Binding of raloxifene to human complement fragment 5a ( h C5a): a perspective on cytokine storm and COVID19Article Published on 2022-02-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] approach binding binding affinity C5a C5aR Carprofen Circular dichroism combination therapy complement conformational COVID19 cytokine Cytokine storm Diseases downstream expressed FDA-approved drugs glycoprotein Human Infection Inflammatory diseases inherent management molecular molecular dynamics Neutralizing Pathogenesis Perspective plasticity pleiotropic Polypharmacology precursor pro-inflammatory raloxifene. receptor Stress Support synergistic targets tissues triggering undergo [DOI] 10.1080/07391102.2020.1820381 PMC 바로가기 [Article Type] Article
Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals피토멜라토닌: COVID-19에 노출된 개인에 대한 잠재적 식물 치료 개입Review Published on 2022-02-012022-09-11 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 치료기술, [키워드] acting advancement Anti-inflammatory antioxidant antioxidant effects biological processe blood-brain barrier body temperature Cancer Cell content convenience COVID-19 COVID-19-exposed individuals cross Enzymes extraction free radical immunological individual individuals Intervention involved mitochondrial mood swings pathway physiological Phytomelatonin Phytotherapeutic. plant Plant hormone pleiotropic pro-inflammatory signaling radical scavenger reducing Regulation respiratory infections safety profile Sleep suggested swings therapeutic potential up-regulating [DOI] 10.1016/j.micinf.2021.104886 PMC 바로가기 [Article Type] Review
Galectin-1 as the new player in staging and prognosis of COVID-19갈렉틴-1, COVID-19의 병기 및 예후의 새로운 선수Clinical Trial Published on 2022-01-242022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료기술, [키워드] Analysis Atypical Atypical pneumonia chest radiographic clinical parameter Clinical parameters Corona coronavirus correlated correlation correlations COVID-19 COVID-19 patient COVID-19 progression COVID-19 severity Critical cross-sectional cross-sectional study cytokine Cytokine storm Cytokines death determine disease disease severity Diseases dry cough ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay galectin-1 headache IL-10 IL-1β IL-23 IL-33 IL-6 IL6 immune immunology Inflammatory involved Linear regression model marker mechanism Mild new virus no significant difference no significant differences pleiotropic Pneumonia positive correlation positively correlated Prognosis Proinflammatory cytokine proinflammatory cytokines Regression model released respiratory ROC Curve SARS-CoV-2 serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly higher Stage stage I stage III stimulate systemic the cytokine storm tissue Virus Disease were measured [DOI] 10.1038/s41598-021-04602-z PMC 바로가기 [Article Type] Clinical Trial
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)Article Published on 2022-01-112022-10-04 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상, [키워드] Abstract administration Anti-inflammatory approach ARDS blockade challenge chemokine Clinical data clinical trial combination therapy Concentration coronavirus disease-2019 COVID-19 Cytokine storm Cytokines dosage downstream drugs dysregulated immune response Efficacy explained Future Health hepatic injury highest Hyperinflammatory IL-6 IL-6 inhibitor IL-6 pathway IL-6 signaling IMPROVE interleukin-6 Jak-STAT Janus-kinase inhibitor lung damage membrane monotherapy non-specific Pathways pleiotropic pro-inflammatory progression pulmonary damage recent receptor reduce risk sarilumab severe coronavirus disease severe COVID-19 Side effect Signaling therapeutic approaches Tocilizumab Treatment [DOI] 10.1016/j.intimp.2022.108536 PMC 바로가기 [Article Type] Article
Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applicationsSARS-CoV-2 유발 질환의 인터루킨-6: 상호작용 및 치료적 적용Review Published on 2022-01-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Angiogenesis anti-inflammatory activity blockade C-reactive protein C-reactive protein (CRP C-reactive protein (CRP) Cancer cancer patient chronic inflammation Complete complex Concentration coronavirus cytokine Cytokine storm determine disease effective event hyperinflammation Hypoxemia hypoxia IL-6 IL-6 inhibition IL-6 levels increase Inflammation Interaction Interleukin-6 (IL-6) lymphopenia multi-organ failure Patient patient with SARS-CoV-2 patients with SARS-CoV-2 pleiotropic Pneumonia promote representing SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulatory Taking targeted therapy the SARS-CoV-2 therapeutic therapy Tocilizumab [DOI] 10.1016/j.biopha.2021.112419 PMC 바로가기 [Article Type] Review
