REGN-COV2 antibody cocktail in patients with SARS-CoV-2: Observational study from a single institution in JapanSARS-CoV-2 환자의 REGN-COV2 항체 칵테일: 일본 단일 기관의 관찰 연구Observational Study Published on 2022-07-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome addition Administered adverse effect antibody cocktail approved Casirivimab Comorbidity coronavirus coronavirus disease COVID-19 death diabetes diagnosed with COVID-19 disease onset duration of symptom Hospitalization hypertension Imdevimab investigated Japan monoclonal neutralizing antibody neutralizing monoclonal antibodies obesity observational study oxygen saturation Patient REGN-CoV2 risk risk factor Safe SARS-CoV-2 severe COVID-19 severe disease Severe infection treated Treatment [DOI] 10.1016/j.jiac.2022.03.029 PMC 바로가기 [Article Type] Observational Study
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment증례 보고: SARS-CoV-2 감염이 오래 지속된 APDS 환자 1명에서 단일클론항체로 성공적인 치료Case Reports Published on 2022-06-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activated activated PI3K delta syndrome (APDS) administration affected APDS clearance COVID19 described Efficacy first positive genotyping IEI Infection LINE long-lasting long-lasting infection monoclonal monoclonal antibodies monoclonal antibody multiple therapeutic agent multiple therapeutic agents neutralizing monoclonal antibodies other treatments Patient pauci-symptomatic PI3K Prolonged reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Swab syndrome tested the SARS-CoV-2 virus therapeutic agents Tolerability treated Viral viral shedding virus wild type [DOI] 10.3389/fimmu.2022.891274 PMC 바로가기 [Article Type] Case Reports
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccineesCOVID-19 mRNA 백신에 있는 Omicron BA.1 및 BA.2 중화 항체의 해부학Article Published on 2022-06-132022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered antibody BNT162b2 BNT162b2 mRNA vaccine class conserved COVID-19 COVID-19 pandemic cross-neutralize cross-neutralizing antibodies cross-neutralizing antibody cross-protection Donor Effect elicited epitope Epitopes Evidence germlines IGHV1-58 IGHV1-69 IGHV2-5 mitigate molecular molecular basis mRNA mRNA vaccine NAb NAbs neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody not neutralize NTD omicron other coronaviruses predominant question RBD Receptor binding domain recognize Region S protein SARS-CoV-1 SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccines seronegative seropositive Spike protein tested the S protein the SARS-CoV-2 vaccination Vaccine design vaccinee Vaccines variants variety virus Wuhan [DOI] 10.1038/s41467-022-31115-8 PMC 바로가기 [Article Type] Article
Combination anti-HIV antibodies provide sustained virological suppression Research Published on 2022-06-012022-10-05 Journal: Nature [Category] 바이오마커, 임상, 치료제, [키워드] Administered antibody Antiretroviral therapy antiviral agent baseline clinical trial clinically Combination combination therapy Complete develop double-blind effective enrolled Guidance half-lives HIV HIV infection Human immunodeficiency virus individual inhibit initiated neutralizing monoclonal antibodies neutralizing monoclonal antibody offer Open-label participant Placebo placebo-controlled trial plasma provided Randomized Serious Adverse Event single-arm trial study participant Study participants sustained therapy transfer Treatment Viraemia virological suppression virus with HIV [DOI] 10.1038/s41586-022-04797-9 [Article Type] Research
The impact of neutralizing monoclonal antibodies on the outcomes of COVID-19 outpatients: A systematic review and meta-analysis of randomized controlled trials중화 단일클론항체가 COVID-19 외래 환자의 결과에 미치는 영향: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] 임상, 진단, [키워드] 95% confidence interval addition adverse event adverse events AEs article clinical Clinical efficacy Cochrane Library control group controlled trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outpatient COVID-19 outpatients database emergency department Health Organization help higher risk Hospitalization ICTRP inception lower risk mAbs Meta-analysis monoclonal mortality rate Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody Odds ratio Odds ratios outcome Outpatient outpatients Patient patients Placebo Primary outcome Randomized controlled trial RCTs reduce registry risk risk of death Safe Safety searched secondary outcome Secondary outcomes serious AE serious AEs significantly lower systematic review the patient Treatment was used Web of Science World Health Organization [DOI] 10.1002/jmv.27623 PMC 바로가기 [Article Type] Meta-Analysis
