SARS-CoV-2 spike evolutionary behaviors; simulation of N501Y mutation outcomes in terms of immunogenicity and structural characteristicSARS-CoV-2 스파이크 진화 행동; 면역원성 및 구조적 특성 측면에서 N501Y 돌연변이 결과 시뮬레이션Article Published on 2022-02-012022-09-11 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach changed characteristic coding region coding regions computation Computational biology consequence coronavirus COVID-19 enzyme facilitate focus free energy Genome host cells immunogenicity immunoinformatics increase interact Lineage molecular molecular dynamics Mutation N501Y N501Y mutation Noncoding region occur outcome Protein protein folding protein-protein interaction RBD RBD mutations Receptor-binding domain reduce Region reported SARS-CoV-2 SARS-CoV-2 spike secondary structure severe acute respiratory syndrome Coronavirus significantly South Africa Spike protein Spike. stability tertiary structure the receptor-binding domain the spike protein virus without affecting [DOI] 10.1002/jcb.30181 PMC 바로가기 [Article Type] Article
Comparative Analysis of Five Multiplex RT-PCR Assays in the Screening of SARS-CoV-2 VariantsArticle Published on 2022-01-272022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Accuracy Beta Catcher circulating Comparative COVID-19 Delta diagnostic diagnostics Direct E484K evaluate examined Extended FIVE Gamma identify Iota Italy K417N L452R Laboratory Liguria mapped multiplex N501Y mutation Nasopharyngeal swab Next-generation sequencing NGS pandemic performed ranged reference genome RT-PCR RT-PCR assays RT-PCR test SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Screening sensitivity specific mutation specimen Surveillance the SARS-CoV-2 variant variants of concern wild-type strain [DOI] 10.3390/microorganisms10020306 PMC 바로가기 [Article Type] Article
Immunity evasion: consequence of the N501Y mutation of the SARS-CoV-2 spike glycoproteinShort Communications Published on 2022-01-142022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] N501Y mutation spike glycoprotein the SARS-CoV-2 [DOI] 10.1186/s43141-021-00287-z PMC 바로가기 [Article Type] Short Communications
A low-cost TaqMan minor groove binder probe-based one-step RT-qPCR assay for rapid identification of N501Y variants of SARS-CoV-2SARS-CoV-2의 N501Y 변이체를 신속하게 식별하기 위한 저비용 TaqMan 작은 홈 결합제 프로브 기반 1단계 RT-qPCR 분석Article Published on 2022-01-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 치료기술, [키워드] Accuracy allele frequency analytical sensitivity B.1.1.7 B.1.351 collected COVID-19 detect determine diagnostic Diagnostic accuracy evaluated expand Frequency Genome Genome sequencing gold gold standard health authorities house identify in some Lineage low frequency Mutation N501Y N501Y mutation N501Y variants One-step RT-qPCR positive Prevalence qPCR qPCR assay reduced reference standard respiratory specimen respiratory specimens robust RT-qPCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Surveillance TaqMan time-consuming Transmissibility variant Variant of concern. variants variants of concern variants of SARS-CoV-2 whole-genome sequencing widespread wildtype [DOI] 10.1016/j.jviromet.2021.114333 PMC 바로가기 [Article Type] Article
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicineSARS-CoV-2 계통 중 Omicron N501Y 돌연변이: 티로신 키나아제 및 가상의 용도 변경 의약품에 대한 강력한 결합의 인실리코 분석Article Published on 2022-01-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 신약개발, [키워드] Analysis analyzed applied B.1.1.7 B.1.351 binding Cancer Cancer patients Care EGFR elevated ENhance enrichment Factor host cell host cells hypothetical Interaction kinase kinases Lineage lineages management molecular docking analysis Mutation N501Y N501Y mutation network network pharmacology omicron pandemic pathogenic Pathways Phosphorylation PI3K polar Precision predicted Receptor binding domain SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 lineage SARS-CoV-2. Signaling Spike receptor binding domain therapy tyrosine variants [DOI] 10.1016/j.tmaid.2021.102242 PMC 바로가기 [Article Type] Article
Chimeric crRNA improves CRISPR–Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2Chimeric CrRNA는 SARS-COV-2의 알파, 베타, 감마 및 MU 변형의 N501Y 돌연변이 검출에서 CRISPR – CAS12A 특이성을 향상시킵니다.Research Article Published on 2021-12-232022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] Alpha Beta chimeric CRISPR Critical detect Gamma IMPROVE N501Y N501Y mutation nucleotide platform SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity specificity variants variants of SARS-CoV-2 [DOI] 10.1371/journal.pone.0261778 PMC 바로가기 [Article Type] Research Article
Clinical Characteristics of Patients with SARS-CoV-2 N501Y Variants in General Practitioner Clinic in JapanArticle Published on 2021-12-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval adjust age analyzed Celsius Characteristics clinic clinical Clinical characteristics clinical symptom Clinical symptoms COVID-19 COVID-19 patient demographics deviation Fever General practice groups Japan lung involvement Multivariate analysis Mutation N501Y N501Y mutation no significant difference Odds ratio Patient Pneumonia Practitioner Prevalence radiological radiological finding remained retrospective cohort study SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome coronavirus-2 significantly significantly higher Treatment wild-type [DOI] 10.3390/jcm10245865 PMC 바로가기 [Article Type] Article
Differential Interactions between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern인간 ACE2와 SARS-CoV-2 변이의 RBD 스파이크 간의 차등 상호작용 우려Comparative Study Published on 2021-12-142022-09-11 Journal: Journal of chemical theory and computation [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha angiotensin Beta binding interaction binding interactions causative agent center concern contagious Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta disease control drug entry of SARS-CoV-2 Epsilon experiment followed by force Gamma highest Human human Angiotensin-converting enzyme inhibit SARS-CoV-2 interact interactions investigated K417N L452R molecular molecular dynamics N501Y N501Y mutation pandemic performed prevention RBD RBD of SARS-CoV-2 receptor Receptor-binding domain reported SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SMD spike Spike protein the receptor-binding domain the spike protein the United State United States variant variants variants of concern variants of interest [DOI] 10.1021/acs.jctc.1c00965 PMC 바로가기 [Article Type] Comparative Study
Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater폐수에서 우려되는 변이체의 SARS-CoV-2 서명 돌연변이를 감지하는 물방울 디지털 RT-PCRArticle Published on 2021-12-102022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, [키워드] aligned allocation antibody B.1.1.7 B.1.351 can be used causative agent Community coronavirus COVID-19 demonstrated detect detection determine droplet E484K indicate information K417N L452R limit Lineage measure MONITOR monitoring Mutation mutation N501Y N501Y N501Y mutation Netherlands Occurrence proportion Public public health quantification RNA RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants sewage Sewage surveillance. shown Spread Support Surveillance Transmissibility Type vaccination variant variants variants of concern viral spread VoC wastewater [DOI] 10.1016/j.scitotenv.2021.149456 PMC 바로가기 [Article Type] Article
A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutationsE484K 및 N501Y 돌연변이를 포함하는 SARS-CoV-2 변이체를 선별하기 위한 새로운 진단 테스트Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] carried change collected concerning COVID patient Covid patients diagnostic dramatic increase E484K epidemiological frequencies Frequency geographical areas Hackensack Meridian Health network hospital Meridian molecular Molecular assay Mutation N501Y N501Y mutation Nasopharyngeal swab Neutralizing antibodies neutralizing antibody New Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Screening Sequencing spike Spike protein Transmissibility unmet need variant variants variants. Viral virus while [DOI] 10.1080/22221751.2021.1929504 PMC 바로가기 [Article Type] Article