Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathwaysNF-kB 및 JAK/STAT 신호 전달 경로와 관련된 COVID-19 염증 과정에 관여하는 microRNA의 예측 및 분석Review Published on 2021-11-012022-09-11 Journal: International immunopharmacology [Category] SARS, 유전자 메커니즘, [키워드] activated Acute inflammation Analysis approved Cityscape connection contribute COVID-19 COVID-19 complications COVID-19 disease COVID-19 patient Critical Diseases Evidence exacerbate feature Host Inflammation Inflammatory inflammatory gene inflammatory genes inflammatory pathway inflammatory pathways inflammatory process Inflammatory response Inflammatory responses Interaction involved JAK-STAT signaling pathway JAK/STAT JAK/STAT signaling pathway manifestation microRNA miR-214 miR-223 miR-9 miRNA miRNAs mitigate morbidity and mortality NF-kB non-coding RNA Non-coding RNAs pandemic pathophysiological mechanism pathway Perturbation perturbations prediction Previous studies previous study Regulation STAT target target gene Target genes therapeutic target therapeutic targets virus [DOI] 10.1016/j.intimp.2021.108071 PMC 바로가기 [Article Type] Review
Tofacitinib in the treatment of skin and musculoskeletal involvement in patients with systemic sclerosis, evaluated by ultrasoundarticle Published on 2021-07-272024-09-02 Journal: Rheumatology International [Category] 대상포진, [키워드] JAK/STAT Systemic sclerosis Tofacitinib Ultrasound [DOI] 10.1007/s00296-021-04956-7 PMC 바로가기 [Article Type] article
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity선천 면역 자극을 통한 시험관 내 SARS-CoV-2 복제에 대한 인플루엔자 A 바이러스 결함 간섭 입자의 항바이러스 활성Communication Published on 2021-07-112022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] abrogation activity acute respiratory syndrome acute respiratory syndrome coronavirus Administered Antiviral antiviral activity antiviral agent Antiviral treatment applicability approved Cell Cell culture Co-infection Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defective interfering particles dependent on DI244 DIP disease effective Efficacy experiment human lung cells IAV Immune escape in vitro Influenza influenza A influenza A virus inhibitory effect Innate Innate immunity interferon JAK/STAT janus Janus kinase leads OP7 pandemic Particle Replication respiratory Respiratory virus infections SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT Stimulation Transcription Treatment treatment of COVID-19 Vaccine vaccine availability variant variants of SARS-CoV-2 virus virus infections [DOI] 10.3390/cells10071756 PMC 바로가기 [Article Type] Communication
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular MechanismsReview Published on 2021-06-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activate activated Activation alveolar appear approved attenuate autophagy canonical Cell cell type cellular cellular proliferation change characterized clinical trial compassionate use Cytokines described disorders distribution Endoplasmic reticulum epithelial Evidence excessive inflammation expression FGF fibroblast fibrosis growth factor idiopathic pulmonary fibrosis (IPF) IL-11 IL-13 IL-6 ILD in vitro in vivo model indicate inhibit Interaction interstitial inflammation interstitial lung disease (ILD) isoform isoforms JAK inhibitor JAK/STAT JAK/STAT pathway JAK2/STAT3 Janus kinases (JAK) lung Lung disease lung disorder Lung fibrosis lung tissue molecular monoclonal antibody over-expressed pathway Pathways PDGF Phosphorylation predominant proliferation pulmonary fibrosis recent role SARS-CoV-2 virus signal transducer and activator of transcription (STAT) small molecule Stress TGF-β1 [DOI] 10.3390/ijms22126211 PMC 바로가기 [Article Type] Review
