoonoses [DOI] 10.3201/eid2802.211727 PMC 바로가기 [Article Type] Perspective