Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizerCOVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus [DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article
Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity대사 모델링을 활용하여 COVID-19 질병 중증도와 관련된 기능적 대사 변경 식별Article Published on 2022-07-112022-09-11 Journal: Metabolomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute disease alteration approach claimed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic COVID-19 sample COVID-19 samples disease Disease progression disease severity driver dysfunction functional Genome Genome-scale metabolic modeling healthcare highlight histidine hospital Hospitalization Host identify immunopathology Increased Infection Inflammation Inflammatory Inflammatory response innate immune response innate immune system Invasion investigated ketone lung damage machine machine learning marker mechanism metabolic pathway metabolism metabolite metabolomics metabolomics. muscular Musculoskeletal offer pathway Pathway enrichment analysis patients plasma metabolome positive Predictive Prevalence Prevent reduce SARS-CoV2 SARS-CoV2 infection severe COVID-19 Severe infection Tryptophan University of Virginia viral replication Virginia weakness with COVID-19 [DOI] 10.1007/s11306-022-01904-9 PMC 바로가기 [Article Type] Article
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
Mast cells in lung damage of COVID-19 autopsies: A descriptive studyCOVID-19 부검의 폐 손상에서 비만 세포: 기술 연구Article Published on 2022-07-012022-09-12 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 lung damage mast cell [DOI] 10.1111/all.15293 PMC 바로가기 [Article Type] Article
Pulmonary Parenchymal Changes in COVID-19 SurvivorsObservational Study Published on 2022-07-012022-10-05 Journal: The Annals of thoracic surgery [Category] 임상, [키워드] age airways Asymptomatic Autopsy blinded change Control control group COVID-19 COVID-19 diagnosis COVID-19 group COVID-19 infection COVID-19 pandemic determine Diffuse alveolar damage Elective emphysema examined interstitial intra-alveolar lung lung cancer lung damage lung parenchyma lung resection macrophages median moderate multicenter observational study no difference nodule Organizing pneumonia pathologist Patient pulmonary pulmonary damage question specimen survivor Survivors survivorship vasculature was performed [DOI] 10.1016/j.athoracsur.2021.06.076 PMC 바로가기 [Article Type] Observational Study
Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 diseaseS1 소단위를 발현하는 뉴캐슬병 바이러스 벡터를 사용한 햄스터의 비강내 예방접종은 SARS-CoV-2 질병으로부터 동물을 보호합니다Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administer administration animals breath claimed coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical effective Efficacy elicited expressing hamster hamsters human clinical trial humoral immune responses immune responses long term lung damage mice Neutralizing antibodies newcastle disease virus pandemic phase prevented PROTECT Protective recent recorded recorded history reduced respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 disease severe acute respiratory syndrome Coronavirus short term significantly the disease the S1 subunit vaccination Vaccine vaccine candidate variant vectored vaccine Viral Viral load while [DOI] 10.1038/s41598-022-13560-z PMC 바로가기 [Article Type] Article
T-Cell Defects Associated to Lack of Spike-Specific Antibodies after BNT162b2 Full Immunization Followed by a Booster Dose in Patients with Common Variable Immune Deficiencies공통 가변 면역 결핍증 환자에서 BNT162b2 완전 면역 후 추가 용량 투여 후 스파이크 특이적 항체의 결핍과 관련된 T-세포 결함Article Published on 2022-06-142022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abnormality absence anti-SARS-CoV-2 IgG antibody Antibody Response Autoimmune Autoimmunity BNT162b2 booster booster dose CD40L CD8+ central memory circulating common Common variable immune deficiencies complex contributed COVID-19 CVID cytokine expression defect did not produce disease phenotype dose evaluated expressing expression followed by Frequency healthy donor IFNγ IgA IgA antibodies IgG immunization lung damage lymphocyte counts memory B memory B cells mRNA vaccine naïve of BNT162b2 Patient peptides Peripheral blood Responder SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibody specific antibody spike Spike protein T cell T-cell T-cells T-cells response Testing the patient TNFα Vaccine vaccine dose vaccine. variable virus spike protein was performed [DOI] 10.3390/cells11121918 PMC 바로가기 [Article Type] Article
Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?COVID-19 관리를 위한 Artemisia 추출물 및 Artemisinin 기반 항말라리아제: 이것이 COVID-19 치료에 효과적인 항바이러스제일 수 있습니까?Review Published on 2022-06-142022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active against acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Anti-inflammatory effects Antiviral Artemisia Artemisinin artemisinins combination therapies coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated derivative derivatives Drug repurposing drug repurposing. Effect Effectiveness Evidence exhibit Extract IL-6 Infection Inflammation inhibiting interleukin-6 Invasion lung damage malaria other diseases oxidative stress pandemic positive reducing Replication SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Symptoms the SARS-CoV-2 treat Treatment [DOI] 10.3390/molecules27123828 PMC 바로가기 [Article Type] Review
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19치명적인 COVID-19에서 연령 관련 위험 및 폐포 손상의 면역 및 상피 결정인자Article Published on 2022-06-082022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acute lung injury age aging alveolar alveolar injury Autopsy CD4+ CD8+ T cell Cell characterized contribute correlated COVID-19 cytotoxicity deficiency determinant Donor donors dysfunction early stage epithelial expressed fatal COVID-19 Gas exchange histopathological Immune cell increasing age individuals Infection lung lung damage Lung injury lymphocyte Macrophage Macrophage infiltration macrophages Older organ pathological stage performed pulmonary Pulmonary surfactants respiratory risk susceptibility T cell activation T cells T cells. underlie uninfected widespread [DOI] 10.1172/jci.insight.157608 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article