non-human primates – Page 2 – Communicable Diseases Research

Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

Article

Published on 2022-06-072022-10-04
Journal: Nature Communications
[Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법,

SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats

SARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생

Article

Published on 2022-06-012022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathology. pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2
[DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article

Human-to-dog transmission of SARS-CoV-2, Colombia

콜롬비아, SARS-CoV-2의 사람에서 개 전염

Article

Published on 2022-05-122022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] ACE2 protein acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent clade close contact Complete conservation contribute coronavirus 2 COVID-19 pandemic docking E484K E484K mutation events Genome help hosts Human Latin America Lineage Localization molecular analysis Mutation non-human primates Phylogenetic prediction Prevent Protein protein structure public health RBD receptor Receptor-binding domain respiratory SARS-CoV-2 sequenced Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein symptomatic the receptor-binding domain the Spike Transmission transmission of SARS-CoV-2 viral infection viral sequence viral sequences virus
[DOI] 10.1038/s41598-022-11847-9 PMC 바로가기 [Article Type] Article

Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaques

Article

Published on 2022-05-102022-10-05
Journal: Molecular therapy : the journal of the American So
[Category] COVID19(2023년), SARS, 변종, 진단,

SARS-CoV-2 and wastewater: What does it mean for non-human primates?

SARS-CoV-2와 폐수: 인간이 아닌 영장류에게 어떤 의미가 있습니까?

Article

Published on 2022-05-012022-09-11
Journal: American journal of primatology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected approach best changed Contact contracting the virus coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 disease disease transmission Evidence genetic susceptibility global pandemic help Human human pathogen Infection monkeys NHP NHPs non-human primate non-human primates Novel coronavirus novel coronavirus disease occurred one health Outbreaks pandemic Pathogens predict processing PROTECT recent researchers respiratory resulting risk risk of transmission SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread susceptibility susceptible synanthropic primates Transmission transmission of disease unique Viral Viral RNA virus wastewater zoonosis zoonosis. zoos
[DOI] 10.1002/ajp.23340 PMC 바로가기 [Article Type] Article

A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques

캡시드 바이러스 유사 입자 기반 SARS-CoV-2 백신은 높은 수준의 항체를 유도하고 붉은털 원숭이를 보호합니다

Article

Published on 2022-04-052022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody titers binding binding and neutralizing antibodies broad neutralizing antibodies capsid caused clinical testing comparable control group convalescent Corona coronavirus COVID-19 demonstrated disease dose-dependent manner Efficacy Evidence evidence of immunogenicity increase in Level macaque mice Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers no evidence of non-human primate non-human primates non-human primates (NHP) protection Protective reduction in respiratory rhesus macaques SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single vaccination Vaccine vaccine administration vaccine group variants variants of concern variants of concern (VOCs) Viral Viral load Virus-like particle virus-like particles virus-like particles (VLP). VLP VOCs worldwide pandemic
[DOI] 10.3389/fimmu.2022.857440 PMC 바로가기 [Article Type] Article

Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates

Article

Published on 2022-03-312022-10-04
Journal: Nature Communications
[Category] MERS, SARS, 변종, 비임상, 진단,

[키워드] acute respiratory syndrome AS03 B.1.351 benefit Beta boost booster booster dose candidate clinical trials coronavirus cross-neutralization cross-neutralizing antibody cross-protection Delta demonstrated Effectiveness elicit evade FIVE functional antibody response Gamma implication increase Infection macaque mRNA naïve subjects neutralizing antibody Neutralizing antibody response non-human primate non-human primates offer omicron parental Preclinical research Protein vaccines question raise Receptor binding domain reduced responses robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly Spike protein subunit the SARS-CoV-2 the vaccine Vaccine vaccine candidates variant variants viral infection VoC VOCs
[DOI] 10.1038/s41467-022-29219-2 PMC 바로가기 [Article Type] Article

Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models

동물 모델에서 SARS-CoV-2 변이체의 전염성 및 병원성

Review

Published on 2022-03-012022-09-11
Journal: Journal of microbiology (Seoul, Korea)
[Category] SARS, 변종, 유전자 메커니즘,

Experimental Models of COVID-19

COVID-19의 실험 모델

Review

Published on 2022-01-052022-09-11
Journal: Frontiers in Cellular and Infection Microbiology
[Category] SARS, 변종, 진단,

[키워드] in vitro model ACE2 receptor African African green monkeys animal model animal models balancing biosafety level cell line contribute COVID-19 COVID-19 disease different cell different cells Epidemic experimental models of COVID-19 ferret green hamster Hepatitis Human human populations humanized immortalized In-vitro Infection Laboratory level 3 macaques mechanism MHV-1 mice mimicking Model mouse mouse hepatitis murine hepatitis virus NHPs non-human primates pandemic pathology Pneumonia Prevent primate receptor receptors Replication Research rhesus macaques robustness SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Scientific community Spectrum susceptible therapy Transgenic mouse Transmission transmitted treat variants of concern Viral viral infection virus
[DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review

A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

Brief Communication

Published on 2021-12-032022-10-30
Journal: NPJ Vaccines
[Category] COVID-19,

[키워드] alleviate B.1.1.7 B.1.351 B.1.617.2 Beta combating COVID-19 COVID-19 pandemic Delta effective Efficacy Gamma immunization IMPROVE mice neutralization Neutralizing antibody titer non-human primates P.1 Protein vaccines reduced SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant sequence shown South Africa spike vaccination Vaccinations Vaccine variant VoC Wuhan
[DOI] 10.1038/s41541-021-00411-7 PMC 바로가기 [Article Type] Brief Communication