Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unitSARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine Vaccine design variant wild type β-coronavirus [DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article
Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution시그니처 SNP를 기반으로 한 SARS-CoV-2 분기군 특성화, 지속적인 진화 공개Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] A97V Amino acid amino acid change amino acid changes biological function Biological functions carried change changes in Characteristics clade clades Cluster COVID-19 cure dataset Deleterious Deleterious mutations evaluate Evolution form Frequency globe identify MAFFT Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP NSP2 nsp4 nucleocapsid Occurrence ORF3a performed phylogenetic analyses Phylogenetic analysis PolyPhen-2 Protein protein structure PROVEAN Q57H RdRP Research responsible SARS-CoV-2 SARS-CoV-2 genome sequence Sequence alignment sequences signature SNP SNPs Spread stability strain T85I unique unique SNP unique SNPs used to evaluate vaccination Vaccine virus virus genome virus strain virus strains Wuhan Wuhan, China [DOI] 10.1016/j.ymeth.2021.09.005 PMC 바로가기 [Article Type] Article
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human ProteinsSARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens [DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol히노키티올과 함께 글루콘산아연에 의한 SARS-CoV-2 복제 억제Article Published on 2022-06-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome coronavirus antiviral therapy approach binding catalytic site chymotrypsin Combination Concentration coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 elevated Enzyme inhibition exhibited experimental evidence global public health gluconate hinokitiol in vitro inhibit inhibited inhibition inhibitory Ionophore mammalian cells metal ion MPro pandemic Papain Papain-like protease PLPro potential benefit potential benefits protease Protease activity Proteases protein structure proteolytic proteolytic activity residues respiratory SARS-CoV-2 SARS-CoV-2 replication screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 significantly small molecule target Treatment Zinc zinc gluconate Zinc gluconate. [DOI] 10.1016/j.jinorgbio.2022.111777 PMC 바로가기 [Article Type] Article
Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19COVID-19 제어를 위한 항균성 광역학 치료 잠재력의 분자 모델링 및 시뮬레이션 분석Article Published on 2022-05-312022-09-11 Journal: The Scientific World Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antimicrobial Antiviral binding binding mode binding modes bioinformatics can be used coil Computer simulation Control coronavirus COVID-19 Curcumin described ENhance evaluate functional Hierarchical host cell host cells identity in silico inhibiting Interaction modeling molecular molecular docking photodynamic therapy photosensitizer Physicochemical properties positive Positive Charge Potential predicted Protein protein structure protein-protein interaction random residue residues reveal SARS-CoV-2 secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike glycoprotein therapy viral cell viral infections viral surface was selected yield [DOI] 10.1155/2022/7089576 PMC 바로가기 [Article Type] Article
Structure-Based Development of SARS-CoV-2 Spike InteractorsSARS-CoV-2 스파이크 인터랙터의 구조 기반 개발Article Published on 2022-05-172022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor adopted affinities angiotensin approach B.1.617.2 binding binding affinity coronavirus Coronaviruses COVID-19 COVID-19 pandemic development diagnostic Dissociation constant domain ENhance etiological agent Host host cells human ACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infectious disease inhibit Interaction interfere melting temperature molecular molecular dynamics Protein protein structure RBD Receptor-binding domain Recognition S1 domain SARS-CoV-2 SARS-CoV-2 spike protein single-point mutations spike spike glycoprotein Spike protein stability starting temperature the SARS-CoV-2 the spike protein variant of SARS-CoV-2 viral entry [DOI] 10.3390/ijms23105601 PMC 바로가기 [Article Type] Article
Human-to-dog transmission of SARS-CoV-2, Colombia콜롬비아, SARS-CoV-2의 사람에서 개 전염Article Published on 2022-05-122022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 protein acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent clade close contact Complete conservation contribute coronavirus 2 COVID-19 pandemic docking E484K E484K mutation events Genome help hosts Human Latin America Lineage Localization molecular analysis Mutation non-human primates Phylogenetic prediction Prevent Protein protein structure public health RBD receptor Receptor-binding domain respiratory SARS-CoV-2 sequenced Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein symptomatic the receptor-binding domain the Spike Transmission transmission of SARS-CoV-2 viral infection viral sequence viral sequences virus [DOI] 10.1038/s41598-022-11847-9 PMC 바로가기 [Article Type] Article
Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2SARS-CoV-2에 대한 니클로사미드 유사체의 설계, 합성 및 생물학적 평가Article Published on 2022-05-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered analogue anti-SARS-CoV-2 applied autophagy Bioavailability blocked comparable Compound cytotoxicity Efficacy entry inhibition enzyme exhibited Fluorescence fluorescence microscopy half-life Human plasma hydrogen IMPROVE inhibit liver Microscopy molecular docking niclosamide oral bioavailability Phosphatidylserine Protein protein structure reduction Replication SARS-CoV-2 SARS-CoV-2 virus stability Stability test TMEM16F. was related [DOI] 10.1016/j.ejmech.2022.114295 PMC 바로가기 [Article Type] Article
Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine EscapeSARS-CoV-2 수용체 결합 도메인 인터페이스에서의 상위성과 백신 탈출에 대한 지루한 의미Article Published on 2022-04-262022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody appear approach binding site closely resemble Complete coronavirus COVID-19 pandemic Delta delta variant destabilize dominance Effect Efficacy emergence epistasis escape escape mutants escape mutation Evolution Gamma Gamma variant host receptor include Interaction interface majority multiple mutation mutants Mutation mutations neutralizing antibody omicron Omicron variant Omicron variants overlap Protein protein structure protein structure modeling. RBD RBD mutation RBD mutations RBD-ACE2 Receptor-binding domain reduce reduced repertoire respiratory resulting risk Rosetta SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus single mutant Spike protein the RBD the receptor-binding domain the SARS-CoV-2 the spike protein unlikely Vaccine vaccine efficacy Vaccines variant variants variants of SARS-CoV-2 virus wild type wild-type SARS-CoV-2 [DOI] 10.1128/mbio.00135-22 PMC 바로가기 [Article Type] Article
Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies백신 유도 및 치료 항체에 의한 중화에 대한 SARS-CoV-2 Omicron 변이체의 내성 증가Article Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antibody neutralization applied benefit BNT162b2 booster concern decrease disease severity Donor donors effective Effectiveness Efficacy Emergency use highlight immunization Increased incubated lentivirus Lilly luciferase luciferase activity luminometer maintain mapped Moderna monoclonal antibodies monoclonal antibody monoclonal antibody therapies monoclonal antibody therapy mutated neutralization Neutralizing NIH obstacle omicron Omicron variant Pfizer preventing infection PROTECT protein structure pseudotype pseudotyped lentiviruses Regeneron Resistance mutation resistance mutations SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant sera serum Sotrovimab Spike protein T cells target cells the vaccine the vaccines therapeutic Therapies therapy titre Vaccine vaccine efficacy variant was measured [DOI] 10.1016/j.ebiom.2022.103944 PMC 바로가기 [Article Type] Article