PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3 + T cellsResearch Article Published on 2021-02-172022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Antiviral blood circulation catastrophic CD3 CD3+ T cells Contact DCs dendritic cell dissemination Effect epidemic diarrhea induce infect infected NEC Infection Infection of NEC Inflammatory cytokine intestinal intestinal mucosa intestine Invasion late stage nasal Nasal cavity nasal epithelial cell NECs Neonatal neonatal piglets PEDV replicate subepithelial T cell transfer virus [DOI] 10.1186/s13567-020-00883-w PMC 바로가기 [Article Type] Research Article
Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In VitroArticle Published on 2021-02-112022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Acidic acute respiratory syndrome affected Air-liquid interface anti-apoptotic Antiviral compounds antiviral drug berberine chemokines complement Concentration concentrations coronavirus COVID-19 cytokine early stage effective Efficacy Endosomes expression Human human pathogen increase in indicated Infection inhibited isolate late stage less nasal epithelial cell neutralize Obatoclax preventive measures primary target cells Protein reduced repressed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Vaccines viral life cycle viral RNA synthesis [DOI] 10.3390/v13020282 PMC 바로가기 [Article Type] Article
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19구아노신 뉴클레오티드 유사체의 이중 전구약물인 AT-527은 시험관 내 SARS-CoV-2의 강력한 억제제이자 COVID-19 치료를 위한 유망한 경구 항바이러스제입니다Antiviral Agents Published on 2021-02-082022-08-31 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered Antiviral approved AT-511 AT-527 AT-9010 causative agent cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective epithelial cells FDA Guanosine half-life HCoV HCoV-OC43 hepatitis C hepatitis C virus Huh-7 cells human airway epithelial human coronavirus human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide OC43 oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir Replication replication of SARS-CoV-2 required respiratory Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes Research Published on 2020-04-232022-10-05 Journal: Nature Medicine [Category] 유전자 메커니즘, [키워드] clearance clinical sample co-expressed Corneal COVID-19 patient Efficiency expressed expression healthy highlighting human donors initial innate immune gene Innate immunity inquiry intestinal epithelial cells investigated involved multiple tissue nasal epithelial cell offer resource SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 transmission Single-cell RNA-sequencing Spread transcript viral infection [DOI] 10.1038/s41591-020-0868-6 [Article Type] Research