Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variantArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme coronavirus COVID-19 domain Effect ENhance human ACE2 human Angiotensin-converting enzyme humans infect investigated mouse angiotensin-converting enzyme 2 Mutation Mutational hotspots N501Y Omicron variant question raised RBD receptor Receptor-binding domain (RBD) SARS-CoV-2 Spread the RBD viral adaptation X-ray X-ray crystallography [DOI] 10.1073/pnas.2206509119 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States미국 조지아주 샘플에서 SARS-CoV-2 게놈의 돌연변이 역학 분석Article Published on 2022-10-202022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Amino acid Analysis caused China clade clades Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 country Course COVID-19 D614G determine disease England Europe Filter Genome genome sequence Genome sequences Host indicate limit majority Multiple Multiple studies mutated Mutation N501Y NCBI database Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide nucleotides online tool over P681H pandemic Phylogenetic Quality control reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sequence Sequence alignment sequenced genomes sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread state survival the United State the WHO translation Transmission variant variants virus was used Wuhan [DOI] 10.1016/j.gene.2022.146774 PMC 바로가기 [Article Type] Article
Arylcoumarin perturbs SARS-CoV-2 pathogenesis by targeting the S-protein/ACE2 interactionArticle Published on 2022-10-112022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adaptive Analysis antibody binding affinity binding site convalescent coumarin COVID-19 D614G death derivative develop docking drug human Angiotensin-converting enzyme human host in vitro in vivo Infection inhibitor inhibitors Interaction lack molecular molecular docking analysis Mutation N501Y new SARS-CoV-2 NF1 oxygen protein complex protocol rapid increase receptor Reinfection required S-protein SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein second wave Spike proteins Treatment vaccinated individuals vaccination variant variants viral genome [DOI] 10.1038/s41598-022-20759-7 PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challengeArticle Published on 2022-10-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] amino acid change antibody B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.1 B.1.617.2 Beta Combination D614G mutation Delta disease severity domain E484K evaluated expressing Gamma greater highlight human-to-human transmission induce L452R Lineage lineages mice moderate mouse-adapted SARS-CoV-2 mRNA vaccine Multiple multiple mutations Mutation mutations N439K N501Y neutralization neutralized Neutralizing activity neutralizing antibody observation omicron other variant P.1 P681R pandemic PROTECT Protein pseudotyped pseudovirus reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serum antibody T478K the S protein Transmissibility vaccination Vaccine variant variants virulent [DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse OocytesArticle Published on 2022-10-012022-11-16 Journal: Reproductive Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied assembly caused control group COVID-19 pandemic demonstrated female functions Health impairment indicated Infection influence maturation mouse mutant mutant spike protein N501Y N501Y variant Oocyte Oocyte maturation oocytes potential risk Protein provided reproductive SARS-CoV-2 SARS-CoV-2 spike protein significantly increased spike Spike protein Spindle spindle assembly the mean [DOI] 10.1007/s43032-021-00809-7 PMC 바로가기
Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS-CoV-2, MERS-CoV, Ebola, Zika, HIV-1, and influenza A virusSARS-CoV-2, MERS-CoV, 에볼라, 지카, HIV-1 및 인플루엔자 A 바이러스에 특히 중점을 두고 중요한 신흥 바이러스 병원체에 대응하는 강력한 생물 치료제로서의 형질전환 소 유래 광범위 중화 항체Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant adjuvants Alpha animals antibody antibody-based therapies Antiviral approach approved assist Beta Biotherapeutics blocked bovine bovine-derived biotherapeutics Clinical studies colostrum convalescent coronavirus creating Delta disease Donor E484K Ebola effective Efficiency emerging viruses Epsilon Gamma highlight HIV-1 Human Human immunodeficiency virus human immunodeficiency virus type 1 human infection human infections hyperimmunization immune immunoreactivity Immunotherapy Influenza influenza A influenza A virus Iota K417N L452R Lambda MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus mutations N501Y neutralization neutralized Neutralizing Neutralizing activity neutralizing antibody omicron Omicron variants outbreak P681R Pandemics platform polyclonal antibodies polyclonal antibody produced Protective respiratory respiratory syndrome coronavirus robust Safe SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown T478K therapeutic option transchromosomic bovines. Vaccine variant variants variants of concern variants of interest Viral viral infection viral infections viral pathogen VOCs VOIs Zika [DOI] 10.1002/jmv.27907 PMC 바로가기 [Article Type] Review
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기
Intrahost SARS-CoV-2 k-mer Identification Method (iSKIM) for Rapid Detection of Mutations of Concern Reveals Emergence of Global Mutation PatternsArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] bioinformatics can be used computational genomics concern COVID-19 dataset detect detection emergence Frequency genome assembly Genome sequencing genomic genomic sequencing identification identify increases in Intrahost variation L452R Lineage lineages Mutation N501Y pattern Rapid raw data SARS-CoV-2 Sequencing spike Spread Surveillance the timing variant variants variants of concern Variation [DOI] 10.3390/v14102128 PMC 바로가기