Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants중증급성호흡기증후군 코로나바이러스 2 델타 및 오미크론 변이체에 대한 단일클론항체의 임상적 효능 및 시험관내 중화능Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Casirivimab casirivimab/imdevimab clinical Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient decrease delta variant dosage Efficacy except for exhibit Hospital stay Imdevimab in vitro in vitro data in vivo Infection mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization capacity neutralizing capacity neutralizing effect Omicron variant Patient patients treated performed provided receiving respiratory respiratory tract respiratory viral RNA SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus sotromivab Sotrovimab the SARS-CoV-2 therapeutic therapy treated variant Viral Virus neutralization virus neutralization assay. virus neutralization assays [DOI] 10.1002/jmv.27916 PMC 바로가기 [Article Type] Article
Reaction of SARS-CoV-2 antibodies with other pathogens, vaccines, and food antigensArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] antibodies antibody Antigen antigens autoantigen B cell Bacteria Bacterial BCG Blood casein Combination COVID-19 cross-protection cross-react cross-reactive antibody cross-reactivity DTaP elicit elicited experiment food antigens herpesviruses homology human tissues immune immune response immune system Immunity investigated memory T molecular molecular mimicry monoclonal monoclonal antibody pathogen Pathogens peptide polyclonal antibody Proteins reaction reactivity SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 spike protein shown similarity the SARS-CoV-2 virus Vaccine vaccine antigen Vaccines Vaccines. Viral antigen viruses [DOI] 10.3389/fimmu.2022.1003094 PMC 바로가기
Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron VariantArticle Published on 2022-09-212022-11-15 Journal: Clinical microbiology reviews [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome advance antibodies antibody-based therapies booster characterized Community coronavirus counter COVID-19 disease severity driving effective strategy Effectiveness entry inhibitors Entry mechanism enzyme evade faster fusion inhibitors fusion pathway highlighting immune Immune escape immune evasion Immunity immunotherapies Infection inhibitor inhibitors Innate mitigate monoclonal motif mutated natural infection omicron pan-CoV vaccines Perspective raising resistance. resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 variant SARS-CoV-2 viral Spread T cell T cell response the SARS-CoV-2 the spike protein Transmissibility Transmission Vaccine vaccine-induced antibody Vaccines variant variants virus [DOI] 10.1128/cmr.00014-22 PMC 바로가기
Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cellsArticle Published on 2022-09-162022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] ACE2-positive cell addition ADE ADE activity adverse effect anti-SARS-CoV-2 antibody Antibody-dependent enhancement Antisera approved caused collected concentrations COVID-19 pandemic examined exhibited FcR in vivo individual Infection inoculated mAb mAbs monoclonal mRNA vaccines Neutralizing Neutralizing activity omicron S-protein SARS-CoV-2 spike protein sera therapeutic therapeutic effect [DOI] 10.1038/s41598-022-19993-w PMC 바로가기
Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2Article Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 expression Affect antibodies antibody Cell cell receptor domain Effectiveness expression Infection lentivirus Level monoclonal monoclonal antibody N-terminal domain neutralization Neutralization assay neutralize Neutralizing activity neutralizing antibody neutralizing antibody epitopes NTD polyclonal antibody polyclonal human sera pseudovirus Pseudovirus neutralization assays RBD Region SARS-CoV-2 Serum Neutralization spike epitope subset target target cell target cell receptor expression. target cells the RBD therapeutic [DOI] 10.3390/v14092061 PMC 바로가기
A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorArticle Published on 2022-09-132022-11-15 Journal: Cell Reports [Category] SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies antibody antibody repertoire Bioactivity characterized contribute CP: Immunology deep sequencing developmental Donor early infection elicit event facilitate immunogen information Lineage longitudinal maturation monoclonal NAb neutralizing antibody neutralizing antibody. P2C-1F11 lineage pathway reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody sequence significantly viral infection [DOI] 10.1016/j.celrep.2022.111335 PMC 바로가기
Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral responseArticle Published on 2022-09-062022-11-15 Journal: Oncoimmunology [Category] SARS, 변종, 진단, [키워드] analyzed approach booster booster dose CD4 CD8 cellular response diagnosed disease Effectiveness FIVE Heterologous humoral IFN-γ immunization MMD MMR monoclonal monoclonal gammopathies mRNA mRNA vaccination Multiple Multiple myeloma Neutralizing Neutralizing antibodies Neutralizing antibody titer Neutralizing titer omicron Patient patients reduced retained SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination significant increase spike variants spike variants. Spike-specific antibody T cell Undetermined vaccination vaccine-induced antibody variant variants [DOI] 10.1080/2162402X.2022.2120275 PMC 바로가기
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigensArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibody Antigen assist Betacoronavirus betacoronaviruses bioinformatic analysis convalescent coronavirus cross-reactive cross-reactive antibodies cross-reactive antibody diagnostics Donor donors Effectiveness fatality functional individual mapped mapping monoclonal natural human antibody neutralization potency Next-generation sequencing NGS non-specific Patient performed produced response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specificity tested the antibody Transmissibility unique Vaccines yeast yeast display. [DOI] 10.3389/fimmu.2022.977064 PMC 바로가기
Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmissionArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration antibody approved Booster vaccine Combination Community consequence current Delta delta variant diagnosed dominant dominant variant Efficacy Evolution FDA higher infectivity human lung tissue immune Immune escape immune evasion Immunity immunocompromised individual IMPROVE Infection less monoclonal monoclonal antibodies Mutation mutations neutralising omicron Omicron variant Omicron. other variant Protein public health recombination event reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variants severity Sotrovimab spike Spread syncytia formation the SARS-CoV-2 therapeutic use Transmission Vaccine variant variants of SARS-CoV-2 Wuhan-Hu-1 zoonotic [DOI] 10.1002/rmv.2381 PMC 바로가기
Epitope mapping of neutralising anti-SARS-CoV-2 monoclonal antibodies: Implications for immunotherapy and vaccine designArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome affected anti-SARS-CoV-2 coronavirus coronavirus disease COVID-19 COVID-19 infection death disease drug Emergency use epitope epitope mapping Epitope-based vaccine food Immunotherapy individuals Medicine monoclonal monoclonal antibody neutralising neutralising MAb neutralising monoclonal antibody. pandemic RBD reactivity reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus the SARS-CoV-2 virus Vaccine design virus [DOI] 10.1002/rmv.2347 PMC 바로가기