Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling ApproachesArticle Published on 2021-03-042022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acetoside active against addition Anti-SARS-CoV-2 Activity antiviral medicine apigenin-7-O-glucoside approach assessment carried Compound Concentration coronavirus Coronavirus infections COVID-19 enzyme explain Free identify in vitro increase in inhibitors of SARS-CoV-2 isolate ligands modeling moderate naringenin natural overcome pandemic patients worldwide pharmacophore positive control product protease repurposing SARS-CoV-2 SARS-CoV-2 Egyptian strain SARS-CoV-2 main protease selected sennoside sennoside B Spread tested the SARS-CoV-2 Viral protein Virtual screening Zinc [DOI] 10.3390/ph14030213 PMC 바로가기 [Article Type] Article
A novel rationale for targeting FXI: Insights from the hemostatic microRNA targetome for emerging anticoagulant strategiesReview article Published on 2021-02-012022-10-05 Journal: Pharmacology & therapeutics [Category] 비임상, [키워드] activities antagonist Anticoagulant applicability approaches bleeding Blood coagulation Cardiovascular disorders changed coagulation factor Comorbidity components DOACs Efficacy and safety expression Factor functional Hemostasis IIa Inflammation insight interfere microRNA mimicking oral anticoagulant overcome patients worldwide replaced RNA therapeutics therapeutic therapeutic option Therapeutic strategies therapeutic targeting Thromboembolism thrombosis Traditional Treatment Venous Thromboembolism without affecting [DOI] 10.1016/j.pharmthera.2020.107676 [Article Type] Review article
Altered high-density lipoprotein composition and functions during severe COVID-19심각한 COVID-19 동안 변경된 고밀도 지단백질 구성 및 기능Article Published on 2021-01-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Admission affecting Alpha Altered amyloid A Analysis Anti-inflammatory antioxidant antitrypsin Apolipoprotein Apoptosis Biomarkers cadherin changes in conditions consequence controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Day Decreased Endothelial cell endothelial cells exposure to function HDL HDL-C HDLs healthy subjects high-density initial intensive care intensive care unit less lipid metabolism mass spectrometry pandemic Particle Patient patients worldwide permeability plasma Protective Protein proteome Proteomic analysis proteomics pulmonary damage reported SARS-CoV-2 serum amyloid severe COVID-19 severe COVID-19 patient severe COVID-19 patients Sex TNFα VE-cadherin viral infection was performed [DOI] 10.1038/s41598-021-81638-1 PMC 바로가기 [Article Type] Article
Cutaneous manifestations in patients with coronavirus disease 2019: clinical and histological findings2019년 코로나바이러스 질환 환자의 피부 발현: 임상 및 조직학적 소견Article Published on 2021-01-012022-09-11 Journal: Human pathology [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody appear biopsy caused characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutaneous cutaneous manifestation Cutaneous manifestations dermatitis dermatopathology dermis described descriptions detectable detection differential diagnosis feature flu-like symptoms histological histopathological histopathological feature Hospitalized hypersensitivity reaction Immunochemistry immunohistochemistry immunostaining In situ hybridation In situ hybridization Inflammatory Initially interface dermatitis manifestation Mild nucleocapsid protein pathology Patient patients worldwide performed perivascular polyclonal presenting Protein Rash rashes reported respiratory retrieved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient severe acute respiratory syndrome Coronavirus skin skin biopsies skin biopsy skin lesions spongiosis university university hospital Viral Viral RNA virus [DOI] 10.1016/j.humpath.2020.10.011 PMC 바로가기 [Article Type] Article
