Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett’s oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot내시경 Barrett의 식도 감시를 우선시하기 위한 Cytosponge 바이오마커 패널 사용: 단면 연구에 이어 실제 전향적인 파일럿Multicenter Study Published on 2022-02-012022-09-10 Journal: The Lancet. Oncology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] age alternative Analysis atypia Barrett's oesophagus BEST2 BEST3 Biomarker Biomarkers Biopsy diagnosis Cancer Cancer Research UK cellular clinical clinical factor clinical factors Clinical practice Clinical research clinical risk clinical risk factor Clinical risk factors clinical trials Cohort conducted COVID-19 COVID-19 pandemic cross-sectional cross-sectional study Decision tree defined Demographic variables determined by Diagnosis dysplasia effective Endoscopic biopsy endoscopy evaluate evaluated feasibility finding FIVE funding gold gold standard group groups high risk identify Intervention intestinal intestinal metaplasia laboratory biomarker laboratory biomarkers lead Medical Research Council moderate multicentre network oesophagus overexpression p53 participant Pathways Patient patients patients older Positive predictive value Prague Predictive value Prevalence primary endpoint progression prospective cohort reduction in repeated retrospective risk Sex Surveillance TFF3 the primary endpoint tongue validation cohort [DOI] 10.1016/S1470-2045(21)00667-7 PMC 바로가기 [Article Type] Multicenter Study
Competitive Endogenous RNA Network Activates Host Immune Response in SARS-CoV-2-, panH1N1 (A/California/07/2009)-, and H7N9 (A/Shanghai/1/2013)-Infected Cells경쟁적인 내인성 RNA 네트워크는 SARS-CoV-2-, panH1N1(A/California/07/2009) 및 H7N9(A/Shanghai/1/2013)에 감염된 세포에서 숙주 면역 반응을 활성화합니다Article Published on 2022-01-302022-09-11 Journal: Cells [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 치료기술, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Apoptosis autophagy Avian Influenza binding Cell cellular coronavirus Coronaviruses downregulated gene endogenous expression H1N1 H7N9 Hope host cell host cells in viral indicated infected cells Infection Influenza influenza A influenza A virus influenza A viruses Influenza virus inhibit Interaction involved IRF1 IRF1 mRNA lncRNA metabolic pathways molecular mechanism molecular mechanisms mRNA network noncoding RNA Other outbreak p53 p53 signaling pathway pandemic pathogenicity pathway pertussis provide Regulation Research respiratory respiratory virus response responsible RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2- severe acute respiratory syndrome Coronavirus signaling pathway susceptibility therapeutic agent therapeutic agents these viruses three group three groups Transcriptome Tuberculosis unique upregulated upregulated gene upregulation Viral viral pathogenicity virus viruses [DOI] 10.3390/cells11030487 PMC 바로가기 [Article Type] Article
Identification of potentially anti-COVID-19 active drugs using the connectivity MAP연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인Research Article Published on 2022-01-272022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus [DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?원발성 갑상선 육종에서 SARS-CoV-2 검출: 우연인가 상호작용인가?Case Reports Published on 2022-01-052022-09-10 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] analyzed Chain Reaction COVID-19 epidemic cytology cytopathic cytoplasmic demonstrated diagnosed diffuse downregulation evaluated expression homolog Hypothesis immunological MDM2 mouse neoplastic neoplastic cells overexpression p53 pathway Patient polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved Sarcoma SARS-CoV-2 SARS-CoV-2 detection sequence specimen Spread Subacute thyroiditis synergistic Thyroid thyroid dysfunction Thyroiditis Tumor tumor cell tumor cells tumor growth turn Vero E6 Vero E6 cell VERO E6 cells Viral viral particle Viral particles viral persistence Whole-genome sequence [DOI] 10.1007/s40618-021-01722-1 PMC 바로가기 [Article Type] Case Reports
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
The interferon landscape along the respiratory tract impacts the severity of COVID-19호흡기를 따라 나타나는 인터페론 풍경은 COVID-19의 심각성에 영향을 미칩니다Article Published on 2021-09-162022-09-12 Journal: Cell [Category] Fulltext, MERS, 진단, [키워드] Abstract acute respiratory syndrome age airways anatomical Apoptosis cell death characterized coronavirus coronavirus disease COVID-19 COVID-19 patient critical patient dendritic cell disease disease risk disease severity elevated epithelial cell Express expression IFN IFN-I IFN-III IFN-stimulated genes IFN-λ1 ill patient immune Impact in-depth analysis interferon interferons (IFNs ISG lower airway lung Mild p53 Pathologies pathology pathway Patient pattern recognition receptor Production proliferation PROTECT Protective reduced reduction in respiratory tract reveal SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2-infected patient severe COVID-19 severity severity of COVID-19 subject Transcription type I Type I IFN type III Type III IFN upper airway upper respiratory tract viral burden Viral load [DOI] 10.1016/j.cell.2021.08.016 PMC 바로가기 [Article Type] Article
Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approachCOVID-19 발병 기전에서 예측된 SARS-CoV-2 miRNA의 역할 해독: 생물정보학 접근Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Apoptosis apoptotic pathway apoptotic pathways approach bioinformatics computational tool computational tools Coronavirus-2 COVID-19 COVID-19 pathogenesis dataset deregulated down-regulated down-regulated gene e genes enriched pathways function functional enrichment Genes global pandemic Host immune immune responses immune system infected cells infections influence immune responses involved KEGG pathway analysis microRNA miRNA miRNAs modulating molecular mechanism p53 Pathogenesis pathogenicity pathway predicted progression provide regulated Repository SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 miRNA SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling significantly survival target the SARS-CoV-2 transcriptomic profile up-regulated viral miRNA viral miRNAs viral pathogenesis virus [DOI] 10.1016/j.compbiomed.2021.104669 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus InfectionReview Published on 2021-08-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 addition binding site boost codon codon 72 polymorphism of p53 CRISPR downstream element entry receptor Gene Expression global scientific community host cells Human IFNβ inhibiting Innate innate immune response Innate immunity interferon ISGF3 complex ISRE JAK/STAT signaling pathway mortality rate MOST p53 PARP1 promoter promoter region regulate response restrict role Safe SARS-CoV-2 serine protease TMPRSS2 Signaling Single nucleotide polymorphism (SNP) SNP Stat1 STAT2 target therapy TLRs (toll-like receptors) TMPRSS2 Transcription transcriptional level TSS Type I IFN understanding virus entry virus infection [DOI] 10.3390/ijms22168660 PMC 바로가기 [Article Type] Review
Porcine Epidemic Diarrhea Virus Induces Vero Cell Apoptosis via the p53-PUMA Signaling PathwayArticle Published on 2021-06-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate addition African green monkey Analysis annotation Apoptosis apoptosis pathways BAX/Bcl-2 Blotting differentially expressed gene effective epidemic diarrhea expression flow cytometry Genome Illumina immune in vitro induce Infection Inflammation inhibit inhibitor inoculated KEGG Kyoto MAPK signaling mechanism p53 p53 signaling pathway pathogenic pathway Pathway enrichment analysis PEDV Porcine epidemic diarrhea virus promote Proteins puma qRT-PCR Randomly reported screened selected Sequencing shown signaling pathway significantly significantly increased Support target gene TNF signaling total RNA transcriptome sequencing Vaccine Vero Vero Cell was performed [DOI] 10.3390/v13071218 PMC 바로가기 [Article Type] Article
He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic StudyPharmacology Published on 2021-06-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan [DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology