Omicron BA.2 (B.1.1.529.2): high potential to becoming the next dominating variantArticle Published on 2022-02-102022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] acute respiratory syndrome algebraic Analysis antibody resistance antibody-resistance Beta contagious coronavirus COVID-19 deep learning Delta delta variant evaluate favor Gamma GlaxoSmithKline higher infectivity Infectivity Lambda Lineage mAbs Mutation natural selection omicron Patient question replaced reported SARS-CoV-2 SARS-CoV-2 variant Vaccine Vaccine breakthrough Vaccines variant PMC 바로가기 [Article Type] Article
The evolution of powerful yet perilous immune systems강력하지만 위험한 면역 체계의 진화Review Published on 2022-02-012022-09-12 Journal: Trends in immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition benefit complement coronavirus disease COVID-19 cytokine Cytokines Defense Evolution Evolutionary biology example explain Goldilocks help immune responses immune system immunopathological immunopathology individual Infection mammalian natural selection optimality. predict resource responses suffered susceptibility symbiont [DOI] 10.1016/j.it.2021.12.002 PMC 바로가기 [Article Type] Review
Enhanced High Mutation Rate and Natural Selection to Produce Attenuated Viral Vaccine with CRISPR Toolkit in RNA Viruses especially SARS-CoV-2RNA 바이러스, 특히 SARS-CoV-2에서 CRISPR 툴킷을 사용하여 약독화 바이러스 백신을 생산하기 위한 향상된 높은 돌연변이율 및 자연 선택Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] accelerate Attenuated vaccines Cell change changes in coculture condition CRISPR CRISPR toolkit effective effective vaccine Effective vaccines Efficiency enhanced Genome Live attenuated vaccine Live attenuated vaccines natural natural selection Palindromic Pandemics Point Point mutation point mutations problem Produce Rate RNA RNA virus RNA viruses RNA viruses. SARS-CoV-2 Selection speed toolkit [DOI] 10.1016/j.meegid.2021.105188 PMC 바로가기 [Article Type] Article
RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in BetacoronavirusArticle Published on 2022-01-012022-11-16 Journal: RNA Biology [Category] 변종, [키워드] analysed analysis Antiviral bat bat virus bats Betacoronavirus build changes in coding complement conserved cross-species horizontal transmission D614G develop disrupt events Factor function Genome genome-wide analysis Health hosts hotspot Human Impact in viral information investigated jumping the species barrier MERS-CoV Missense mutation molecular molecular evolution Mutation natural selection overlap Positive selection Protein Proteins Research reservoir RNA RNA genome RNA structure RNA structures RNA viruses S protein SARS-CoV SARS-CoV-2 secondary RNA structures selected small RNA spike Surveillance the Betacoronavirus the S protein Therapeutic strategies Transmission viral genome Viral proteins viral RNA genome viral RNA genome. Viral transmission [DOI] 10.1080/15476286.2022.2115750 PMC 바로가기
Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America유럽과 미국에서 백신 내성 돌연변이를 드러내는 SARS-CoV-2 진화 메커니즘Article Published on 2021-12-162022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] America antibody binding domain can not complementary disrupt domain drugs Europe favor Frequency mechanism Mutation mutations N501Y natural selection neutralize occurred Occurrence omicron pathway Protein recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate vaccination rates Vaccine Viral viral evolution viral infectivity virus [DOI] 10.1021/acs.jpclett.1c03380 PMC 바로가기 [Article Type] Article
Identification of a novel SARS-CoV-2 P.1 sub-lineage in Brazil provides new insights about the mechanisms of emergence of variants of concernResearch Article Published on 2021-12-152022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accounted accumulated acute respiratory syndrome affected analysis Brazil circulating complex interplay coronavirus described dissemination driving Epidemic Factor feature fixed fraction Gamma Genomic surveillance Hypothesis identification Lineage lineage P.1 mechanism Mutation natural selection new SARS-CoV-2 P.1 partial immunity Protein provide RBD RBD mutation reconstruction Region resolved SARS-CoV-2 SARS-COV-2 infection sequence strain subsequent Support the receptor-binding domain the S protein the Spike trajectory Transmission variant variant of concern Gamma variants of concern viral spread VoC VOCs [DOI] 10.1093/ve/veab091 PMC 바로가기 [Article Type] Research Article
Controlling long-term SARS-CoV-2 infections can slow viral evolution and reduce the risk of treatment failure장기간 SARS-CoV-2 감염을 통제하면 바이러스 진화를 늦추고 치료 실패 위험을 줄일 수 있습니다Article Published on 2021-11-192022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] controlling convalescent plasma COVID-19 Critical event Evolution expansion favor herd immunity immune evasion Immunity Immunocompromised individual Infection infections Infectious diseases lead mutations natural selection occur patient population population level Prevent Probability reduce risk SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants subsequent targeting the patient traits Transmissibility Transmission treated Treatment variant variants variants of SARS-CoV-2 Viral viral evolution Viral load viral variant while [DOI] 10.1038/s41598-021-02148-8 PMC 바로가기 [Article Type] Article
The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and AmericaArticle Published on 2021-10-092022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] America antibody complementary COVID-19 disrupt domain drugs Europe Evolution favor Frequency Infectivity mechanism Mutation natural selection neutralize occurred Occurrence pathway Protein RBD recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate Vaccine vaccine-breakthrough vaccine-resistant mutation viral evolution viral infectivity virus Y449S PMC 바로가기 [Article Type] Article
Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energySARS-CoV-2의 잠재적인 아킬레스건은 RNA 접힘 에너지의 기본 순서 종속 구성 요소에 의해 가장 잘 표시됩니다.Article Published on 2021-10-012022-09-11 Journal: Computational biology and chemistry [Category] SARS, 치료법, [키워드] Achille AIDS Antiviral compound conserved conserved region coronavirus domain FORS-D analysis function Gag Genome heel HIV-1 indicate Long natural selection nsp13 Nsp3 nucleic acid nucleocapsid ORF3a polyprotein Potential Protein Region regions RNA RNA packaging signal RNA structure SARS-CoV-2 scored Sequence conservation signal stem-loop Stem-loop potential. susceptible sustained therapy while [DOI] 10.1016/j.compbiolchem.2021.107570 PMC 바로가기 [Article Type] Article
New insights into human immunity from ancient genomics고대 유전체학에서 인간 면역에 대한 새로운 통찰력Review Published on 2021-10-012022-09-11 Journal: Current opinion in immunology [Category] SARS, 유전자 메커니즘, [키워드] admixture analyses COVID-19 disease Defense Diseases DNA Epidemics Evolution form function functions Genetic studies genetic study Host host defense Human human immunity human populations humans hybridization immune immune gene immune genes immune response Immunity indicated infectious agents natural selection Neanderthal New Pathogens Population reported Sequencing severe COVID-19 disease subject susceptibility Variation [DOI] 10.1016/j.coi.2021.04.006 PMC 바로가기 [Article Type] Review