Can the Nasal Cavity Help Tackle COVID-19?Review Published on 2021-10-032022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] administration alternative route applied approach approved Can Cavity COVID-19 COVID-19 pandemic information intranasal delivery medication nasal Nasal cavity nasal vaccine SARS-CoV-2 therapeutic strategy Vaccine [DOI] 10.3390/pharmaceutics13101612 PMC 바로가기 [Article Type] Review
Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association with Viral Load, Independent of Symptoms상부 호흡기에서 SARS-CoV-2에 대한 염증 반응의 종단 분석은 증상과 무관한 바이러스 부하와의 연관성을 보여줍니다Observational Study Published on 2021-09-282022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 임상, 진단, [키워드] Activation active site analyzed Anosmia antiviral response CCL2 collected conducted Control correlated COVID-19 cohort CXCL10 cytokine cytokine level cytokine levels cytokine response Cytokines different time point different time points dissemination elevated enrolled Geneva University Hospitals GM-CSF IgA IgG IL-6 immunological characteristics increase in Increases increases in independent of innate response intranasal load Local longitudinal Mild myeloid cells nasal Nasal cavity nasal epithelium Nasal wash observational study Patient produced recruitment remained respiratory response Result S1 domain Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum serum cytokine levels specimen Spike protein subset supplementary material Switzerland Symptom symptom onset Symptoms the spike protein therapeutic approaches tract understanding upper upper respiratory tract Viral load Virological virological and immunological characteristics virus [DOI] 10.1007/s10875-021-01134-z PMC 바로가기 [Article Type] Observational Study
Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokersArticle Published on 2021-09-282023-06-15 Journal: Cell Reports Medicine [Category] MERS, SARS, [키워드] ACE2 ciliated epithelial cell COVID-19 IFN-β1 Nasal cavity SARS-CoV-2 smoking TMPRSS2 Trachea upper airway [DOI] 10.1016/j.xcrm.2021.100421 PMC 바로가기 [Article Type] Article
Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamstersSARS-CoV-2 Alpha 변이체의 저용량 접종은 햄스터의 이전 변이체보다 더 효율적으로 전달합니다.Article Published on 2021-09-202022-09-10 Journal: Communications Biology [Category] SARS, 변종, [키워드] Alpha Alpha variant B.1.1.7 circulating D614G demonstrated dose effective exhibit experimental evidence explain hamster hamsters Human In-vitro Infection key factor lack Lineage low dose lower dose nasal Nasal cavity observé other variant other variants parental replicate SARS-CoV-2 short duration shown Spread strain Transmission Transmission model underlie variant variant of SARS-CoV-2 variants of SARS-CoV-2 Viral Viral transmission [DOI] 10.1038/s42003-021-02640-x PMC 바로가기 [Article Type] Article
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy생쥐에서 SARS-CoV-2 감염의 실시간 영상은 중화 항체가 최적의 효능을 위해 Fc 기능을 필요로 함을 보여줍니다Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Administered antibody applied bioluminescence imaging BLI Brain convalescent COVID-19 death Effect effective Efficacy Fab Fc effector functions Fc function function hACE2 highlight human ACE2 human ACE2 transgenic mice immune protection immunopathology in vivo indicated Infection Inflammatory response Inflammatory responses Interaction intranasally K18-hACE2 mice limit lung Lungs mechanism mice MONITOR Monocytes NAb NAbs nanoluciferase nasal Nasal cavity natural killer natural killer cell Natural killer cells neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils organ Pathogenesis prevented Prophylaxis required resolved reveal SARS-CoV-2 SARS-COV-2 infection subject systemically therapy transgenic treating COVID-19 Treatment virus spread [DOI] 10.1016/j.immuni.2021.08.015 PMC 바로가기 [Article Type] Article
Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose급성 SARS-CoV-2 감염은 코의 녹농균(Pseudomonas aeruginosa)을 비롯한 세균성 병원체의 풍부함 증가와 관련이 있습니다Article Published on 2021-08-312022-09-11 Journal: Cell Reports [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Bacterial infections bacterial pathogen Bacterial pathogens caused Coinfection conducted contribute coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 Diagnosis epithelia healthcare worker host response Host transcriptional response incidence Infection Inflammation Inflammatory response innate immune response Microbiome nasal Nasal cavity nasal microbiome neuronal observé Outpatient Pathogenesis Pathogens patients Pseudomona Pseudomonas aeruginosa RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-positive patient SARS-CoV-2-positive patients Secondary bacterial infections severe acute respiratory syndrome Coronavirus severely ill patients These data unique viral RNA load [DOI] 10.1016/j.celrep.2021.109637 PMC 바로가기 [Article Type] Article
Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series인간 중이 대 비강에서 SARS-CoV-2의 면역조직화학 및 qPCR 검출: 케이스 시리즈Case Reports Published on 2021-08-282022-09-10 Journal: Head and Neck Pathology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] ACE2 Adhesion Molecule angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Biomarker Cell cell adhesion molecule colonize control patients coronavirus COVID-19 COVID-19 patient detection disorder ear EpCAM epithelia epithelial epithelial cell epithelial cells evaluate Evidence expression hearing loss histologic Human immunohistochemistry implicated Infection middle Middle ear mucosa nasal Nasal cavity nasal epithelial cell Nasal Epithelial cells nasal tissue nasal tissue samples otitis otitis media pathophysiology Post-mortem qPCR Quantitative Quantitative RT-PCR receptor required RT-PCR SARS-CoV-2 SARS-CoV-2 entry sensorineural hearing loss Sery Spread Viral viral infections Viral load [DOI] 10.1007/s12105-021-01378-6 PMC 바로가기 [Article Type] Case Reports
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 MiceK18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과Article Published on 2021-08-202022-08-31 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제, [키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected [DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques붉은털 원숭이의 점막 백신에 의한 SARS-CoV-2 감염에 대한 보호Research Article Published on 2021-04-282022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료기술, [키워드] Adaptive immunity binding boost cellular immunity complementary controls COVID-19 demonstrated detectable dimeric Efficacy elicited IFN-α IgA IL-15 immunization Innate immunity intramuscularly intranasal Lower respiratory tract mucosal multiple dose multiple doses naive controls nasal Nasal cavity neutralizing antibody PROTECT protection Protective protective mechanism protective mechanisms respiratory response rhesus macaque rhesus macaques RNA robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Spike protein spike protein S1 Subunit vaccine subunit vaccines systemically T cell TLR agonists Vaccine Vaccines Viral viral replication virus [DOI] 10.1172/jci.insight.148494 PMC 바로가기 [Article Type] Research Article
Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells플루티카손 프로피오네이트는 1차 인간 비강 상피 세포에서 폴리(I:C) 유도 ACE2를 억제합니다Cellular and Infection Microbiology Published on 2021-04-262022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술, [키워드] ACE2 ACE2 expression ACE2 protein Activation Affect affected agonist analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry collected Corticosteroid COVID-19 dissemination enzyme epithelial cells evaluate examined expression expression of gene fluticasone fluticasone propionate Fold change followed by Gene Expression Health health problem HNECs host cells Human immunoblot immunofluorescence incubated Incubation individuals Infection initial innate immune interferon intranasal intranasal steroid spray investigated mRNA expression nasal Nasal cavity nasal epithelial cell nasal mucosa NFκB objective poly(I:C poly(I:C) promote propionate protease Protein quantitative PCR receptor regulated required reservoir Result SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral SARS-CoV2 Serine serine 2 significantly increased Spread steroid suppresse suppressed thought TLR TLR agonists TLR3 TMPRSS2 Toll-like receptors transmembrane transmembrane protease serine 2 Viral virus infection [DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology