Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal modelsArticle Published on 2022-08-052022-10-06 Journal: Science (New York, N.y.) [Category] SARS, 조류인플루엔자, 진단, [키워드] acute respiratory syndrome animal model antibody Betacoronavirus conserved coronavirus demonstrated elicit elicited epitope Health immune response immunization immunodominant macaque mice mosaic neutralization PROTECT Randomly RBD RBDs response sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven spike receptor-binding domain Strains variant [DOI] 10.1126/science.abq0839 PMC 바로가기 [Article Type] Article
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage초기 단계에서 SARS-CoV-2에 감염된 Cynomolgus Macaque의 단백질체 및 대사체 특성 분석Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analyzed characterization COVID-19 COVID-19 infection cynomolgus macaque cynomolgus macaques Cytokines demonstrated dysregulated early infection early stage Efficacy effort feature Features immune immune response innate immune response lung tissue lung tissues lymphopenia macaque mechanism metabolomic profiling metabolomics moderate Moderate COVID-19 neutrophilia Pathogenesis pathogenic mechanism patients platelet activation proteomic proteomics SARS-CoV-2 SARS-COV-2 infection sera severe COVID-19 severe COVID-19 patients Stage Symptom the early stage. Therapeutics tissues Vaccine weakened [DOI] 10.3389/fimmu.2022.954121 PMC 바로가기 [Article Type] Article
Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaquesArticle Published on 2022-05-102022-10-05 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] AAV acute respiratory syndrome adeno-associated virus approval breakthrough infections consequence Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 vaccine cynomolgus macaque dose Durability Effective vaccines Efficacy elicit genetic vaccine greater Health Immunity IMPROVE injection lack low-dose macaque maintain mice Neutralizing antibody response non-human primate non-human primates other variant platform preventative vaccine PROTECT reduced Safe SARS-CoV-2 shown single dose the epidemic Vaccine vaccine antigen vaccine candidate variants variants of concern viral challenge virus [DOI] 10.1016/j.ymthe.2022.05.007 [Article Type] Article
Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primatesINO-4800 및 INO-4802를 사용한 프라임-부스트 백신 요법은 비인간 영장류에서 SARS-CoV-2에 대한 면역 반응을 증대 및 확대합니다.Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] Coronavirus, COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 Antibody Response Antibody responses blocking activity Booster vaccine booster vaccines characterized clinical evaluation COVID-19 DNA DNA vaccine Electroporation evaluated expansion homologous or heterologous immune evasion immune response Immunity immunogenicity INO-4800 Intradermal macaque natural infection Neutralizing pandemic portion question regimen regimens rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant SARS-CoV-2 variants shifting Strains Support T cell T cells These data Transmissibility vaccination Vaccine variant variants of concern wild-type SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.03.060 PMC 바로가기 [Article Type] Article
Vaccine protection against the SARS-CoV-2 Omicron variant in macaques원숭이의 SARS-CoV-2 오미크론 변종에 대한 백신 보호Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus antibody Antibody titer Antibody titers B.1.1.529 BNT162b2 BNT162b2 vaccine Bronchoalveolar lavage CD8+ T cell Cellular immune response contribute correlated cynomolgus macaques demonstrated Efficacy heterologous prime-boost High-dose homologous humoral immune responses macaque macaque. moderate mRNA mRNA-based mutated nasal swabs neutralizing antibody titers omicron populations question raised regimen respiratory response robust SARS-CoV-2 SARS-CoV-2 variant Spread T cell T cell responses the SARS-CoV-2 These data undetectable upper respiratory tract Vaccine Vaccines variant virus [DOI] 10.1016/j.cell.2022.03.024 PMC 바로가기 [Article Type] Article
