Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19Proteome wide Mendelian Randomization은 혈액 단백질과 심한 covid-19 사이의 인과 관계를 식별합니다Research Article Published on 2022-03-032022-09-10 Journal: PLoS Genetics [Category] MERS, SARS, 바이오마커, 진단, [키워드] ABO applied assumption ATP2A3 binding Biology Biomarker Blood Blood Group Blood level blood levels blood protein blood proteins C1GALT1C1 causal link CD207 Cell contrary COVID-19 COVID-19 pandemic death decrease died disease pathology enzyme FAAH2 facilitate FIVE form forms GCNT4 genetic instrument genetic instruments Hospitalization ICAM-1 identify implicated increased risk individuals investigated involved KEL LCTL lead marker mendelian randomization multiple testing outcome pathophysiology Potential biomarker potential biomarkers Protein RAB14 replicate Research respiratory Respiratory Support risk SELE SELL severe COVID-19 severe forms of COVID-19 severity SFTPD surpassed target targets vaccination Vaccinations with COVID-19 [DOI] 10.1371/journal.pgen.1010042 PMC 바로가기 [Article Type] Research Article
Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implicationsCOVID-19에 대한 내피 기여: 메커니즘 및 치료적 의미에 대한 업데이트Review Published on 2022-03-012022-09-11 Journal: Journal of molecular and cellular cardiology [Category] SARS, 바이오마커, 비임상, 임상, [키워드] addition breath cell entry Clinical characteristics clinical trial clinical trials Coagulopathy COVID-19 disease severity disorders dysfunction elevated endothelial Endothelial dysfunction endothelial injury Endotheliitis immune Immunity implication Inflammation inhibit lung Lungs manifested mechanism organ pathological mechanism pathway Patient Potential biomarker potential biomarkers Prevent public health emergency SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity the disease therapeutic thrombosis Vascular virus [DOI] 10.1016/j.yjmcc.2021.11.010 PMC 바로가기 [Article Type] Review
Metabolomics study of COVID-19 patients in four different clinical stages4 가지 임상 단계에서 Covid-19 환자의 대사체 연구Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] (COronaVIrus Disease 2019) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Analysis Asymptomatic disease bile acid bile acids biological pathway Biomarker Biomarkers change Clinical outcome Clinical stage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 illness COVID-19 patient Deceased defined diagnose disease early stage fatty acids Final groups help hospital hospital discharge hospitalized patient hospitalized patients HPLC Human individual Infection information involved ketone ketone bodies mass spectrometry metabolism metabolite metabolomics Mild Mild disease negative control omeprazole outcome pandemic Patient patients plasma plasma sample plasma samples positive patient Potential biomarker potential biomarkers predict produced Prognosis purines respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe disease subsequent Tryptophan viral infection with mild disease [DOI] 10.1038/s41598-022-05667-0 PMC 바로가기 [Article Type] Article
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다Article Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제, [키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread [DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article
Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patientsCOVID-19 환자의 중증도 바이오마커로서의 기질 금속단백분해효소(MMP) 3 및 9Clinical Trial Published on 2022-01-242022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료법, [키워드] benefit Biomarker Biomarkers circulating neutrophil circulating neutrophils clinical heterogeneity contribute controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity disease severity Diseases Health Organization help Hospital admission Hospitalization hospitalized patient immunology inflammatory process interleukin-6 lung damage Lung inflammation matrix matrix metalloproteinases Medical research metalloproteinase MMP3 MMP9 molecular basis monocyte Monocytes myeloperoxidase Neutrophils no correlation occur pathogenic positively correlated Potential biomarker potential biomarkers predict progression Protein Proteins regeneration serum Serum level serum levels severe COVID-19 patient severe COVID-19 patients severe patients severity severity of COVID-19 significantly increased targeted therapy the WHO to define was increased was reduced WHO World Health Organization [DOI] 10.1038/s41598-021-04677-8 PMC 바로가기 [Article Type] Clinical Trial
Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission입원 시점에 COVID-19 관련 폐렴의 진행 및 임상 관리를위한 바이오 마커 후보Article Published on 2022-01-122022-09-10 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] administration Admission Biomarker Biomarkers candidate Candidates change Clinical management Clinical practice Coagulation COG5 complement Control COVID-19 COVID-19 prognosis Critical critical condition critical patients differentially expressed Evolution expression FDR FIVE glucocorticoid Glucocorticoids group Hospital admission Hospital stay hospitalized COVID-19 identify immunoglobulins Infectious diseases Inflammation Lipid metabolism MOST OAS3 over-expressed pathophysiology Patient patients plasma sample plasma samples Pneumonia Potential biomarker potential biomarkers priority Prognosis Prognostic factor progression Protein proteome reached Sample selected specific treatment Study design subject therapeutic strategy therapy Tocilizumab Treatment were used [DOI] 10.1038/s41598-021-04683-w PMC 바로가기 [Article Type] Article
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factorsCOVID-19는 분비된 대사 인자의 조절을 통해 새로운 발병 인슐린 저항성 및 지질 대사 조절 장애를 유발합니다Article Published on 2021-12-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Apelin Cohort complications COVID-19 COVID-19 patient Diseases dysregulation Endocrine system and metabolic diseases expression Glucose HDL-C hyperglycemia induce Infectious diseases insulin insulin resistance investigated isobutyric acid lipid metabolism lipids mechanism mechanisms metabolic factor metabolism modulated myeloperoxidase myostatin patients Perturbation Potential biomarker potential biomarkers potential therapeutic target potential therapeutic targets propionic acid Regulation reported REST resulting SARS-COV-2 infection secreted transcription factor transcriptional level [DOI] 10.1038/s41392-021-00822-x PMC 바로가기 [Article Type] Article
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
Perspectives on electrochemical biosensing of COVID-19Review article Published on 2021-12-012022-10-05 Journal: Current Opinion in Electrochemistry [Category] 바이오마커, [키워드] acute respiratory syndrome antibodies biosensor clinical setting coronavirus coronavirus disease COVID-19 COVID-19 infection Diagnosis Electrochemistry immune responses Infection novel nucleocapsid point of care point-of-care polymerase chain potential biomarkers Proteins Rapid reactive oxygen species SARS-CoV-2 time-consuming viral infections Viral proteins viral ribonucleic acid [DOI] 10.1016/j.coelec.2021.100794 [Article Type] Review article
Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this fieldCovid-19의 바이오 마커로서 miRNA의 역할 :이 분야의 연구를위한 상태와 향후 방향에 대한 범위 검토Review Published on 2021-11-172022-09-01 Journal: Biomarkers in Medicine [Category] MERS, 바이오마커, 진단, [키워드] animals Biomarker Biomarkers cardiovascular dysfunction carried Cell COVID-19 database described diagnosing Diseases dysregulated epigenomics identify immune response in viral independent infected cells material miR-126 miR-155 miRNA miRNAs nine patients with COVID-19 Potential biomarker potential biomarkers proliferation provide Replication Research resolved review role SARS-CoV-2 selected severity of COVID-19 suggested Viral viral replication [DOI] 10.2217/bmm-2021-0348 PMC 바로가기 [Article Type] Review