ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19지방 조직에서의 ACE2 발현은 코로나19에 대한 심장 대사 위험 인자 및 세포 유형 구성과 관련이 있습니다.Meta-Analysis Published on 2022-08-012022-09-11 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression adipose Adipose tissue age angiotensin angiotensin I angiotensin I converting enzyme 2 BMI Cell cell type cell types cellular entry contribute COVID-19 COVID-19 severity diabetes Diseases distal Endothelial cell enzyme eQTLs expression Factor Factors fasting insulin feature Genetic HDL Health identify increased risk independent individual insulin investigated loci Lower lower expression Macrophage macrophages Meta-analysis obesity participant pathophysiology phenotypic proportion proximal Quantitative receptor risk risk factor RNA-Seq SARS-CoV-2 serum severe COVID-19 T2D tissue tissue expression type 2 diabete type 2 diabetes [DOI] 10.1038/s41366-022-01136-w PMC 바로가기 [Article Type] Meta-Analysis
Evaluation of Metagenomic and Targeted Next-Generation Sequencing Workflows for Detection of Respiratory Pathogens from Bronchoalveolar Lavage Fluid Specimens기관지폐포 세척액 표본에서 호흡기 병원체 검출을 위한 메타게놈 및 표적 차세대 시퀀싱 워크플로 평가Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antimicrobial resistance applied approach approaches automated Bacteria BAL bioinformatic analysis Bronchoalveolar lavage carbapenem complementary complex coronavirus cytomegalovirus defined demonstrated detection diagnostics ENhance evaluated house Illumina in some Inc. lavage less Lower respiratory tract lower respiratory tract infection marker metagenomic Next-generation sequencing NGS nonpathogenic Organisms pathogen Pathogens phenotypic positive Pseudomonas aeruginosa reagent reagents replacement required respiratory Respiratory pathogens respiratory tract infection rhinovirus sequence Sequencing severe acute respiratory syndrome Coronavirus specimen standardized criteria Ureaplasma [DOI] 10.1128/jcm.00526-22 PMC 바로가기 [Article Type] Article
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection바이러스 감염에 의해 유도된 비정상적인 복제 허용 전사 프로그램의 네트워크 기반 식별 및 약리학적 표적화 모델Article Published on 2022-07-192022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activate Analysis Cell cell viability determinant drug drugs targeting effective epithelial cell epithelial cells functional gene expression signature Host host cell identify inactivation induce infected cell infected cells Interaction mechanism of action methodology pathogen pharmacological phenotypic physical predicted Protein reduction regulator Replication representing repressed SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 replication therapy transcriptional treated viability viral infection virus replication without affecting [DOI] 10.1038/s42003-022-03663-8 PMC 바로가기 [Article Type] Article
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort대규모 용도 변경 노력에서 VERO-E6 세포에 대한 세포변성 SARS-CoV-2 스크리닝Article Published on 2022-07-132022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate anti-inflammatory drug approach Cell Compound COVID-19 COVID-19 disease Dexamethasone Drug discovery drugs effective effort greater highlighting idea identify inhibitor Intensive mechanism Patient patients phenotypic phenotypic screening potential therapies potential therapy reducing mortality Remdesivir repertoire Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection screened shown Support Time to recovery viral infection [DOI] 10.1038/s41597-022-01532-x PMC 바로가기 [Article Type] Article
The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variantsSARS-CoV-2 변종에 의해 형성되는 돌발성 감염 후 면역 회수의 규모와 시기Article Published on 2022-07-122022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation antibody Antibody titers B cell B cell immunity B cells Breakthrough infection breakthrough infections CD4 CD4 T cell immunity CD8 CD8 T cell immunity cellular immunity Clinical outcome clinical outcomes COVID-19 COVID-19 vaccines Delta humoral immune Immunity Immunological memory IMPROVE increase in infecting Infection lack magnitude Neutralizing Neutralizing antibodies neutralizing antibody titers omicron phenotypic potential mechanism PROTECT protective effect Protective effects provide recall recalled response robust SARS-CoV-2 SARS-CoV-2 variant seropositive individual seropositive individuals severe COVID-19 T cell the timing vaccinated individuals vaccination variant Viral viral clearance viral replication while [DOI] 10.1016/j.immuni.2022.05.018 PMC 바로가기 [Article Type] Article
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone [DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine StimulationDiscovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.Article Published on 2022-07-012022-09-11 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon [DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
Epidemiological and virological surveillance of influenza viruses in China during 2020-20212020-2021년 동안 중국에서 인플루엔자 바이러스의 역학 및 바이러스 감시Article Published on 2022-06-292022-09-11 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyses Analysis analyzed antigenic antigenic diversity Antiviral antiviral medication Antiviral medications B/Victoria lineage viruses caused Characteristics characterized China Chinese circulating collected component components conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic declined Diversity Epidemic epidemiological Epidemiology flu Genetic genetic diversity Hemisphere hospital Influenza influenza like illness Influenza virus influenza viruses inhibitors isolate Laboratory Lineage mainland molecular Mutation network neuraminidase inhibitor neuraminidase inhibitors Next-generation sequencing outbreak pandemic phenotypic Phylogenetic analysis preventive measure preventive measures reduced Region remained representing respiratory respiratory specimens respond SARS-CoV-2 Seasonal influenza sensitivity Sequencing severe acute respiratory syndrome Coronavirus specimen study period Surveillance susceptibility tested the vaccine unique Virological Virological. virus viruses was performed was used Winter [DOI] 10.1186/s40249-022-01002-x PMC 바로가기 [Article Type] Article
Meaningful Use of Pathogen Genomic Data병원체 게놈 데이터의 의미 있는 사용Comment Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis bioinformatics Characteristics collected contributing to epidemiological Factor failure genomic Genomic analysis genomic data genomic databases Genomic epidemiology Gill Health Hedge implication instances limitations lineages mBio methicillin methicillin-resistant Staphylococcus aureus MRSA pathogen Pathogens phenotypic Population population genomics powerful tool SARS-CoV-2 Staphylococcus Staphylococcus aureus term These data utility Wilson [DOI] 10.1128/mbio.00311-22 PMC 바로가기 [Article Type] Comment
Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen16주 간격 BNT162b2 요법에서 강력한 백신 반응성과 B 및 T 세포 면역의 시간적 연관성Article Published on 2022-06-282022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Administered AIM assay Analysis association associations B cell B cell response B cells BNT162b2 BNT162b2 mRNA CD4 CD4 T cell CD4 T cell help CD8 CD8 T cell cellular Clustering cohorts coronavirus COVID-19 CP: Immunology donors dose Efficacy elicit feature first dose functional humoral Humoral response humoral responses immune immune memory Immunity immunological Immunological memory longer interval magnitude memory T mRNA mRNA vaccine of BNT162b2 participant phenotypic raise recall regimen response reveal robust SARS-CoV-2 second dose single-cell spacing spike spike glycoproteins T cell T cell response T helper Temporal Vaccine vaccine regimen. while [DOI] 10.1016/j.celrep.2022.111013 PMC 바로가기 [Article Type] Article