NK, natural killer – Page 2 – Communicable Diseases Research

The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19

Review

Published on 2021-02-042023-06-16
Journal: Gene [Category] MERS, SARS,

Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic

Review

Published on 2021-01-132023-07-01
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS,

[키워드] 3CLpro, 3C-like protease ACE2, angiotensin-converting enzyme 2 ADME, absorption, distribution, metabolism, and excretion angiotensin-converting enzyme 2 CC50, half-cytotoxic concentration COVID-19 CoVs, coronaviruses E, envelop EC50, half-maximal effective concentration FDA, Food and Drug Administration Hel, helicase hrsACE2, human recombinant soluble ACE2 HTS, High Through-put Screening IC50, Half maximal inhibitory concentration M, membrane Main and papain-like proteases MERS-CoV, Middle East respiratory syndrome (MERS) coronavirus MERS, Middle East respiratory syndrome Mpro, Main protease N, nucleocapsid NiRAN, Nucleotidyl-transferases NK, natural killer NSP, non-structural protein PLpro, papain-like protease RBM, receptor binding motif RdRp, RNA-dependent RNA polymerase Repurposing and de novo strategies RNA-dependent-RNA-polymerase S, spike SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome (SARS) coronavirus SARS, Severe acute respiratory syndrome SI, selective index Spike protein TCM, traditional Chinese medicine TMPRSS2, the transmembrane protease, serine 2
[DOI] 10.1016/j.biopha.2021.111232 PMC 바로가기 [Article Type] Review

Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection

Review

Published on 2021-01-052023-07-02
Journal: Journal of advanced research [Category] SARS,

Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy

Article

Published on 2020-12-152023-06-15
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 ALI, Acute Lung Injury ARDS, acute respiratory distress syndrome BBB, blood-brain-barrier BM-MSC, bone marrow mesenchymal stromal cells CD, Crohn’s disease CM, conditioned-medium CNS, Central Nervous System COVID-19 COVID-19, Coronavirus disease of 2019 Cytokine storm cytokines/chemokines DCs, dendritic cells EVs, extracelular vesicules FDA, US Food and Drug Administration FGF7, fibroblast growth factor 7 GI, gastrointestinal GMCSF, Granulocyte-macrophage colony-stimulating factor IBD, Inflammatory bowel disease IDO, indoleamine 2,3 dioxygenase IFN-y, interferon y IL, interleukin IV, Intravenous JEV, Japanese encephalitis virus LPS, lipopolysaccharide LVEF, left ventricle ejection fraction MB-MSC, menstrual blood mesenchymal stromal cells MCP-1, monocyte chemoattractant protein 1 MERS, Middle East respiratory syndrome mesenchymal stromal/stem cells MSC, mesenchymal stromal cells NK, natural killer Pleiotropic therapy SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome Th, T helper TMPRSS2, Transmembrane Protease Serine 2 TNF-a, tumor necrosis factor alpha Treg, T regulatory VEGF, vascular endotelhial growth factor
[DOI] 10.1016/j.cytogfr.2020.12.002 PMC 바로가기 [Article Type] Article

Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

Review Article

Published on 2020-10-102023-06-15
Journal: Life sciences [Category] MERS, SARS,

[키워드] ACE-2 receptor ACE2, Angiotensin-converting enzyme 2, acute respiratory distress syndrome Ag I, Angiotensin I ARSD, Acute respiratory distress syndrome AT-II, Alveolar epithelial type 2 cells AT1 R, Angiotensin receptor type I CD, cluster of differentiation CD209L, C-type 209 lecithin CM, Conditioned media COVID-19 COVID-19, Coronavirus disease 2019 DAMPs, Damage associated molecular patterns G-CSF, Granulocyte colony-stimulating growth factor GVHD, Graft-versus-host disease HLA, human leukocyte antigen IDO, Indoleamine 2,3-dioxygenase IFN- β, Interferon- β Ig E, Immunoglobulin E IL, interleukin immunomodulation IRF-3, Interferon regulatory factor-3 KGF, Keratinocyte growth factor Lung fibrosis MCP-1, Monocyte chemoattractant protein MERS-Cove, Middle East respiratory syndrome coronavirus Mesenchymal stem cells MIP, macrophage inflammatory protein MSC's, Mesenchymal stem cells MV's, Microvesicles NK, natural killer PAMPs, Pathogen-associated molecular pattern PGE-2, Prostaglandin E2 RAGE, Receptor for advanced glycation end products RAS, Renin-angiotensin system RT-qPCR, Reverse transcription real-time nucleic acid polymerase reaction: SARS-CoV-2 SARS-CoV-2, Severe Acute Respiratory Syndrome novel Cornovirus-2 SARS-CoV, severe acute respiratory syndrome coronavirus SLE, Systemic lupus erythematous TGF- β, Transforming growth factor- β TNF-α, Tumour necrosis factor WHO, World Health Organization
[DOI] 10.1016/j.lfs.2020.118588 PMC 바로가기 [Article Type] Review Article