In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients심층 혈액 프로테옴 프로파일링 분석은 중증 코로나19 환자와 그렇지 않은 COVID-19 환자 사이에서 혈장 단백질의 뚜렷한 기능적 특성을 밝혀냈습니다.Article Published on 2020-12-292022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Biomarker Blood Candidates Characteristics Clinical outcome complement Complement activation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases develop differentially expressed disease severity downstream eight Factor functional highlighting host response IMPROVE Infectious diseases interleukin interleukin-6 mortality rate Necrosis neutrophil neutrophil activation Patient patients worldwide performed plasma plasma protein Platelet potential therapeutic target potential therapeutic targets predict profiling analysis Prognosis prognostic biomarker Prognostic markers proinflammatory Protein Proteins proteome proteomic Proteomic analysis proteomics quantified reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity of COVID-19 Support T cell Tumor tumor necrosis tumor necrosis factor upstream [DOI] 10.1038/s41598-020-80120-8 PMC 바로가기 [Article Type] Article
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main proteaseResearch Article Published on 2020-12-032022-10-04 Journal: Heliyon [Category] 신약개발, [키워드] Anti-SARS-CoV-2 Activity ARB ARBs Azilsartan binding affinity binding free energy Biological Biological sciences blocker Blood coagulation carried Chemistry clinical study Combination Compound compounds computer Computer science COVID-19 COVID-19 pandemic COVID-19 virus disease docked docking drug Drug repurposing drugs targeting effective drug Effectiveness eprosartan fibrosis in vitro In vitro studies Inflammation inhibit Irbesartan material Materials science MD MM-GBSA molecular N3 inhibitor nine olmesartan pandemic coronavirus Patient patients worldwide Physics Prevent profiles Prophylactic protease pulmonary fibrosis receptor reduce required SAR SARS-CoV-2 SARS-CoV-2 protease Science telmisartan tested Treatment valsartan vasodilatation VERO E6 cells Virtual screening was performed [DOI] 10.1016/j.heliyon.2020.e05641 PMC 바로가기 [Article Type] Research Article
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2SARS-CoV-2의 재발성 돌연변이로 인한 전염성 증가에 대한 증거 없음Article Published on 2020-11-252022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation allele animal reservoir association caused circulation clade coronavirus coronavirus SARS-CoV-2 COVID-19 curated dataset descendant descendants develop Evidence Genome informatics homoplasies homoplasy human host Human immune system human population humans identify Lineage Mutation mutations natural selection Neutral patients worldwide Phylogenetic phylogenetics recurrent mutation RNA SARS-CoV-2 SARS-CoV-2 genome significantly significantly more Transmissibility Viral Viral genetics Viral transmission [DOI] 10.1038/s41467-020-19818-2 PMC 바로가기 [Article Type] Article
Incidence and pathophysiologic mechanisms of stroke in the COVID-19 pandemic: the dilemmaReviews Published on 2020-09-292022-10-31 Journal: The Egyptian Journal of Bronchology [Category] COVID-19, [키워드] affected Care COVID-19 COVID-19 pandemic critical condition Impact implicated IMPROVE incidence management mechanism outcomes pandemic pathophysiologic pathophysiology Patient patients with COVID-19 patients worldwide stroke while [DOI] 10.1186/s43168-020-00033-y PMC 바로가기 [Article Type] Reviews
The Wide Spectrum of COVID-19 Clinical Presentation in ChildrenArticle Published on 2020-09-122022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abdominal pain acute respiratory distress syndrome acute rhinitis Adults age Cell Chest children clinical Cohort cough COVID-19 COVID-19 severity diagnosed disease Dyspnea Evolution explain fatigue Fever form France help Hospitalization Hospitalized hypothese ICU treatment Infants Infection median age MIS-C myocarditis Nasopharyngeal swab obesity outcomes overweight Paris Patient patients patients worldwide pediatric PIMS-TS positive positive RT-PCR presentation raised reported required SARS-CoV-2 SARS-CoV-2 RT-PCR School Spectrum Symptom syndrome tomography Transmission virus with COVID-19 [DOI] 10.3390/jcm9092950 PMC 바로가기 [Article Type] Article
COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmissionReview Published on 2020-08-272022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] Asymptomatic Asymptomatic case asymptomatic individual asymptomatic infection asymptomatic patient China Clinical course Clinicians confirmed case early treatment effort epidemiologists Evidence expected global public health Hospitalization Infection information insight Isolation joint majority management Patient patients patients worldwide physical Population proportion provided raised SARS-CoV-2 serological assays severity social distancing suggested Symptom Transmission transmitted virus [DOI] 10.7150/ijbs.48991 PMC 바로가기 [Article Type] Review