low expression – Page 2 – Communicable Diseases Research

Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA

SARS-CoV-2 RNA에 대해 재검사를 받은 환자의 전사 특성 및 면역 기능 장애

Article

Published on 2021-10-232022-09-10
Journal: Journal of Molecular Cell Biology [Category] Coronavirus, SARS, 바이오마커, 유전자 메커니즘,

MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals

고도로 노출된 개인의 무증상 SARS-CoV-2 감염 대 무증상 SARS-CoV-2 감염과 관련된 MHC 변이

Immunology

Published on 2021-09-282022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele analyzed antigen-presentation association Asymptomatic Combination comparable contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic activity develop downregulating DRB1 DRB1*04:01 Epigenetic explained expression Factor Factors followed by Genetic genetic factors Genotype genotypes Haplotype haplotypes histocompatibility complex HLA HLA-A HLA-DRB1 identify immune modulation immune response immunological individual individuals infected individual infected individuals Infection involved low expression major histocompatibility complex MHC MICA MICB modulate natural killer NK cell one individual partner pathway Quantitative remained residue resistance respiratory SARS-CoV-2 seronegative serum severe acute respiratory syndrome Coronavirus susceptibility Symptom symptomatic symptomatic COVID-19 symptomatic infection symptomatic infections uninfected variant variants whole-exome sequencing women
[DOI] 10.3389/fimmu.2021.742881 PMC 바로가기 [Article Type] Immunology

Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues

Article

Published on 2021-09-272022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 addition antibodies binding antibody auxiliary Cell Certain disease ciliary clinical evidence determine Epitopes examined expression Factor immunohistochemistry immunoreactivity increase in infect Infection infection with SARS-CoV-2 Inflammation investigated iris stroma lid low expression lung tissue margin Molecular medicine ocular performed positive positive controls Potential protein expression reported Retina reveal risk RNA RNA expression RNA sequencing RPE S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 receptor specimen staining supported tissue tissue sample tissues TMPRSS2 TMPRSS2 expression viral entry viral S protein was used were used while
[DOI] 10.1038/s41598-021-98709-y PMC 바로가기 [Article Type] Article

Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2

Research Paper

Published on 2021-09-032022-10-29
Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS,

[키워드] ACE ACE2 affecting AGT AGTR1 AGTR2 alteration analyzed binding biological processe Cancer cancer type cancers Cell cell lines classical clinical phenotype Comprehensive conducted correlated COVID-19 pandemic demographic determine differentially expressed distribution DNA methylation downstream expression expression pattern fibroblast Frequency Genomic alterations highest Host immune immune infiltration independent Injury kidney low expression macrophages MAS1 mechanism Modification modify ovarian Pan-cancer positively correlated posttranslational modification Prognostic factor Prognostic value promoter RAS RAS family Regulation renal renin-angiotensin system SARS-CoV-2 survival tissue tissues Tumor tumor microenvironment tumors
[DOI] 10.7150/ijbs.53312 PMC 바로가기 [Article Type] Research Paper

β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approach

Article

Published on 2021-08-302022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

[키워드] β-carboline ADP-ribose ADP-ribosylation analogue anti-SARS-CoV-2 approach binding affinity binding free energy bioinformatics candidate computational approach coronavirus creating database demonstrated docking docking score drug design Glide GS-441524 Host immune response implicated indicated induce Infection Ligand ligands low expression macrodomain macromolecule metabolite modulated Molecular dynamics simulation Nsp3 nsp3 macrodomain parameter Pathogenesis plasticity predicted receptor Remdesivir reported SARS-CoV-2 screened selected small molecule stability the SARS-CoV-2 Toxicity viral replication
[DOI] 10.3906/biy-2106-64 PMC 바로가기 [Article Type] Article

Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns

자궁 내 SARS-CoV-2의 수직 전파 평가: 9명의 임산부와 신생아

Article

Published on 2021-08-012022-09-11
Journal: Placenta [Category] SARS, 치료기술, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Amniotic fluid anal swab angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 baby Basigin blood vessel breastmilk Case report caused CD147 cell membrane Chain Reaction chaperone chorionic close contact Cohort studies collected consequence coronavirus COVID-19 cytoplasm debate delivery room diagnosed with COVID-19 distress droplet droplets during pregnancy enzyme epilepsy example expressed expression fetal fetal distress fetus GRP78 immunohistochemistry infect infected with SARS-CoV-2 interstitial low expression molecular mother Neonatal Newborn nucleoprotein Operating room pandemic performed Placenta Placenta infection placental placental abruption placental barrier placental tissue Pregnancy pregnant women Probability Protein qualitative detection receptor receptor protein RT-PCR SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein structural protein Symptom Targeted receptor protein expression tested transmission of SARS-CoV-2 transmitted verification vertical transmission virus
[DOI] 10.1016/j.placenta.2021.06.007 PMC 바로가기 [Article Type] Article

Is There any Alternative Receptor for SARS-CoV-2?

Letter to The Editor

Published on 2021-07-262022-10-31
Journal: Cell Journal (Yakhteh) [Category] COVID-19,

Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

Research

Published on 2021-07-152022-10-05
Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 바이오마커, 치료제,

[키워드] ACE2 activated acute inflammatory response acute lung inflammation acute respiratory distress acute respiratory syndrome Administered administration AGT alleviate alteration antiviral activity Antiviral effect Cell controls coronavirus COVID-19 patient damaged EC50 entry of SARS-CoV-2 expressed expression HEK-293T cell in vitro in vivo induce infected with SARS-CoV-2 Infection inflammatory cell infiltration Inflammatory cytokines inhibit inhibited intravenous investigated low expression lung inflammatory response lung tissue mechanism mice Mortality mRNA level NF-κB Potential treatment progression respiratory inflammation Salvia miltiorrhiza SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S syndrome target cells Therapeutics TLR4 treated Treatment VERO-E6 virus virus assay VSV-G
[DOI] 10.1038/s41401-021-00714-4 [Article Type] Research

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

Research

Published on 2021-07-082022-10-05
Journal: Nature cell biology [Category] SARS, 변종, 치료제,

Low Innate Immunity and Lagged Adaptive Immune Response in the Re-Tested Viral RNA Positivity of a COVID-19 Patient

COVID-19 환자의 재검사된 바이러스 RNA 양성에서 낮은 선천성 면역 및 지연된 적응 면역 반응

Immunology

Published on 2021-07-012022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] accompanied Adaptive immune response analyzed anti-RBD anti-RBD IgA anti-SARS-CoV-2 antibody anti-Spike IgG antibody Antigen Antigen presentation B cell CD8+ Cell Characteristics chemokine chemokines Chest computed tomography Computed tomography contributed COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines delayed anti-RBD/anti-spike IgA conversion delayed antigen presentation delayed neutralizing antibody response described disappearance discharged domain expression Gene Expression IgA IgG immune mechanism Innate interferon low expression lung lesion lung lesions Mild-to-moderate moderate moderate symptoms NAb NAbs Neutralizing antibodies neutralizing antibody observation observations Patient plasma positive RBD RBD IgA re-tested positivity recent reported response RNA SARS-CoV-2 SARS-CoV-2 RNA Seroconversion severe patients significantly Symptom Symptoms T cells T cells- the SARS-CoV-2 titer Viral Viral RNA Whole blood
[DOI] 10.3389/fimmu.2021.664619 PMC 바로가기 [Article Type] Immunology