NK, natural killer – Communicable Diseases Research

Effect of SARS-CoV-2 infection in pregnancy on CD147, ACE2 and HLA-G expression

Article

Published on 2023-01-052024-09-05
Journal: Placenta [Category] update2024,

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

Article

Published on 2021-10-152022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

[키워드] accompanied ACE2, angiotensin-converting enzyme II Activation acute respiratory distress acute respiratory syndrome ADAM17, metalloprotease 17 alarmin ALI, acute lung injuries approach AT1R, activation of angiotensin-1-receptor BAFFR, B-cell activating factor receptor BLC, B-lymphocyte chemoattractant bortezomib c-AMP, cyclic adenosine phosphate CASP3, caspase 3 CCL, chemokine ligand CD40⁺, cluster of differentiation 40 CDC, Center for Disease Control and Prevention chemokine coronavirus disease Coronavirus-2 Corticosteroid cough CoV, coronavirus COVID-19 COVID-19, Coronavirus disease 2019 COX-2, cyclooxygenase-2 cross-talk CRP C, reactive protein CTLs, cytotoxic T lymphocytes CXCL C-X-C, motif chemokine ligand CXCL, C-X-C- motif chemokine cytokine Cytokine storm Cytokine storm syndrome DAMP, damage-associated molecular patterns (DAMP) demonstrated Dexamethasone Diseases Dyspnoea dysregulated Effectiveness Enzymes ERK1/2, extracellular signal-regulated kinases expression feature Fever GSDMD, Gasdermin highlight Host Host immune response IKK, IκB kinase IL-1R, Interleukin 1 receptor (IL-1R) IL, interleukin immune dysregulation immune system Inflammation Inflammatory cytokine inhibitor iNOS, nitric oxide synthase IP-10, interferon-inducible protein 10 JAK, Janus kinase JNK, Jun amino-terminal kinases life-threatening LPS, lipopolysaccharides LTβR, Lymphotoxin-β receptor manifestation MAPK, Mitogen-activated protein kinase MAPKs, mitogen-activated protein kinases MCP-1, monocyte chemoattractant protein 1 MIG, monokine induced by interferon-γ MIP-1α and MIP-1β, macrophage inflammatory protein 1α and 1β, respectively monoclonal antibody morbidity and mortality multiple organ failure NEMO, regulatory subunit IKKγ NF-κB NF-κB, nuclear factor kappa B cells NF-κB NK, natural killer NO, Nitric Oxide Novel coronavirus nucleotide offer PAMPs, pathogen-associated molecular patterns pathway PKR, threonine-derived kinases pro-inflammatory mediators PTMs, post-translational modifications RANK, receptor activator of NF-κB Remdesivir responsible RSV, respiratory syncytial virus SARS-CoV-2 SARS, Severe acute respiratory syndrome Septic shock Severe acute respiratory syndrome severe complication severe COVID-19 patients Signal transduction significant decrease SMD, SOD, superoxide dismutase STAT3, signal transduction activator of transcription factor 3 STING, stimulator of interferon genes syndrome systemic inflammation Th, helper T cells therapeutic intervention therapeutic strategy therapy TLR-4, Toll-like receptor-4 TNF-α TNF, Tumour Necrosis Factor TNFR, tumour necrosis factor receptor tyrosine upregulating VEGF, Vascular endothelial growth factor
[DOI] 10.1016/j.intimp.2021.108255 PMC 바로가기 [Article Type] Article

