Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
Influenza A virus infection and pathology in nasal and periocular tissues after ocular inoculation in ferretsArticle Published on 2022-11-012023-06-24 Journal: Veterinary pathology [Category] 신종인플루엔자, [키워드] ferret Inflammation Influenza intranasal ocular viral tropism [DOI] 10.1177/03009858221109103
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant variant of concern Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 VaccineArticle Published on 2022-10-252022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] ACM acute respiratory syndrome adverse effect airway antibodies antibody antigen presenting cells artificial Beta Beta spike C57BL/6 cell membrane clinical symptom clinical trial component conditions coronavirus coronavirus disease COVID-19 CpG cross-neutralizing current delivery of cargo dendritic cells dose doses evaluate evaluated Formulation generate Generation Good hamster hamsters immune responses immunization immunogenic induce Infection initiated interval intranasal mice neutralize neutralizing antibody neutralizing responses New omicron Phase 1 polymersome Practice PROTECT reduction repeated Safety SARS-CoV-2 second serum IgG spike Spike protein Spike-based vaccine Support Toxicity upper respiratory tract Vaccine variants viral clearance Viral load virus weight loss wild type [DOI] 10.1021/acsnano.2c06350 PMC 바로가기
Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteinsArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition Administered caused conserved coronavirus COVID-19 COVID-19 pandemic disease Efficacy effort expressing Hamster model highlighting intranasal intranasal vaccination memory morbidity and mortality nucleocapsid nucleocapsid protein pandemic PROTECT protection Protective Protein reduce reduced resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 single dose the N protein the SARS-CoV-2 vaccination Vaccine variants of concern vesicular stomatitis virus Viral antigen viral shedding VoC with COVID-19 [DOI] 10.3389/fimmu.2022.1025500 PMC 바로가기
Respiratory Vaccination with Hemagglutinin Nanoliposomes Protects Mice from Homologous and Heterologous Strains of Influenza VirusArticle Published on 2022-10-122023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] immunization Influenza intranasal liposomes Subunit vaccine [DOI] 10.1128/jvi.01006-22 PMC 바로가기
Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategyArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Administered airway boost Booster vaccine CAF®01 cationic clearance effective elicit elicited European evaluated HexaPro highlight Horizon IgA response immune response intranasal intranasal vaccine lower airway Lung pathology mucosal mucosal immune Neutralizing antibodies onward transmission Parenteral PROTECT protection regimen Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Serum neutralizing antibody severe disease spike supported Transmission trimer union upper airway upper airways upper respiratory tract Vaccine virus virus transmission [DOI] 10.1016/j.ebiom.2022.104248 PMC 바로가기
Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기