Phytochemical Analysis, Antimutagenic and Antiviral Activity of Moringa oleifera L. Leaf Infusion: In Vitro and In Silico StudiesMoringa oleifera L. 잎 주입의 식물화학적 분석, 항돌연변이 및 항바이러스 활성: 시험관 내 및 실리코 연구Article Published on 2022-06-222022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activity Analysis analyzed anti-DNA damage antioxidant Antiviral AutoDock binding energy butylated hydroxytoluene carried chromone Compound COVID-19 Deoxyribonucleic acid determine DIPHENYL DNA DPPH Factor FIVE flavonoid flavonoids free radical gallic acid glucoside IC50 in silico in vitro information infusion inhibit Interaction involved kaempferol kelor. LC-MS leaf Liquid chromatography maintain Malnutrition mass spectrometry molecular docking Moringa Moringa oleifera MPro overcome phytochemical Plasmid positive controls Prevent protease PROTECT quercetin SARS-CoV-2 SARS-CoV-2 main protease silico studies silico study the SARS-CoV-2 treated was measured water [DOI] 10.3390/molecules27134017 PMC 바로가기 [Article Type] Article
Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS methodFavipiravir(SARS-CoV-2) 분해 불순물: LC/LC-MS 방법을 사용하여 완성된 고체 제형의 분해 메커니즘 식별 및 경로Article Published on 2022-06-012022-09-11 Journal: Biomedical chromatography : BMC [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile Analysis analyte approved buffer column temperature Compound concentrations condition country Degradation degradation impurities, favipiravir, LC/LC-MS, related substances, SARS-CoV-2, stability indicating. dosage Emergency use Favipiravir flow rate Forced harmonization HPLC identification injection International Conference LC-MS limit linear linearity mechanism Mobile molecular pathway performed physical Precision Quality control quantification reaction recovery study Research research and development robust SARS-CoV-2 SARS-CoV-2 patients separation stability Standard deviation stationary stationary phase stress conditions supported tablets temperature treat Volume water [DOI] 10.1002/bmc.5363 PMC 바로가기 [Article Type] Article
Plasma Metabolomic Alterations Induced by COVID-19 Vaccination Reveal Putative Biomarkers Reflecting the Immune ResponseCOVID-19 백신 접종으로 유도된 혈장 대사체 변화, 면역 반응을 반영하는 추정 바이오마커 공개Article Published on 2022-04-062022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] affecting alteration Amino acid amino acid metabolism amino acids analysed baseline Biomarker blood plasma ceramide Ceramides collected COVID-19 COVID-19 pandemic COVID-19 vaccination defined effective first dose heterogeneity highlighting immune cell responses immune response immune system individuals induced Inflammation LC-MS marker mass spectrometry metabolism metabolomics Mitigation molecular mRNA vaccination mRNA vaccine mRNA vaccines NAb NAbs Neutralizing antibodies neutralizing antibodies (NAbs). neutralizing antibody NMR nuclear nuclear magnetic resonance plasma Predictive profile Reflecting responders response response to vaccination SARS-CoV-2 spike proteins second dose second vaccination severity Spike proteins Trigger two groups vaccination were used [DOI] 10.3390/cells11071241 PMC 바로가기 [Article Type] Article
Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunityArticle Published on 2022-01-012022-11-15 Journal: Gut Microbes [Category] SARS, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody Antibody titer Bacteria binding collected commensal gut bacteria correlated COVID-19 vaccine cross-react cross-reactive cross-reactive antibody demonstrated DNA vaccine domain dominant dose E. coli Efficacy epitope fecal Gut gut bacteria gut microbiota healthy Host Hsp60 Hsp70 Immunity immunized Impact inactivated LC-MS metagenomic sequencing mice microbial monoclonal antibodies monoclonal antibody mounted naïve P144 Protein RBD binding reactive S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 vaccination SPF Spike protein Vaccine vaccine immunogenicity variety [DOI] 10.1080/19490976.2022.2117503 PMC 바로가기
Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis정량적 펩타이드 농축 LC-MS 분석을 사용한 신속하고 민감한 SARS-CoV-2 감염 검출Research Article Published on 2021-11-082022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analytical method approach asymptomatic individual Asymptomatic individuals Chain Reaction clinical sample clinical samples collected complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold detect diagnostics Human LC-MS limit of detection Liquid chromatography mass spectrometer mass spectrometry media molecular pandemic PBS peptide phosphate phosphate-buffered saline polymerase chain polymerase chain reaction positive proteomics Quantitative Rapid respiratory robust RT-PCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection sensitivity severe acute respiratory syndrome Coronavirus SISCAPA specificity Swab turnaround time Viral protein Viral proteins virus detection [DOI] 10.7554/eLife.70843 PMC 바로가기 [Article Type] Research Article
Resourcing, annotating, and analysing synthetic peptides of SARS-CoV-2 for immunopeptidomics and other immunological studies면역펩티도믹스 및 기타 면역학적 연구를 위한 SARS-CoV-2 합성 펩티드 자원화, 주석 달기 및 분석Article Published on 2021-09-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, [키워드] annotation Antigen applied binding affinities caused COVID19 database dataset document Epitopes examined facilitate generate human leukocyte antigen immune immune response immune responses immunological information LC-MS leukocyte library mass spectrometry modifications MS spectra pandemic peptide peptides predicted proteome proteomic provided SARS-CoV-2 SARS-CoV-2 proteome synthetic peptide synthetic peptides T cell T cell epitope T cell epitopes Tandem mass spectrometry target targets the SARS-CoV-2 vaccination [DOI] 10.1002/pmic.202100036 PMC 바로가기 [Article Type] Article
A rapid and reliable liquid chromatography/mass spectrometry method for SARS-CoV-2 analysis from gargle solutions and saliva양수 용액 및 타액에서 SARS-COV-2 분석을위한 신속하고 신뢰할 수있는 액체 크로마토 그래피/질량 분석법Research Paper Published on 2021-08-242022-09-01 Journal: Analytical and bioanalytical chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abstract Analysis approach Chain Reaction compatibility complementary diagnostic gargle solutions LC-MS Liquid chromatography mass spectrometry Multiple-reaction monitoring piloting polymerase chain polymerase chain reaction promote protocol quantitation Quantitative reproducibility reverse transcriptase RT-qPCR Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleoprotein sensitivity supplementary material Tandem mass spectrometry transcriptase Triple quadrupole [DOI] 10.1007/s00216-021-03614-y PMC 바로가기 [Article Type] Research Paper
Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time FingerprintingArticle Published on 2021-08-032022-10-31 Journal: Communications Biology [Category] COVID-19, [키워드] Analysis can be used Chalk Combination database Efficiency glycan glycobiology Greenland HPLC identification identify knowledge Laboratory LC-MS less mapping mass spectrometry MS3 peptide Protein protein digest quantitation resolved resolving power SARS-CoV-2 spike Structure time while [DOI] 10.1038/s42003-021-02455-w PMC 바로가기 [Article Type] Article
MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19Research article Published on 2021-08-012022-10-05 Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab [Category] 바이오마커, 변종, 진단, [키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization [DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article
Development and validation of a sensitive, fast and simple LC-MS / MS method for the quantitation of favipiravir in human serum인간 혈청에서 favipiravir의 정량을 위한 민감하고 빠르고 간단한 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-06-302022-09-11 Journal: Journal of chromatography. B, Analytical technolog [Category] 치료제, [키워드] applicability applied biological samples clinical trial Concentration coronavirus disease Coronavirus disease 2019 correlation coefficient COVID-19 COVID-19 patient develop development drug level electrospray ionization extraction Favipiravir Formic acid human serum inhibitor LC-MS less linear mass spectrometry methanol patients with COVID-19 performed Phenomenex pilot study plasma samples polymerase positive protein precipitation quantitation receiving reported robust simple tandem Tandem mass spectrometry Treatment validation validation study Viral RNA was performed was used water [DOI] 10.1016/j.jchromb.2021.122768 PMC 바로가기 [Article Type] Article