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Article

Published on 2021-09-132022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

[키워드] “cytokine storm” A1, adenosine 1 receptor A2A, adenosine 2A receptor A2B, adenosine 2B receptor A3, adenosine 3 receptor Abstract ACE2 ACE2, angiotensin II-converting enzyme ACh, Acetylcholine Activation acute respiratory syndrome ADA, adenosine deaminase adenosine Ado, adenosine nucleoside ADP, adenosine diphosphate AEC, alveolar epithelial cell AK, adenosine kinase ALP, alkaline phosphatases alveolar epithelial cell AM, alveolar macrophages AMP, adenosine monophosphate APC, antigen presenting cell ARDS, acute respiratory distress syndrome ATP ATP, adenosine triphosphate binding CCL, chemokine ligand with CC motif CD, cluster of differentiation CDC, Centers for Disease Control and Prevention characterized CLR, C-type lectin receptor CNS, Central Nervous System CNT, concentrated nucleoside transporters COPD, Chronic obstructive pulmonary disease coronavirus coronavirus disease cough COVID-19 COVID-19, coronavirus disease CT, Computed tomography cytokine DAMP, danger-associated molecular pattern death Defense difficulty breathing E protein, envelope protein E-5′-NT, ecto-5′-nucleotidase E-NPP, ectonucleotide pyrophosphatase/ phosphodiesterase E-NTPDase, ectonucleoside triphosphate diphosphohydrolase effective ENT, balanced nucleoside transporters enzyme etiological agent expressed FDA, Food and Drug Administration Fever G-CSF, granulocyte colony-stimulating factor GABA, γ-amino butyric acid GVHD, Graft-versus-host disease H1N1, influenza type A subtype H1N1 virus HIF, hypoxia-inducible factor ICTV, International Committee on Taxonomy of Viruses ICU, Intensive care unit IFN-γ, interferon gamma IFN-I, type I interferon IGG, immunoglobulin g IGM, immunoglobulin m IL-1β, interleukin 1 beta IL, interleukin immune immune cells immune system infecting Infection Inflammation Interaction involved IP-10, interferon gamma-induced protein 10 IPF, Idiopathic pulmonary fibrosis Lung disease M protein, membrane protein MCP-1, monocyte chemotactic protein 1 mechanism MERS-CoV, Middle East respiratory syndrome MHC-I, major histocompatibility complex class I MHC-II, major histocompatibility complex class II MIP-1α, macrophage inflammatory proteins 1-alpha modulation N protein, nucleocapsid protein NAc, nucleus accumbens NET, neutrophil extracellular traps NK, natural killer NLRP3, NOD-, LRR- and pyrin domain-containing protein 3 organ P1, type 1 purinergic receptor P2, type 2 purinergic receptor P2X7 pandemic Pneumonia Protein purinergic signaling receptor receptors reduce Replication respiratory tract responsible RNA, Ribonucleic acid ROS, reactive oxygen species RT-PCR, Reverse transcription polymerase chain reaction S protein, spike protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 virus SARS-CoV, severe acute respiratory syndrome coronavirus SARS, Severe acute respiratory syndrome severity Signaling single-stranded RNA virus suppress targeting the Coronaviridae the cytokine storm the disease therapy tissue TNF-α, tumor necrosis factor alpha Treatment Trigger viral surface virus WHO, World Health Organization with COVID-19
[DOI] 10.1016/j.intimp.2021.108150 PMC 바로가기 [Article Type] Article

Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice

Review

Published on 2021-09-082023-07-01
Journal: Human immunology [Category] SARS,

[키워드] ACE, Angiotensin converting enzyme ADCC, antibody-dependent cellular cytotoxicity Adoptive Cell Therapy ARDS, acute respiratory distress syndrome CAR-NK, Chimeric antigen receptor-NK CD8⁺ T cell Coronavirus disease 2019 (COVID-19) COVID-19, Corona virus disease 2019 CRS, Cytokine release syndrome Cytokine storm DCs, dendritic cells DNAM, DNAX Accessory Molecule G-CSF, granulocyte-colony stimulating factor GM-CSF, Granulocyte macrophage colony-stimulating factor HLA, human leukocyte antigen ICAM, intercellular adhesion molecule ICU, Intensive care unit IFN, interferon IL, interleukin innate immune response IP-10, IFN-γ-inducible protein 10 KIRs, Killer immunoglobulin-like receptors MCP, monocyte chemoattractant protein MDA, Melanoma differentiation-associated protein Memory cells MERS, Middle East respiratory syndrome MHC, Major histocompatibility MIG, Monokine induced by gamma interferon MIP, macrophage inflammatory protein NCRs, Natural cytotoxicity receptors NK cell NK, natural killer NKD, NK cell deficiency PAMPs, Pathogen Associated Molecular Patterns PBMCs, peripheral blood mononuclear cells PRRs, Pattern Recognition Receptors RANTES, Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted RIG, Retinoic acid-inducible gene SARS-CoV-2 SARS-CoV, severe acute respiratory syndrome-coronavirus TGF, Transforming growth factor TLR, Toll-like receptor TNF, Tumor Necrosis Factor Vaccine
[DOI] 10.1016/j.humimm.2021.09.004 PMC 바로가기 [Article Type] Review

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

Article

Published on 2021-07-312023-06-15
Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS,

[키워드] cCD56^bright, Conventional CD56^brightCD16^neg cCD56^dim, Conventional CD56^dimCD16^pos COVID-19 COVID-19, Coronavirus disease 2019 cytotoxicity HLH, Hemophagocytic lymphohistiocytosis Innate immunity NK cells NK, natural killer RNA-seq, RNA sequencing SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 uCD56^dim, Unconventional CD56^dimCD16^neg unconventional CD56^dimCD16^neg (uCD56^dim) NK cell
[DOI] 10.1016/j.jaci.2021.07.022 PMC 바로가기