A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant재조합 소단위 백신은 SARS-CoV-2 P.1(감마) 변이체에 대한 원숭이에서 강력하고 광범위하게 중화되며 내구성 있는 항체 반응을 유도합니다Article Published on 2022-04-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anamnestic response Antigen B.1.351 B.1.617 Beta boost breadth cause circulating Concentration coronavirus CoVaccine HT cynomolgus macaques delayed challenge disease dose dosed effective Efficacy elevated evaluated Final Gamma Heterologous IgG Immunity immunization immunized immunogenic induce Infection information isolates liquid Lower respiratory tract Lung pathology lyophilized macaque macaques moderate moderate to severe mRNA natural infection Neutralizing antibodies neutralizing antibody Neutralizing antibody response P.1 pandemic potent Prevent Protective protective immunity Protein recombinant reduce Reinfection required respiratory response restored robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease significantly specific neutralizing antibodies subunit subunit protein vaccine Subunit vaccine the SARS-CoV-2 upper and lower respiratory tract Vaccine vaccine immunity variants of concern Viral Viral load viral loads VoC VOCs [DOI] 10.1021/acsinfecdis.1c00600 PMC 바로가기 [Article Type] Article
A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques캡시드 바이러스 유사 입자 기반 SARS-CoV-2 백신은 높은 수준의 항체를 유도하고 붉은털 원숭이를 보호합니다Article Published on 2022-04-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody titers binding binding and neutralizing antibodies broad neutralizing antibodies capsid caused clinical testing comparable control group convalescent Corona coronavirus COVID-19 demonstrated disease dose-dependent manner Efficacy Evidence evidence of immunogenicity increase in Level macaque mice Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers no evidence of non-human primate non-human primates non-human primates (NHP) protection Protective reduction in respiratory rhesus macaques SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single vaccination Vaccine vaccine administration vaccine group variants variants of concern variants of concern (VOCs) Viral Viral load Virus-like particle virus-like particles virus-like particles (VLP). VLP VOCs worldwide pandemic [DOI] 10.3389/fimmu.2022.857440 PMC 바로가기 [Article Type] Article
Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primatesArticle Published on 2022-03-312022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome AS03 B.1.351 benefit Beta boost booster booster dose candidate clinical trials coronavirus cross-neutralization cross-neutralizing antibody cross-protection Delta demonstrated Effectiveness elicit evade FIVE functional antibody response Gamma implication increase Infection macaque mRNA naïve subjects neutralizing antibody Neutralizing antibody response non-human primate non-human primates offer omicron parental Preclinical research Protein vaccines question raise Receptor binding domain reduced responses robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly Spike protein subunit the SARS-CoV-2 the vaccine Vaccine vaccine candidates variant variants viral infection VoC VOCs [DOI] 10.1038/s41467-022-29219-2 PMC 바로가기 [Article Type] Article
Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants spike tomography vaccination Vaccine virus load [DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques히말라야 원숭이에서 SARS-CoV-2 감염 후 면역 및 질병 매개변수에 대한 에어로졸 전달 BCG 백신의 영향Immunology Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome adaptive aerosol Aerosol BCG vaccination antibody Antibody-mediated immunity antiviral immune response applied bacille Calmette-Guérin BAL BCG BCG vaccination Bronchoalveolar lavage cell-mediated immune response cellular challenge chemokine Classical CD14+ monocyte Classical CD14+ monocytes clearance collected comparable Concentration contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease severity cross-protection cross-protective cross-reactive cytokine disease disease pathology disease severity early disease ENhance exceeded groups Heterologous High dose Histopathology Humoral immunity hypothesised immune cells immune mechanism immune response immune responses immune signature Immunity immunological parameters indicated induce Infection influence initial innate immune innate immune cell Innate immune cells Innate immunity Intervention intrabronchial intranasal macaque macaques marker mechanism Monocytes nasal nasal and pharyngeal swabs natural infection non-specific Occurrence parameter pharyngeal populations primary site priming quantified reduce respiratory respiratory pathogen rhesus macaque rhesus macaques SARS-CoV-2 secretion severe acute respiratory syndrome Coronavirus subsequent susceptible swabs T-cell T-cells the disease tissue tissue sample titre titres trained immunity Tuberculosis tuberculosis vaccine Vaccine Viral Viral RNA virus [DOI] 10.3389/fimmu.2021.801799 PMC 바로가기 [Article Type] Immunology