Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread하이드 록시 프로필 메틸 셀룰로스 기반 비강 스프레이는 시험 관내 SARS-COV-2 감염을 효과적으로 억제하고 확산Communication Published on 2021-11-232022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antiviral property appear causative agent Cell Cell culture coronavirus coronavirus disease COVID-19 dose dose-dependent manner form Garlic gel HPMC hydroxypropyl methylcellulose in some in vitro independent independent of infected with SARS-CoV-2 Infection inhibit SARS-CoV-2 inhibited Intervention limit methylcellulose nasal Nasal cavity Nasal spray Nasal Sprays offer pandemic physical primary mechanism produced product provided reduced required respiratory respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus spray Spread Transmission variant variety virus virus entry virus level virus levels [DOI] 10.3390/v13122345 PMC 바로가기 [Article Type] Communication
Virucidal activity of nasal sprays against severe acute respiratory syndrome coronavirus-2Short Report Published on 2021-11-062023-06-15 Journal: The Journal of hospital infection [Category] COVID19(2023년), MERS, SARS, [키워드] inactivation Nasal spray nasopharynx oral cavity oral spray Quantitative suspension test Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Transmission [DOI] 10.1016/j.jhin.2021.10.019 PMC 바로가기 [Article Type] Short Report
Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: an observational prospective open label user surveyObservational Study Published on 2021-10-012022-10-05 Journal: Expert review of anti-infective therapy [Category] SARS, 임상, [키워드] 95%CI addition cells Community COVID-19 infection COVID19 effective Efficacy Endemic gel Hypromellose infecting Infection ITT low pH Masks Measures Mortality nasal nasal mucosa Nasal spray New objective open label participated prevention Protective reached reduce reduction reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Side effect Spread virus was tested were infected Year [DOI] 10.1080/14787210.2021.1908127 PMC 바로가기 [Article Type] Observational Study
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 MiceK18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과Article Published on 2021-08-202022-08-31 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제, [키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected [DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article
Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infectionComment Published on 2021-08-012023-06-19 Journal: The Journal of Infection [Category] MERS, SARS, [키워드] antimicrobial Antiviral coronavirus COVID-19 Nasal spray nitric oxide prevention SARS-CoV-2 Treatment [DOI] 10.1016/j.jinf.2021.05.009 PMC 바로가기 [Article Type] Comment
Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 managementReview Published on 2021-07-292023-06-15 Journal: Drug discovery today [Category] MERS, SARS, [키워드] antigen-presenting cells (APCs) COVID-19 dendritic cells Nasal spray nasal vaccine SARS-CoV-2 [DOI] 10.1016/j.drudis.2021.07.021 PMC 바로가기 [Article Type] Review
Intranasal gene therapy to prevent infection by SARS-CoV-2 variantsSARS-CoV-2 변이체에 의한 감염을 예방하기 위한 비강내 유전자 요법Research Article Published on 2021-07-152022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] ACE2 administration affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals Antiviral approach bind binding caused Cell combating coronavirus Coronaviruses countermeasure CoV COVID-19 COVID-19 pandemic CoVs demonstrated effective Efficacy evade expression Gene therapy human ACE2 humans immune response improvement infecting Infection Intervention intranasal intranasally less long-lasting monoclonal antibodies monoclonal antibody mouse model nasal Nasal spray neutralize Pandemics pathogenicity pathologic consequence Patient Population pre-existing immunity Prevent Prophylaxis Protein proximal receptor reduce respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral secrete significantly Spread tested the patient therapeutic Transmissibility unlikely vaccination Vaccinations Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations viral particle Viral particles Viral vector virus Vulnerable populations zoonosis [DOI] 10.1371/journal.ppat.1009544 PMC 바로가기 [Article Type] Research Article
Low Acyl Gellan as an Excipient to Improve the Sprayability and Mucoadhesion of Iota Carrageenan in a Nasal Spray to Prevent Infection With SARS-CoV-2Medical Technology Published on 2021-06-162022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] Antiviral antiviral polymer carrageenan common cold Coverage COVID-19 demonstrated excipient gellan global pandemic IMPROVE Influenza interactions investigated Iota mucoadhesion nasal Nasal spray persistence polymers polysaccharide Prevent reducing SARS-CoV-2 significantly spray sulfated Transmission viral infection widespread [DOI] 10.3389/fmedt.2021.687681 PMC 바로가기 [Article Type] Medical Technology
Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19경증 COVID-19의 상부 호흡기 증상을 감소시키는 Ivermectin Mucoadhesive Nanosuspension Nasal Spray의 임상, 생화학적 및 분자 평가Randomized Controlled Trial Published on 2021-06-152022-09-11 Journal: International journal of nanomedicine [Category] 임상, 치료제, [키워드] age Anosmia anti-parasitic assessment assessments biochemical biochemical and molecular biochemical parameter Biochemical parameters Blood C-reactive protein clinical clinical trial Complete complete blood counts cough COVID-19 D-dimer diagnosed dimer Duration Dyspnea effective female Fever gastrointestinal symptoms hematological in vitro inhibit SARS-CoV-2 intranasal Ivermectin ivermectin nanosuspension male Manifestations Mild nasal Nasal spray nasal spray. Nasopharyngeal swab nasopharyngeal swabs Negative PCR negativity nucleic acid Patient performed Pharyngeal swab presenting protocol Randomly Replication respiratory rRT-PCR Safe SARS-CoV-2 replication Serum ferritin shown significant difference significantly shorter spray the patient therapeutic efficacy Treatment upper viral clearance was performed [DOI] 10.2147/IJN.S313093 PMC 바로가기 [Article Type] Randomized Controlled Trial
Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trialCOVID-19 환자의 후각 회복을 위한 코르티코스테로이드 비강 스프레이: 무작위 대조 시험Randomized Controlled Trial Published on 2021-03-012022-08-31 Journal: American journal of otolaryngology [Category] 임상, 치료제, [키워드] Anosmia assigned benefit both group both groups conducted Corticosteroid COVID-19 dose evaluate evaluated full recovery mometasone Mometasone furoate nasal Nasal spray nostril offer olfactory once daily Patient Randomized controlled trial randomized, controlled trial Randomly scale sense of smell significantly Smell Smell loss statistically significant difference suggested Treatment two groups Visual was done was recorded were recorded [DOI] 10.1016/j.amjoto.2020.102884 PMC 바로가기 [Article Type] Randomized Controlled Trial