SARS-CoV-2 Infection in the Immunodeficient Host: Necessary and Dispensable Immune Pathways

Article

Published on 2021-07-152023-07-01
Journal: The journal of allergy and clinical immunology. In [Category] SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 Acquired immunodeficiency ARDS, acute respiratory distress syndrome COVID-19 COVID-19, Coronavirus disease 2019 ICU, Intensive care unit IEI, Inborn errors of immunity IFN-I, type I interferon Immunosuppression inborn errors of immunity MIS-C MIS-C, Multisystemic inflammatory syndrome in children NK, natural killer S protein, spike protein SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TLR, Toll-like receptor
[DOI] 10.1016/j.jaip.2021.06.045 PMC 바로가기

TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2

Article

Published on 2021-06-172023-07-01
Journal: Cellular signalling [Category] SARS,

[키워드] ACE2 ACE2, angiotensin-converting enzyme 2 COVID-19, coronavirus disease 19 IFN-γ receptor IFNGR, Interferon gamma receptor IRFs, IFN-regulatory factors Lung epithelial cells NK cells NK, natural killer SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TMPRSS2, Transmembrane serine protease 2 TRIM, Tripartite motif containing TRIM28 ZNF, Zinc finger protein
[DOI] 10.1016/j.cellsig.2021.110064 PMC 바로가기 [Article Type] Article

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Article

Published on 2021-02-192023-06-16
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

SARS CoV2 infection _The longevity study perspectives

Review

Published on 2021-02-162023-06-16
Journal: Ageing research reviews [Category] MERS, SARS,

[키워드] 5-LO, lipoxygenase 5 ACE, angiotensin-I converting enzyme ACE/DD, polymorphism of the angiotensin converting enzyme ACE2, angiotensin converting enzyme 2 ADAM-17, metallopeptidase domain 17 Ang, angiotensin aPTT, partial thromboplastin time ARDS, acute respiratory distress syndrome AT1R, activity of angiotensin 1 receptors AT2R, activity of angiotensin 2 receptors BMI, body max index CCR5Δ32, genetic variant of chemokine receptor COVID-19 COVID-19, Coronavirus disease 2019 Cox 2, cyclooxygenase 2 CpGIs, CpG islands D, deletion DBP, diastolic blood pressure DCs, dentritic cells DIC, disseminated intravascular coagulation DUSP1, dual specificity phosphatase 1 EC, Endothelial cells EH, essential hypertension ET-1, endothelin-1 FDP, fibrin degradation products FGF21, fibroblast growth factor 21 FluAV, influenza A virus HDACS, histone deacetylases HIV-1, human immunodeficiency virus-1 hPIV2, human parainfluenza virus type 2 HSPs, heat shock proteins I, insertion IFN-γ, interferon-γ INR, international normalized ratio of the prothrombin time IP-10, IFN-γ -Inducible Protein 104 Italian nonagenarians/centenarians Longevity model LPS, lipopolysaccharide MAPK, Mitogen-activated protein kinase MCP1, monocyte chemoattractant protein-1 MI, myocardial infarction MKP-1, mitogen-activated protein kinase phosphatase-1 () Mphi, human macrophages NAD, nicotinamide adenine dinucleotide NF-Kb, nuclear transcription factor kB NK, natural killer NO, Nitric Oxide ORF, open reading frame PAI-1, plasminogen activator inhibitor-1 PC, prostate cancer PCR, polymerase chain reaction PD, protease domain PT, prothrombin time PTMs, post-translational modifications RANTES, regulated upon activation, normal T cell expressed and secreted RAS, renin-angiotensin aldosterone system RBD, receptor-binding domain Researching genetic basis of resistance and potential pharmacological targets RFLP, restriction fragment length polymorphism ROS, reactive oxygen species RSV, respiratory syncytial virus SARS CoV2, severe acute respiratory syndrome Coronavirus 2 virus SARS-1, severe acute respiratory syndrome virus 1 SBP, systolic blood pressure SIRT-1, Sirtuin 1 SNP, single nucleotide polymorphism SSCP, single strand conformation polymorphism ssRNA, single-stranded RNA T2DM, type 2 diabetes mellitus TGF-β, transforming growth factor beta Th1, t-helper lymphocyte type 1 TLR4, Toll-Like Receptor 4 TNF-α, tumor necrosis factor-α TNFR, tumor necrosis factor receptor
[DOI] 10.1016/j.arr.2021.101299 PMC 바로가기 [Article Type] Review

Probiotics: A potential immunomodulator in COVID-19 infection management

Review

Published on 2021-02-132023-06-14
Journal: Nutrition Research (New York, N.y.) [Category] MERS, SARS,