Predictive monitoring and therapeutic immune biomarkers in the management of clinical complications of COVID-19

Review

Published on 2020-10-092023-06-15
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

[키워드] AAK-1, activated protein (AP) 2 associated kinase 1 Ab, antibody ACE, angiotensin-converting enzyme ACEI, ACE inhibitor AEC, alveolar epithelial cells AICD, activation-induced cell death Ang, angiotensin APC, Antigen-Presenting Cell aPTT, activated partial thromboplastin time ARB, Ang II receptor blocker ARDS, acute respiratory distress syndrome AT1R, Ang II receptor type 1 BALF, bronchoalveolar lavage fluid BEC, Bronchial epithelial cell Biomarker BTK, Bruton tyrosine kinase C-GAS-STING, cGAMP binds to stimulator of interferon genes C3 and C5, complement proteins CCL, chemokine (C-C motif) ligand CCR, chemokine (C-C motif) ligand receptor ChiCTR, Chinese Clinical Trial Registry complications COVID-19 COVID-19, coronavirus disease-2019 CP, convalescent plasma CQ, Chloroquine CRP, C-reactive protein CRS, Cytokine release syndrome CT, Computerized Tomography CTL, cytotoxic T lymphocyte CXCL, Chemokine (C-X-C motif) ligand CXCR, chemokine (C-X-C motif) ligand receptor Cytokine storm DIC, disseminated intravascular coagulation dsRNA, double-stranded RNA ESR, Erythrocyte sedimentation rate FcγR, Fc gamma receptor Fio2, fraction of inspired oxygen GAK, G-associated kinase GM-CSF, granulocyte-macrophage colony-stimulating factor GzmB, granzyme B HCQ, hydroxychloroquine HLA, human leukocyte antigen HLH, Hemophagocytic lymphohistiocytosis HR-2, heptad repeat region-2 ICU, admissions to intensive care units IFITM, Interferon-induced transmembrane protein IFN, interferon IL, interleukin immunopathology IP-10, interferon (IFN)-γ inducible protein-10 IRF-1, IFN regulatory factor 1 ISG, induction of IFN-stimulated gene IVIG, intravenous immunoglobulin JAK, Janus kinase JUN, c-Jun N-terminal kinases KL-6, Krebs von den Lungen-6 LAG-3, Lymphocyte-activation gene 3 LDH, lactate dehydrogenase lung LWR, lymphocyte-to-WBCs ratio LY6E, lymphocyte antigen 6 family member E mAb, monoclonal antibody MCP, monocyte chemoattractant protein MDA-5, melanoma differentiation-associated protein-5 MERS, Middle East respiratory syndrome MIP, macrophage inflammatory proteins MOF, Multiple organ failure MUC, mucin N, nucleocapsid nAb, Neutralizing Antibody NCT, clinicaltrials.gov identifier NFkB, nuclear factor kappa-light-chain-enhancer of activated B cells NK, natural killer NKRF, NFkB repressing factor NLR, neutrophil-to-lymphocyte ratio NLRP3, nod-like receptor protein 3 NSP, Non-structural Proteins NTD, N Terminal Domain ORF-1ab, open reading frame 1ab Pao2, partial pressure of oxygen PCT, procalcitonin PD1, programmed cell death protein 1 PKR, protein kinase R PLR, platelet-to-lymphocyte ratios PRR, Pattern Recognition Receptors PT, prothrombin time RA, Rheumatoid arthritis RAS, regulator of the renin-angiotensin system RBD, receptor-binding domain rBP-C33Leu, recombinant surfactant protein C analogue rhACE2-Fc fusion proteins, recombinant human ACE2-Fc fusion proteins rhIL-1ra, recombinant human IL-1 receptor RIG, retinoic acid-inducible gene-I rIL7, recombinant IL-7 RLR, RIG-I-like receptors RT-qPCR, real time-quantitative PCR S-protein, spike-protein S1PR, sphingosine-1-phosphate receptors SAA, serum amyloid A SARS-CoV, severe acute respiratory syndrome coronavirus SARS, severe acute respiratory scFv, single-chain variable fragment siRNA, small interfering RNA SP, surfactant SPo2, arterial oxygen saturation srhACE2, soluble recombinant human (srh)ACE2 ssRNA, single-stranded RNA TGF, Transforming growth factor Th, helper T cell TIM-3, T-cell immunoglobulin mucin 3 TLR, Toll like Receptor TMPRSS2, Transmembrane serine protease 2 TNF-α, tumor necrosis factor Treg, regulatory T cells VEGF, Vascular endothelial growth factor WBC, White blood cell
[DOI] 10.1016/j.cytogfr.2020.10.002 PMC 바로가기 [Article Type] Review

Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle

Review

Published on 2020-10-032023-06-14
Journal: Phytomedicine : international journal of phytother [Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme ACTH, adrenocorticotrophic hormones APC, antigen presenting cell ARC, artepillin C ARDS, acute respiratory distress syndrome ASCs, antibody-secreting cells AYUSH, ayurvedic, yoga and naturopathy, unani, siddha and homeopathy C-1, Caspase-1 CAPE, caffeic acid phenyl ester CHM, Chinese herbal medicine GCSF, granulocyte-colony stimulating factor Herbal plants ICTV, International Committee on Taxonomy of Viruses IGG, immunoglobulin g IGM, immunoglobulin m IL, interleukin Immune-System Rebooting MAPK, mitogen activated protein kinases MCP1, monocytechemoattractant protein 1 MERS-CoV, Middle East respiratory syndrome MIP1, macrophage inflammatory protein 1 MT, metalloprotease MVD, molegro virtual docker Natural therapeutics NF, neuro fibromatosis NK, natural killer NLR, neutrophil-to-lymphocyte ratio NLRP3, NOD-like receptor proteins PAK-1 Blockers PDB, Protein Data Bank R₀, basic reproduction number RBD, receptor-binding domain RNA, Ribonucleic acid SARS-CoV-2 SARS-COV-2, severe acute respiratory syndrome coronavirus-2 SARS-CoV, severe acute respiratory syndrome TCM, traditional Chinese medicines Tfh, follicular helper T-cells TNF, Tumor Necrosis Factor Traditional medicine WHO, World Health Organisation
[DOI] 10.1016/j.phymed.2020.153361 PMC 바로가기 [Article Type] Review

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

Review Article

Published on 2020-07-312023-06-15
Journal: Life sciences [Category] MERS, SARS,

[키워드] ACE, Angiotensin converting enzyme AM, alveolar macrophages AP, activated platelets ARDS, acute respiratory distress syndrome BALF, bronchoalveolar lavage fluids CFR, case fatality rates COVID-19 CXCL10, C-X-C motif chemokine 10 DAMPs, damage-associated molecular patterns DIC, disseminated intravascular coagulation EC, endothelial cell GM-CSF, granulocyte-macrophage colony-stimulating factor HMBG1, high mobility group box 1 HMG-1, high-mobility group protein 1 IL, interleukin MAC-1, macrophage-1 antigen MAPKs, mitogen-activated protein kinases MCP-1, monocyte Chemoattractant Protein-1 MDSC, CD11b + Gr-1+ myeloid-derived suppressor cells MERS, Middle East respiratory syndrome MPO, myeloperoxidase NETs, neutrophil extracellular traps NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NK, natural killer NLRs, NOD-like receptors NO, Nitric Oxide PF4, platelet factor 4 PFA, polyenoic fatty acids PGE2, Prostaglandin E2 PI3K, phosphoinositide 3-kinase PICs, proinflammatory cytokines PNC, platelet neutrophil complexes PSGL-1, P-selectin glycoprotein ligand-1 RAGE, receptor for advanced glycation endproducts respiratory infection ROS, reactive oxygen species SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 T reg, regulatory T cell TF, Tissue factor TGF, Transforming growth factor TLR, Toll-like receptor 9 TMPRSS2, transmembrane protease, serine 2 TNF, Tumor Necrosis Factor Treatment URT, upper respiratory tract WHO, World Health Organisation Zn, zinc
[DOI] 10.1016/j.lfs.2020.118166 PMC 바로가기 [Article Type] Review Article

Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China

Article

Published on 2020-06-092022-10-04
Journal: Virus research [Category] SARS, 치료법, 치료제,

[키워드] ACE2, angiotensin converting enzyme II ACE2angiotensin converting enzyme II activities acute respiratory distress syndrome Adverse reactions angiotensin converting enzyme II ARDS, acute respiratory distress syndrome ARDSacute respiratory distress syndrome articles Biological Biological products C-reactive protein cellular Characteristics Chemical drugs China China National Knowledge Infrastructure Chinese chronic obstructive pulmonary disease clinical trial clinical trials CNKI CNKI, China National Knowledge Infrastructure CNKIChina National Knowledge Infrastructure convalescent plasma COPD, Chronic obstructive pulmonary disease COPDchronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19, Coronavirus disease 2019 COVID-19coronavirus disease 2019 CP, convalescent plasma CPconvalescent plasma CRP, C-reactive protein CRPC-reactive protein database dengue virus DENV, dengue virus DENVdengue virus drug drugs EC50, half effective concentration EC50half effective concentration effective drugs Effects Efficacy and safety Fangfeng Tongsheng Pill FFTS, Fangfeng Tongsheng Pill FFTSFangfeng Tongsheng Pill filtered GA, glycyrrhizic acid GAglycyrrhizic acid glycyrrhizic acid Government half effective concentration Health HIV, Human immunodeficiency virus HIVhuman immunodeficiency virus HSBD, Huashi Baidu Prescription HSBDHuashi Baidu Prescription Huashi Baidu Prescription Human immunodeficiency virus Huoxiang Zhengqi HXZQ, Huoxiang Zhengqi HXZQHuoxiang Zhengqi IFN-α, interferon-α IFN-αinterferon-α indications Infrastructure ingredient injection Interferon-α JHQG, Jinhua Qinggan Granule JHQGJinhua Qinggan Granule Jiedu Capsule Jinhua Qinggan Granule large sample LHQW, Lianhua Qingwen Capsule LHQWLianhua Qingwen Capsule Lianhua Qingwen capsule medication MERS-CoV, Middle East respiratory syndrome coronavirus MERS-CoVmiddle east respiratory syndrome coronavirus Mesenchymal stem cells Middle East respiratory syndrome Coronavirus MNV, murine norovirus MNVmurine norovirus MSCs, mesenchymal stem cells MSCsmesenchymal stem cells murine norovirus natural killer NCP, novel coronavirus pneumonia NCPnovel coronavirus pneumonia NK, natural killer NKnatural killer Novel coronavirus novel coronavirus pneumonia pharmacological Pneumonia Potential QFPD, Qingfei Paidu Decoction QFPDQingfei Paidu Decoction Qingfei Paidu decoction Randomized controlled trials RCTs, randomized controlled trials RCTsrandomized controlled trials researcher respiratory syncytial virus ribofuranosyl-5′-triphosphate RSV, respiratory syncytial virus RSVrespiratory syncytial virus RTP, ribofuranosyl-5′-triphosphate RTPribofuranosyl-5′-triphosphate SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus SARS-CoVsevere acute respiratory syndrome coronavirus searched severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Shufeng SFJD, Jiedu Capsule Shufeng SFJDJiedu Capsule stem cells TCM TCMs, traditional Chinese medicines TCMstraditional Chinese medicines therapeutic effect TJQW, Toujie Quwen Granule TJQWToujie Quwen Granule Toujie Quwen granule Traditional Chinese medicine traditional Chinese medicines treat Treatment Vaccines XFBD, Xuanfei Baidu Decoction XFBDXuanfei Baidu Decoction Xuanfei Baidu Decoction
[DOI] 10.1016/j.virusres.2020.198057 PMC 바로가기 [Article Type] Article

COVID-19: Unanswered questions on immune response and pathogenesis

Article

Published on 2020-05-082023-06-15
Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 Anti–SARS-CoV-2 immunity COVID-19 pathogenesis COVID-19, Coronavirus disease 2019 IC, Intensive care IFN-1, Type I interferon nAb, Neutralizing Antibody NK, natural killer RBD, receptor-binding domain rCoV, Respiratory coronavirus SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Viral immune evasion
[DOI] 10.1016/j.jaci.2020.05.001 PMC 바로가기