JAK-STAT Pathway Inhibition and their Implications in COVID-19 TherapyJAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향Review Published on 2021-06-012022-09-11 Journal: Postgraduate medicine [Category] 유전자 메커니즘, 치료법, [키워드] 3CL pro activated Activation adverse effects B cell Baricitinib clinical trial contrary COVID-19 COVID-19 patients COVID-19 therapy cytokine cytokine receptor cytokine signaling Cytokine storm dendritic cell dendritic cells determine Disease progression disease severity Efficacy effort endothelial cells envelope protein envelope proteins excessive inflammation Host hosts immune response immune responses implicated incidence of COVID-19 increase Inflammation Inflammatory marker inflammatory markers Inflammatory mediators inhibition inhibitor inhibitors Jak Jak-STAT JAK/STAT JAK/STAT pathway JAK/STAT signaling janus Janus kinase Lymphocytes macrophages mechanism membrane molecular Monocytes natural killer cell Natural killer cells nucleocapsid nucleus Phosphorylation Pneumocytes progression promote protease Proteases Protein recruitment reduce Regulatory Authorities regulatory authority required ruxolitinib SARS-CoV-2 SARS-COV-2 infection severity signaling cascade signaling cascades STAT STATs structural protein structural proteins supported suppressor suppressors survival T cell the disease Therapeutic strategies therapeutic strategy Tofacitinib translate Trigger tyrosine [DOI] 10.1080/00325481.2020.1855921 PMC 바로가기 [Article Type] Review
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy과립구 대식세포 집락 자극 인자가 도래했다: 백신 보조제에서 항바이러스 면역요법까지Review Published on 2021-06-012022-09-11 Journal: Cytokine & growth factor reviews [Category] SARS, 치료제, [키워드] activate activated activated T cells adjuvant alveolar alveolar macrophage Antiviral antiviral action attribute cascades clinical trial COVID-19 Cytokines defend GM-CSF growth factor help IFN IFNs Immune cell immune cells immune response Immunotherapy infections Inflammation Innate immunity JAK/STAT knowledge Lungs Macrophage macrophage differentiation macrophages MAPK NFκB pathway Pathways PI3K pro-inflammatory cytokine pro-inflammatory cytokines produced Protein reduce respiratory infection respiratory infections STAT T cells Vaccine virus [DOI] 10.1016/j.cytogfr.2021.01.001 PMC 바로가기 [Article Type] Review
Network theoretic analysis of JAK/STAT pathway and extrapolation to drugs and viruses including COVID-19Article Published on 2021-01-282022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] algebraic Analysis Baricitinib Cellular signalling networks Clinical efficacy combinations coronavirus Coronavirus infection correlation COVID-19 Data mining databases drug drugs Effect evade explain Good immunology immunosuppressive agent JAK/STAT JAK/STAT pathway Japanese KEGG Kyoto mathematical measles methotrexate network Nipah virus phenotype Prednisolone R 2 reduction in respiratory syncytial virus rheumatoid arthritis rheumatology tested Tocilizumab Tofacitinib Treatment viral infection viral infections viral system virus West Nile Virus yellow [DOI] 10.1038/s41598-021-82139-x PMC 바로가기 [Article Type] Article
Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19Pharmacology Published on 2021-01-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] absence adjuvant alleviate Antiviral antiviral agent approach ARDS can be used caused chemokine chemokines Combination compounds Consequences COVID-19 COVID-19 pandemic CXCL8 cytokine Cytokine storm disease drug effective G-CSF GM-CSF Health HGF IL-10 IL-12 IL-13 IL-17 IL-1β IL-2 IL-4 IL-6 IL-7 IL-9 immune response Immunomodulatory agents Immunopathogenesis Immunosuppressant individual Infection inhibit inhibitory effect involved IP10 JAK/STAT Luteolin MCP1 morbidity and mortality natural NF-κB pathway Patient piperine plant-derived immunosuppressants Prevent pro-inflammatory cytokine resveratrol SARS-COV-2 infection Sepsis serious complication storm subsequent synergistic target targeting the cytokine storm the SARS-CoV-2 TNFα treat treating COVID-19 Treatment Vaccine while [DOI] 10.3389/fphar.2020.583777 PMC 바로가기 [Article Type] Pharmacology
Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinibarticle Published on 2020-11-302024-09-01 Journal: International journal of infectious diseases : IJID : official publication [Category] 말라리아, [키워드] Hemophagocytosis HLH JAK/STAT JAK1/2 inhibition Malaria tropica [Article Type] article
JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and RegenerationReview Published on 2020-11-262024-09-02 Journal: International Journal of Molecular Sciences [Category] 대상포진, [키워드] bone development homeostasis JAK/STAT Osteoblast osteoclast Osteoporosis [DOI] 10.3390/ijms21239004 PMC 바로가기 [Article Type] Review