Five reasons COVID-19 is less severe in younger age-groupsCommentary Published on 2021-12-262022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] antagonistic antagonistic pleiotropy cause Community COVID-19 crowd diseases explained immune system infection with SARS-CoV-2 less life history life history theory Older pleiotropic progression respond SARS-CoV-2 severity of COVID-19 T cells the timing [DOI] 10.1093/emph/eoaa050 PMC 바로가기 [Article Type] Commentary
Leptin in the Respiratory Tract: Is There a Role in SARS-CoV-2 Infection?Physiology Published on 2021-12-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Affect bidirectional coronavirus coronavirus disease COVID-19 Evidence expressed functions gut microbiota Health immune immune system Immunity interfere involved Leptin Long lung metabolism microbiota modulating obesity organs pathophysiology peripheral tissue pleiotropic protective immunity pulmonary infections receptor respiratory respiratory tract role SARS-CoV-2 SARS-CoV2 susceptibility the gut-lung axis tissue homeostasis [DOI] 10.3389/fphys.2021.776963 PMC 바로가기 [Article Type] Physiology
Plasma Leptin Is Increased in Intensive Care Patients with COVID-19—An Investigation Performed in the PronMed-CohortArticle Published on 2021-12-212022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adipocyte adipocytes Admission analyzed Care conditions contribute correlated COVID-19 COVID-19 pandemic Critical illness cytokine disease disorders expressed female healthy blood donors healthy control hospital ICU Increased intensive care unit investigation IQR Leptin males median men Patient patients with COVID-19 plasma pleiotropic positive PCR Proinflammatory cytokine Prophylaxis risk SAPS3 SARS-CoV-2 severe COVID-19 significantly higher Treatment Uppsala University use of corticosteroids Vaccines [DOI] 10.3390/biomedicines10010004 PMC 바로가기 [Article Type] Article
Niclosamide for Covid-19: bridging the gapCovid-19용 니클로사미드: 격차 해소Review Published on 2021-12-012022-09-11 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme anthelminthic Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Antiviral antiviral activities Antiviral effect antiviral effects biological processes clinical outcomes clinical study clinical trial clinical trials Concentration concerning COVID-19 COVID-19 severity Cytokines Cytopathic effect Direct disease distress Effect endosomal pH enzyme Google Scholar homeostasis immune in vivo Inflammasome inflammatory signaling inhibit interruption mandatory maturation mechanism modulate modulating mTOR mTOR signaling NCL neutralization NF-κB niclosamide NLRP3 NLRP3 inflammasome oral bioavailability oxidative phosphorylation pandemic pathway Patient pleiotropic pro-inflammatory cytokines Prospective protective role reduce reducing Regulatory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection Science Science Direct serum severity signaling pathway suppression therapeutic therapy treat viral proliferation Viral protein was done Web of Science [DOI] 10.1007/s11033-021-06770-7 PMC 바로가기 [Article Type] Review
Use of novel antithrombotic agents for COVID-19: Systematic summary of ongoing randomized controlled trialsCOVID-19에 대한 새로운 항혈전제의 사용: 진행중인 무작위 대조 시험의 체계적인 요약Article Published on 2021-12-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 임상, 치료제, [키워드] acting Activation affecting Anti-inflammatory Antithrombotic Antiviral antiviral effects benefit clinical coagulation cascade Coagulopathy Conventional coronavirus disease Coronavirus disease 2019 COVID-19 defibrotide drug Effect endothelial Endothelial cell fibrosis Health Organization help identify IMPROVE include Inflammatory response macro management mechanism nafamostat Oxygenation Patient Patient management patients with COVID-19 pleiotropic potential mechanism Randomized controlled trial Randomized controlled trials RCT RCTs reduce registry Result searched systematic literature search Trial triggered utility Viral load World Health Organization [DOI] 10.1111/jth.15533 PMC 바로가기 [Article Type] Article