PI3K – Page 2 – Communicable Diseases Research

Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations

신경학적 징후가 있는 COVID-19 환자의 뇌척수액의 차세대 시퀀싱 및 단백질체학

Immunology

Published on 2021-12-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] Ageusia alterations Analysis Anosmia Case series case sery cellular cerebrospinal fluid changes in CNS complement complement system conducted Control COVID-19 COVID-19 confirmed patients COVID-19 patient CSF detection rate Diagnosis differentially expressed difficulty feature headache Infection Interaction Macrophage macrophages manifestation neurological Neurological involvement neurological manifestation neurological manifestations Next-generation sequencing NGS non-COVID-19 patient outbreak patch Pathogenesis pathological mechanism pathway Patient patients PI3K PI3K-Akt signaling Protein proteomic Proteomic analysis proteomics reported SARS-CoV-2 SARS-CoV-2 RNA screened selected Sequencing serum sample serum samples variant
[DOI] 10.3389/fimmu.2021.782731 PMC 바로가기 [Article Type] Immunology

miRNA-223 as a regulator of inflammation and NLRP3 inflammasome, the main fragments in the puzzle of immunopathogenesis of different inflammatory diseases and COVID-19

염증 조절제로서의 miRNA-223 및 다양한 염증성 질환 및 COVID-19의 면역 병인 발생 퍼즐의 주요 단편인 NLRP3 인플라마좀

Review

Published on 2021-11-012022-09-11
Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute lung injury acute respiratory distress syndrome antioxidant antiviral role caspase caspase-1 CCL3 Control COVID-19 CXCL2 distress Factors feature FOXO1 genomic sequence HDAC2 IFN-I IKKα IL-18 IL-1β IL-6 Immunopathogenesis implicated infection with SARS-CoV-2 Inflammation inflammatory disease inflammatory process involved ITGB3 lung Lung injury mechanism miR-223 miR-223. miRNA monocyte-macrophage neutrophil neutrophil recruitment NF-κB NLRP3 NLRP3 inflammasome PARP PI3K pro-inflammatory responses Regulatory remained respiratory distress Respiratory distress syndrome SARS-CoV-2 STMN1 TLR4 Traf6 variety with COVID-19
[DOI] 10.1007/s00210-021-02163-6 PMC 바로가기 [Article Type] Review

Diabetes and susceptibility to infections: Implication for COVID-19

당뇨병과 감염에 대한 감수성: COVID-19에 대한 시사점

Review

Published on 2021-11-012022-09-11
Journal: Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] activating binding Cell cell survival contribute COVID-19 COVID-19 infections diabete diabetes Diabetic differentiation dysregulated explain Factor healthcare immune immune activation Immune cell immune cells immune checkpoint blocker immune response immune-related genes in viral Infection infections Inflammation insulin insulin receptor insulin resistance involved lymphocyte Lymphocytes mechanism mTOR myeloid cell myeloid cells nucleus observation outcome pathology pathway Pathways peripheral tolerance PI3K polarization Proteins receptor regulate shown survival susceptibility susceptibility to infection the strongest Transcription translocate Viral viral infections
[DOI] 10.1111/imm.13383 PMC 바로가기 [Article Type] Review

Association of Antineoplastic Therapy With Decreased SARS-CoV-2 Infection Rates in Patients With Cancer

암 환자의 SARS-CoV-2 감염률 감소와 항종양 요법의 연관성

Article

Published on 2021-11-012022-09-11
Journal: JAMA Oncology [Category] Fulltext, MERS, 치료제,

[키워드] 95% CI ACE2 ACE2 gene active treatment additional sensitivity analyses additional sensitivity analysis age Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antineoplastic antineoplastics association Cancer cancer type cancers cell lines cellular center Cohort cohort study Compound compounds confounders COVID-19 pandemic database Decreased determine disrupt downregulation drug treatment evaluated exhibited expression female finding gemcitabine gene expression signature identify in silico analysis inhibitor library male measure Memorial mTOR multivariable analysis New York novel Odds ratio outcome Patient patients Patients with cancer PI3K positive Rate receiving reduced Replication retrospective cohort SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test signature significantly lower statistically steroid steroid use therapy these compound these compounds treated Treatment
[DOI] 10.1001/jamaoncol.2021.3585 PMC 바로가기 [Article Type] Article

Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation

Research Article

Published on 2021-10-202023-06-13
Journal: The Journal of Biological Chemistry [Category] MERS,

Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C

가와사키병 및 MIS-C 환자에서 정맥 면역글로불린에 대한 면역 반응

Article

Published on 2021-10-152022-09-12
Journal: The Journal of Clinical Investigation [Category] MERS, 진단,

Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking Technology

Research Article

Published on 2021-10-112022-10-31
Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19,

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients

Review

Published on 2021-09-232023-07-02
Journal: Immunology letters [Category] SARS,

[키워드] AKT COVID-19 immune modulation mTOR PI3K thrombosis
[DOI] 10.1016/j.imlet.2021.09.005 PMC 바로가기 [Article Type] Review

PI3K in T Cell Adhesion and Trafficking

Review

Published on 2021-08-062023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] adhesion CCR7 CD62L integrin LFA-1 PI3K Trafficking
[DOI] 10.3389/fimmu.2021.708908 PMC 바로가기 [Article Type] Review

Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy

과립구 대식세포 집락 자극 인자가 도래했다: 백신 보조제에서 항바이러스 면역요법까지

Review

Published on 2021-06-012022-09-11
Journal: Cytokine & growth factor reviews [Category] SARS, 치료제,