Early warnings of COVID-19 outbreaks across Europe from social mediaArticle Published on 2021-01-252022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] Applied mathematics Contagion COVID-19 outbreak Epidemiology Europe European Evidence geographical region help Infection information technology Local media Pneumonia proliferate raised Surveillance urgency [DOI] 10.1038/s41598-021-81333-1 PMC 바로가기 [Article Type] Article
Ramatroban as a Novel Immunotherapy for COVID-19Article Published on 2020-08-292022-10-31 Journal: Journal of molecular and genetic medicine : an international journal of biomedical research [Category] COVID-19, [키워드] activate adaptive immune responses airway allergic rhinitis Cell Concentration COVID-19 COVID-19 disease generate Host immune function Immunotherapy inhibiting Japan multiorgan failure novel PGD Platelet proinflammatory proliferate prostaglandin prothrombotic prothrombotic state Ramatroban receptor receptors respiratory safety profile SARS-CoV-2 virus stimulate suppresse Treatment virus [DOI] 10.37421/jmgm.2020.14.457 PMC 바로가기 [Article Type] Article
Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2Pharmacology Published on 2020-08-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Activation Alter Apoptosis cellular cellular immunity cellular metabolism Community coronavirus Critical defend evade event functions highlight host cell immune activation immune response infected cell Infection MAVS mechanism metabolism Mitochondria mitochondrial mitochondrial dynamics modulate modulating molecular organelle platform positive proliferate regulated Regulation replicate RNA coronavirus RNA virus RNA viruses ROS SARS-CoV-2 Signaling Stress subcellular survival Vaccine virus viruses while [DOI] 10.3389/fphar.2020.578599 PMC 바로가기 [Article Type] Pharmacology
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumoniaArticle Published on 2020-07-062022-10-04 Journal: Nature Communications [Category] SARS, 치료기술, 치료법, 치료제, [키워드] affected alteration anti-inflammatory cytokines both groups CD4 CD4-positive T cells CD57 CD8 cells central memory chemokine chemokine receptors condition COVID-19 COVID-19 patient cytokine production Cytokines effector memory flow cytometry healthy controls IL-17 immune system immunological Immunological memory interferon-γ Italy less lymphocyte Lymphocyte differentiation naïve Necrosis observation pandemic pathophysiological Patient patients with COVID-19 PD1 Peripheral blood Pneumonia proinflammatory proliferate public health Regulatory T cell required SARS-CoV-2 Significant significant increase T cell T cell activation T cells T helper terminally differentiated therapeutic strategy TNF transcription factor viral infection [DOI] 10.1038/s41467-020-17292-4 PMC 바로가기 [Article Type] Article
Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 특성, 진단 및 치료의 면역학적 측면Review Published on 2020-06-042022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, SARS, [키워드] advancement antibodies Antibody-dependent enhancement approach approaches caused Characteristics component components coronavirus coronavirus disease COVID-19 cytokine Cytokine storm Defense develop Diagnosis Diagnostic method diagnostic methods Diseases evade facilitate Health Organization Host Host immune response host immune responses host immune system immune attack immune response immune responses immune system Immunologic Infection Infectious disease Infectious diseases Inflammatory response Innate immunity knowledge Like Lungs mechanism new strain new strain of coronavirus other infectious diseases pandemic proliferate SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spread susceptible individuals the disease therapeutic agents Therapeutic strategies Treatment vaccination virus viruses World Health Organization [DOI] 10.1186/s12929-020-00663-w PMC 바로가기 [Article Type] Review
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathwaysResearch Article Published on 2017-08-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] aa deletion absence activate affected Analysis Apoptosis arginine cellular Characteristics Comparative conserved E protein eight envelope protein epidemic diarrhea ER stress expression Frame functional protein Genes genomic variation glycine GRP78 homologous host cell identification IL-6 IL-8 independent induce Infection membrane fusion morphology Mutation pathway PEDV potential mechanism pro-inflammatory cytokine proliferate proliferation protease Protein Receptor binding Replication responsible S2′ cleavage screened single mutation strain supplementary material transmembrane domain trypsin Variation Vero cells virion virus virus titer whole genome sequence α-coronavirus [DOI] 10.1186/s13567-017-0449-y PMC 바로가기 [Article Type] Research Article