Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccinationJanus kinase inhibitor로 치료받은 류마티스 관절염 환자, BNT162b2 백신 접종 후 체액성 면역 반응 감소Article Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] Activation alteration analysed anti-spike antibodies anti-Spike IgG Anti-spike IgG antibody antibodies antibody antibody titres Arthritis B cell B cell responses B cells B-lymphocytes BNT162b2 BNT162b2 vaccine collected COVID-19 COVID-19 vaccine determine dose Efficacy elicited ELISA expression germinal centre healthy individual healthy individuals humoral humoral immune response Humoral immunity IgA antibody individuals JAK inhibitor Janus kinase Janus kinase inhibitor Janus kinase inhibitors less mRNA-based COVID-19 vaccine neutralization activity Neutralization assay neutralization capacity Patient patients patients treated plasma plasma sample quantitative PCR reduced Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-COV-2 infection shown Spike protein suppressed the SARS-CoV-2 the vaccine titre treated vaccination Vaccine Vaccines Virus neutralization was reduced was used [DOI] 10.1093/rheumatology/keab879 PMC 바로가기 [Article Type] Article
Simulated RBC antibody identification training panels created using SARS-CoV-2 kodecytes and immune plasmaSARS-CoV-2 kodecytes 및 면역 혈장을 사용하여 만든 시뮬레이션된 RBC 항체 식별 교육 패널Article Published on 2022-08-012022-09-12 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accuracy antibody antibody screening autoantibody can be used Cell competent develop Donor evaluated feasibility Frequency gel IgG IgG antibody immune Kodecyte maintain manual peptide plasma plasma sample platform positive Practical training Precision profile RBC Reactions required SARS-CoV-2 SARS-CoV-2 antibodies technology tested training unmodified cell warm [DOI] 10.1111/trf.17004 PMC 바로가기 [Article Type] Article
IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19중증 COVID-19 환자의 임상 결과에서 IFNAR2 관련성Article Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] 변종, 치료제, [키워드] amplify Antiviral antiviral response assays association beta receptor Clinical outcome COVID-19 COVID-19 mortality cytokine Cytokines determined by ELISA evaluate Genetic genetic susceptibility Genetic variant genetic variants Hospitalized IFN IFNAR1 IFNAR2 IFNs immunomodulatory activities individual individuals Innate immunity interferon Interferon alpha interferon alpha-beta interferons investigated Mortality mortality risk Non-survivors Patient patients hospitalized plasma sample plasma samples Protein receptor receptors severe COVID-19 severity SNP subject subunit survivor the disease Type type I IFNs variant with COVID-19 [DOI] 10.3389/fimmu.2022.949413 PMC 바로가기 [Article Type] Article
Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링Article Published on 2022-07-212022-09-11 Journal: Cardiovascular Diabetology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19 [DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article
Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening [DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article
The relationship between hydroxychloroquine plasma concentration and COVID-19 outcomes in rheumatoid arthritis patients in Saudi ArabiaResearch article Published on 2022-07-012022-10-05 Journal: Saudi Pharmaceutical Journal : SPJ [Category] 신약개발, 치료제, [키워드] accounted Alter collected complications Concentration confirmed case COVID-19 COVID-19 complications COVID-19 incidence COVID-19 symptom daily dose determine dose dry cough enrolled fatigue Fever HCQ headache Hospitalization Hydroxychloroquine incidence of COVID-19 indicated individual infected patient intensity loss of taste Mild moderate no correlation occurrence of COVID-19 outcome Patient patients per day plasma concentration plasma sample ranged receiving Result rheumatoid arthritis Saudi Arabia Symptom treat Treatment [DOI] 10.1016/j.jsps.2022.05.006 [Article Type] Research article
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination감염 또는 예방 접종 후 재태 연령이 일치하는 모자에서 SARS-CoV-2 변이체에 대한 중화 항체 활성Article Published on 2022-06-222022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adaptive immunity age analyzed antibody COVID-19 Delta disease during pregnancy effective elicit first trimester gestation gestational age immune response immune responses immunoglobulins individuals Infection Infectious disease less mother mRNA vaccine mRNA vaccines NAb NAbs neutralization neutralization activity Neutralizing plasma plasma sample Pregnancy pregnant Protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 variant second trimester sequence Spike protein spike variants time of delivery transfer unique vaccination Vaccine variant virion was measured with infection women WT spike [DOI] 10.1172/jci.insight.157354 PMC 바로가기 [Article Type] Article
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study단일 조혈모세포 이식 센터에서 COVID-19 감시를 위한 타액, 바이러스혈증 및 혈청 유병률에 대한 SARS-CoV-2: 전향적 코호트 연구Article Published on 2022-06-062022-09-11 Journal: Revista do Instituto de Medicina Tropical de São [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition adopted allogeneic HSCT anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Asymptomatic Brazil COVID-19 dentist dentists FIVE healthcare healthcare worker Healthcare workers Hematopoietic stem cell HSCT Nurse Nurses pandemic Patient plasma plasma sample plasma samples positive positive RT-PCR positive serology Prevalence prospective cohort study protocol Result Saliva sample collection SARS-CoV-2 Seroconversion Seroprevalence Seven stem cell Stem cell transplantation Surveillance tested Two patient two patients Viral Viral detection viral shedding Viremia was performed [DOI] 10.1590/S1678-9946202264039 PMC 바로가기 [Article Type] Article
Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination자연 감염 후 SARS-CoV-2에 대한 자연 살해 세포 매개 항체 의존성 세포 세포 독성은 백신 접종 후보다 더 강력합니다Article Published on 2022-05-162022-09-12 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ADCC Affect Against antibody antibody-dependent cellular cytotoxicity Concentration coronavirus coronavirus disease COVID-19 elicited individuals induce mRNA vaccine natural natural infection natural killer NK cell Patient plasma antibody plasma sample potent recovered patients SARS-CoV-2 significantly Spike-specific antibody vaccinated individuals vaccination [DOI] 10.1093/infdis/jiac060 PMC 바로가기 [Article Type] Article