Functional reconstitution of the MERS CoV receptor binding motifMERS CoV 수용체 결합 모티프의 기능적 재구성Article Published on 2022-05-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E beta-coronaviruses catastrophic caused Co-infection Combinatorial phage display common cold coronavirus Coronaviruses CoV COVID-19 develop disease Diseases epitope Epitope reconstitution Epitope-based vaccine etiologic agent event Evolution Fatality rate followed by Human human coronavirus human-to-human transmission Implementing incidence independent Isolation less life-threatening MERS MERS CoV. Middle East neutralizing monoclonal antibodies OC43 omicron Omicron variants pandemic Population Prevalence Protein RBM receptor binding motif Recombination reported Respiratory disease respiratory diseases SARS CoV Saudi Arabia Seven shown spike Spike protein subsequent summer variants of concern viruses [DOI] 10.1016/j.molimm.2022.03.006 PMC 바로가기 [Article Type] Article
Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2SARS-CoV-2의 오미크론 변이체에 대한 백신 보조제로서의 멜라토닌 및 REGN-CoV2 조합Review Published on 2022-05-012022-09-11 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvant therapy affected antioxidant Antiviral caused cocktail Combination contagiousness coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm delta variant develop elderly patients evaluate Immunocompromised immunomodulatory effects less mAb mAb cocktails mAbs melatonin multiple mutation multiple mutations Mutation neutralizing monoclonal antibodies neutralizing monoclonal antibody omicron Omicron variant Panic Prevent prevention of COVID-19 RBD Receptor binding domain Regeneron REGN-CoV2 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom shown Spike protein the spike protein therapy traction treat Treatment Vaccine variant of SARS-CoV-2 Viral viral invasion [DOI] 10.1007/s11033-022-07419-9 PMC 바로가기 [Article Type] Review
COVID-19 in dialysis: clinical impact, immune response, prevention, and treatment투석에서의 코로나19: 임상적 영향, 면역 반응, 예방 및 치료Review Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료법, [키워드] absence adenoviral vector vaccine adverse effect antibody antibody levels BNT162b2 BNT162b2 vaccine booster dose candidate Candidates Care clinical impact Course COVID-19 COVID-19 pandemic develop dialysis disease severity dose Evidence Hemodialysis Hospitalization humoral immune response immune Immune escape immune response immune responses Immunity immunogenicity increase increased risk Infection initial long-lasting monoclonal antibody Mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine neutralizing monoclonal antibodies Patient Preliminary data prolonged viral shedding Prophylaxis PROTECT Psychological distress Reinfection responses reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 variant SARS-CoV-2 variants severe disease significantly survivor Therapeutic strategies therapeutic strategy Treatment vaccination vaccine response Viral viral shedding virtue [DOI] 10.1016/j.kint.2022.01.022 PMC 바로가기 [Article Type] Review
Evidence-based dosing of convalescent plasma for COVID-19 in future trials향후 시험에서 COVID-19에 대한 회복기 혈장의 증거 기반 투여Review Published on 2022-05-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody Antibody test CLOCK convalescent plasma ConvP coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Donor Donor selection donors dose doses Dosing Efficacy Evidence Guidance identifying Immunity International international units monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination neutralize neutralizing antibody neutralizing antibody titres neutralizing monoclonal antibodies omicron Omicron variant pandemic Patient care performed Pharmacodynamics pharmacokinetics plasma unit premise respiratory SARS-CoV-2 selection process Support the patient therapy titre Treatment Trial turn variant variants Virus neutralization virus-neutralizing virus-neutralizing antibody Volume [DOI] 10.1016/j.cmi.2022.01.026 PMC 바로가기 [Article Type] Review
Antibody evasion properties of SARS-CoV-2 Omicron sublineagesSARS-CoV-2 오미크론 하위 계통의 항체 회피 특성Article Published on 2022-04-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody antigenic bebtelovimab caused comparable coronavirus Efficacy Evolution except for exhibited include lead monoclonal antibodies monoclonal antibody monoclonal antibody therapy mRNA vaccine Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody omicron Omicron variant Patient polyclonal sera Prevalence recipient recipients refs reported respiratory retained S309 SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus Sotrovimab spike glycoprotein Surveillance tested therapy unique Vaccines variant wild-type SARS-CoV-2 [DOI] 10.1038/s41586-022-04594-4 PMC 바로가기 [Article Type] Article