protein synthesis – Page 2 – Communicable Diseases Research

Review of Ribosome Interactions with SARS-CoV-2 and COVID-19 mRNA Vaccine

Review

Published on 2022-01-012022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections

Article

Published on 2021-12-112022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Affect Analysis Antiviral antiviral drug combination antiviral property Calu-3 cell changes in clinical development Combination concentrations convalescent serum coronavirus cycloheximide demonstrated drug effective EIDD-2801 HCV hepatitis C virus hepatitis E virus HIV homeostasis Human immunodeficiency virus IFN IFNs IFNα in vitro indicated influenza A virus interferon interferon-alpha lung organoids metabolomic NITD008 organoids Other protein synthesis Remdesivir Replication ribavirin SARS-CoV-2 Side effects suppressed synergistic target tested therapeutic potential tolerable Transcription uninfected cell viral infections Viral RNA while
[DOI] 10.3390/v13122489 PMC 바로가기 [Article Type] Article

Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources

Review

Published on 2021-11-302022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] 3-chymotrypsin-like protease 3CLpro Antiviral Bacteria candidate caused Community Compound coronavirus 2 COVID-19 COVID-19 pandemic cysteine protease drug drug design drug target expand function fungi Health HIV protease inhibitor Host Infection information inhibitor inhibitors less microbial Modification nucleic acids nucleosides nucleotides Papain-like protease platform PLPro Potential protease Proteases Protein protein synthesis reported researcher resource respiratory RNA SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 proteases SARS-CoV-2 viral SARS-CoV2 Source Spread structures suggested the SARS-CoV-2 Transcription translation Treatment urgency virus virus replication while with COVID-19
[DOI] 10.3390/microorganisms9122481 PMC 바로가기 [Article Type] Review

Problem solving in the time of coronavirus pandemic

코로나 바이러스 전염병 시대의 문제 해결

Article

Published on 2021-11-012022-09-11
Journal: Biochemistry and Molecular Biology Education [Category] SARS, 유전자 메커니즘,

Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition

Microbiology

Published on 2021-09-282022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target

Prolyl 이성질 효소 PIN1은 SARS-COV-2 증식에서 필수적인 역할을하며, 이는 새로운 치료 표적으로서의 가능성을 나타낸다.

Article

Published on 2021-09-172022-09-10
Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단,

[키워드] activate Acute promyelocytic leukemia acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added addition APL ATRA cells cellular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CPE Culture culture medium Cytopathic effect drug Drug development expression global pandemic Infectious diseases inhibit inhibitor inhibitory effect leukemia medium molecular mechanism mRNA mRNA synthesis N protein novel Novel coronavirus novel coronavirus disease PIN1 potential therapeutic agent potential therapeutic agents proliferation Promyelocytic leukemia protein synthesis receptor reduced respiratory retinoic acid SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus siRNA suppressed Target identification therapeutic agents therapeutic target Transcription treat Viral
[DOI] 10.1038/s41598-021-97972-3 PMC 바로가기 [Article Type] Article

Human Codon Usage: The Genetic Basis of Pathogen Latency

Original Article

Published on 2021-09-142024-09-02
Journal: Global Medical Genetics [Category] 대상포진,

[키워드] (re)activation codon optimization codon usage cross-reactivity pathogen latency protein synthesis tRNAs
[DOI] 10.1055/s-0041-1729753 PMC 바로가기 [Article Type] Original Article

The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

엽산 길항제 메토트렉세이트는 코로나바이러스 SARS-CoV-2의 복제를 감소시키고 세포 배양 모델에서 렘데시비르의 항바이러스 효능을 향상시킵니다

Article

Published on 2021-09-012022-09-11
Journal: Virus research [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제,

[키워드] aberrant inflammatory response Aberrant inflammatory responses addition Antiviral antiviral activity antiviral agent antiviral efficacy benefit calu-3 cells Cancer therapy Cell culture Combination Concentration coronavirus coronavirus SARS-CoV-2 COVID-19 cultured cells decrease described dihydrofolate Dihydrofolate reductase diminishe dissemination distress drug Efficacy ENhance enzyme Enzymes Folic acid Folinic acid Frame host cell Immunosuppression impairment induce Infection inhibit inhibited Inosine Leucovorin limit mechanism methotrexate MTX nucleocapsid nucleotide nucleotides Organisms Perspective progeny protein synthesis purine Purine synthesis raise reduce reductions in released Remdesivir Replication replication of SARS-CoV-2 required rescued respiratory distress RNA RNA replication SARS-CoV-2 SARS-CoV-2 infections spike structural protein structural proteins synergistic synthesis tested therapeutic therapy Toxicity treating COVID-19 treating SARS-CoV-2 infection Vero Vero E6 virus virus replication virus RNA
[DOI] 10.1016/j.virusres.2021.198469 PMC 바로가기 [Article Type] Article

Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx

비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명

Research

Published on 2021-08-142022-09-10
Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

COVID-19 치료를 위한 해양 자원의 항바이러스 응용: 개요

Review

Published on 2021-07-232022-09-10
Journal: Marine Drugs [Category] SARS, 치료제,

[키워드] ACE-2 Algae anionic anti-inflammatory agent Anti-viral anti-viral effect Antiviral application Bacteria bromotyrosines Compound compounds conducted COVID-19 COVID-19 therapy Dexamethasone downregulate drug Drug discovery Efficacy focus Google Scholar highlight induce infected patients inhibit innate immune response inorganic lack leads life cycle M pro marine algae marine protein marine sponge market mechanism metabolite molecular weight organism pandemic phycocyanobilins polyp polysaccharide Prevent protease Protein protein synthesis Remdesivir Replication required resource SARS-CoV-2 SARS-CoV-2 infected patients shown sulfated polysaccharides therapy Treatment Viral viral entry viral life cycle
[DOI] 10.3390/md19080409 PMC 바로가기 [Article Type] Review