Establishment of the first Chinese national standard for protein subunit SARS-CoV-2 vaccine중국 최초의 단백질 소단위 SARS-CoV-2 백신 국가표준 제정Article Published on 2022-03-252022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] accelerated addition Antigen Antigen content approved asked assigned Biological Biological product calibration China Chinese Committee contribute Control COVID-19 Degradation detect determined by drug ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibited expression food house Laboratory linear relationship National national standard potency produced product Protein subunit Quality control reference material reference standard Reference standards returned SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines stability target proteins Vaccine was performed [DOI] 10.1016/j.vaccine.2022.02.048 PMC 바로가기 [Article Type] Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
Teaching an old dog new tricks: A lipid membrane-based electric immunosensor for real-time probing of the spike S 1 protein subunit from SARS-CoV-2늙은 개에게 새로운 트릭 가르치기: SARS-CoV-2의 스파이크 S 1 단백질 소단위의 실시간 조사를 위한 지질막 기반 전기 면역 센서Article Published on 2022-03-012022-09-11 Journal: Proteomics [Category] SARS, 치료기술, [키워드] ACE2 Adsorption alteration amplitude Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody changes in core correlated Disease diagnosis early disease extraction followed by human serum in vitro Interaction ionic strength lipid membrane membrane membrane potential membrane potential. monoclonal antibody pathogen Pathogens point-of-care Protein Protein subunit Proteins receptor recorded SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike S1 serum proteins shown spectral analysis Spike protein subunit Teaching the SARS-CoV-2 transmembrane Transmembrane potential [DOI] 10.1002/pmic.202100047 PMC 바로가기 [Article Type] Article
Neutralizing Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Induced by Natural Infection or Vaccination: A Systematic Review and Pooled Analysis중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 변이체에 대한 중화 항체 자연 감염 또는 예방 접종으로 유도: 체계적인 검토 및 통합 분석Article Published on 2022-03-012022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 변종, 진단, [키워드] (alpha (Beta) 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha antibody Antibody titers average B.1.1.7 B.1.351 B.1.617.2 collected coronavirus coronavirus 2 eligibility criteria escaped evaluated fold Immunity induced infected individuals Infection Lineage Live virus Messenger RNA natural natural infection neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers P.1 platform Protein subunit reduction in reductions in respiratory review SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants searched serum severe acute respiratory syndrome Coronavirus significant reductions significantly titers vaccination Vaccine vaccinee vaccinees variant variants [DOI] 10.1093/cid/ciab646 PMC 바로가기 [Article Type] Article
Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein자기 마이크로비드 친화성 선택 스크리닝의 발전: SARS-CoV-2 스파이크 단백질에 대한 천연 리간드의 발견Article Published on 2022-01-052022-09-11 Journal: Journal of the American Society for Mass Spectrome [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance affinity Amino acid amino acid sequence angiotensin Angiotensin converting enzyme-2 antibodies applied approaches binding caused complex coronavirus COVID-19 enzyme glycyrrhiza High-resolution HPLC human ACE2 human cell human cells include Interaction licochalcone a Ligand ligands Like mass spectrometry Microbead natural peptide pharmacological Prevent Protein subunit receptor robotics S1 protein SARS-CoV-2 SARS-COV-2 infection Selection sensitivity sequence severe acute respiratory syndrome Coronavirus small molecule Small molecules spike Spike protein subunit Tandem mass spectrometry targets the S1 protein the SARS-CoV-2 therapeutic agent therapeutic agents throughput treat virus spike protein [DOI] 10.1021/jasms.1c00318 PMC 바로가기 [Article Type] Article
Innovations and development of Covid-19 vaccines: A patent reviewReview article Published on 2022-01-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 신약개발, [키워드] Bacteria confirmed case country COVID-19 COVID-19 vaccine COVID-19 vaccines development DNA domain effective Innovation janssen Moderna Patent Protein subunit provide reported rising RNA SARS-CoV-2 viral spike (S) protein trials Vaccine Vaccines viral receptor-binding domain virus was done [DOI] 10.1016/j.jiph.2021.10.021 [Article Type] Review article
Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffiiCommunication Published on 2021-11-152022-10-27 Journal: Biotechnology and bioengineering [Category] COVID-19, [키워드] Antigen approach candidate Cell clinical trial COVID‐19 COVID‐19 Elimination genetic engineering Health Host methanol microbial microbial engineering other variant Pichia pastoris platform prevention Protein Protein subunit RBD receptor‐binding domain Recombinant protein removal reported SARS‐CoV‐2 secreted secreted protein Spike protein Stress Subunit vaccine the RBD protein transfer Vaccine vaccine antigen vaccine candidate vaccine candidates Vaccines yeast [DOI] 10.1002/bit.27979 PMC 바로가기 [Article Type] Communication
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.423 Published on 2021-08-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvanticity alum alum adjuvant antibodies antibody Antibody Response Antibody responses Antigen Blood bloodstream blunt CD4 Cell-mediated immunity coronavirus COVID-19 patients Efficacy Elastase ENhance epitope Epitopes follicular help identify IgA antibodies IgA antibody IL-1 Immunity immunization Immunoglobulin IMPROVE induce inhibition inhibitor injected innate response interleukin investigated lack magnitude mice mucosal mucosal immunity mucosal route mucosal secretion mucosal tissue mucosal tissues myeloid cells neutrophil Neutrophil elastase neutrophil elastase inhibitor Neutrophils pharmacological promote protective antibodies Protective antibody Protein Protein subunit protein-based vaccine recruitment regulate response responses SARS-CoV-2 SARS-CoV-2 spike protein sera Serine serine protease serum antibody serum IgG severe acute respiratory syndrome Coronavirus SIgA Significance Spike protein stimulate subunit Support suppression T cell T cell responses T helper Tfh Th1 Th2 the spike protein vaccination Vaccine Vaccines [DOI] 10.1073/pnas.2102435118 PMC 바로가기 [Article Type] 423
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans인간에서 COVID-19에 대한 백신 유도 보호의 면역학적 메커니즘Review Published on 2021-08-012022-09-11 Journal: Nature reviews. Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Adenovirus adenovirus vaccine antibody approval approved Cell COVID-19 COVID-19 vaccine detectable dose driving Effector mechanism Efficacy elicit functions Human identifying immune immune responses inactivated innate immune mechanism mechanisms moderate MOST mRNA mRNA vaccine NAb NAbs Neutralizing antibodies neutralizing antibody phase III trial Phase III trials Protein subunit reported response SARS-CoV-2 spike protein single dose Spike protein T cell T cell responses T cells T helper the SARS-CoV-2 These data Vaccine development Vaccines virus Virus neutralization [DOI] 10.1038/s41577-021-00578-z PMC 바로가기 [Article Type] Review
Antibody Responses and the Effects of Clinical Drugs in COVID-19 PatientsCOVID-19 환자에서 항체 반응과 임상 약물의 효과Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Affiliated Hospital Anti-RBD IgG anti-viral drug Anti-viral drugs antibody Antibody titer Arbidol Bilirubin Chloroquine clinical Clinical treatment collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed direct bilirubin disease drug Effect ELISA Epidemic epidemic disease glucocorticoid Host humoral Humoral response humoral responses hydroxybutyrate dehydrogenase IgG and IgM IgM antibodies Infection Inflammatory responses laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lymphocyte Patient peripheral lymphocyte plasma plasma sample plasma samples Protein Protein subunit RBD Receptor binding domain reduced response Ritonavir SARS-CoV-2 SARS-CoV-2 nucleic acid serum severe symptom severe symptoms significantly Specific specific antibodies specific antibody Spike protein subunit suggested Sun Yat-sen therapy total bilirubin university while α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/fimmu.2021.580989 PMC 바로가기 [Article Type] Immunology