Sensitive and specific clinically diagnosis of SARS-CoV-2 employing a novel biosensor based on boron nitride quantum dots/flower-like gold nanostructures signal amplification질화붕소 양자점/꽃모양 금 나노구조 신호 증폭 기반의 새로운 바이오센서를 이용한 SARS-CoV-2의 민감하고 구체적인 임상 진단Article Published on 2022-07-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification biosensor Boron boron nitride carbon characteristic clinical sample clinical samples clinical trials clinically comparable COVID-19 COVID-19 outbreak COVID-19 pandemic cross-reactivity cutoff value Detection limit Diagnosis diagnosis of SARS-CoV-2 DNA Effect electrochemical biosensor evaluate form gold group growth Health Health crisis IAV Influenza influenza A Mutation nucleic acid nucleic acid amplification Patient platform point-of-care positive quantitation Quantitative receiver operating characteristic receiver operating characteristic curve remained RNA RNA fragment RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Screen sensitive sensitivity significant difference specificity ssDNA statistical analysis t-test virus diagnosis was tested [DOI] 10.1016/j.bios.2022.114209 PMC 바로가기 [Article Type] Article
Multiplexed reverse-transcriptase quantitative polymerase chain reaction using plasmonic nanoparticles for point-of-care COVID-19 diagnosis Research Published on 2022-07-012022-10-05 Journal: Nature nanotechnology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] amplified products can be used component COVID-19 diagnosis detect diagnostics Fluorescent probe human saliva molecular nasal offer optical point-of-care polymerase chain qPCR quantitation Quantitative Real-time monitoring RT-qPCR SARS-CoV-2 RNA SARS-CoV-2 variants sensitivity specificity specimen specimens vessel [DOI] 10.1038/s41565-022-01175-4 [Article Type] Research
Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids동시 분광형광법을 사용한 COVID-19 치료를 위한 FDA 승인 약물인 favipiravir 및 hydroxychloroquine의 정량 분석: 제약 제제 및 생물학적 유체에 적용Article Published on 2022-06-012022-09-11 Journal: Luminescence : the journal of biological and chemi [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acetate acute respiratory syndrome Analysis applied approach biological fluid biological fluids buffer cause caused condition contagious coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 country COVID-19 Detection limit diluent drug Drug administration Ethanol exhibited Favipiravir FDA-approved drug fluorescence intensity food harmonization Healthcare systems human plasma sample human plasma samples Hydroxychloroquine identify information Interference International Conference investigated limit limits medications Pharmaceutical Preparation pharmaceutical preparations quantitation SARS-CoV-2 sensitivity Severe acute respiratory syndrome synchronous synchronous fluorimetry. Treatment United State United States United States Food and Drug Administration viral infection were measured [DOI] 10.1002/bio.4240 PMC 바로가기 [Article Type] Article
A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab리툭시맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 혈청학적 반응과 관련된 요인Article Published on 2022-05-022022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated age analyzed angiotensin-converting enzyme 2 Anti-RBD IgG anti-receptor-binding domain Anti-spike anti-Spike IgG antibodies antibody B cells B-cell binding antibody CD19+ CD4+ T-cell CD8+ T-cell cellular response cohort study conducted COVID-19 infection Cutoff cutoff value Diagnosis disease dose Factor first vaccination Follow-up greater identify IgG IgG antibodies Immunoglobulin interferon gamma median monoclonal antibody Multiple multiple sclerosis Neutralizing outcome outcomes Patient patients evaluated peptide pool positive response positive test result proportion prospective cohort study quantitation RBD reached response rituximab SARS-CoV-2 sclerosis serological response spot-forming unit T-cell Response the median Treatment university hospital vaccination vaccine response Vaccines were assessed were measured women [DOI] 10.1001/jamanetworkopen.2022.11497 PMC 바로가기 [Article Type] Article
Ultrasensitive detection and quantification of viral nucleic acids with Raindance droplet digital PCR (ddPCR)Raindance droplet 디지털 PCR(ddPCR)을 사용한 바이러스 핵산의 초고감도 검출 및 정량화Article Published on 2022-05-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal models Antiretroviral therapy approaches assays caused Cell Combination cure Cure research ddPCR detect Detection sensitivity diagnosis and monitoring digital PCR disease DNA and RNA Efficacy example highlighting HIV HIV prevention HIV-1 HIV-1 infection HIV-1 viral immunodeficiency virus infected individual infected individuals Infection Infectious disease Infectious diseases inhibition inhibitors Interpretation model systems NHP non-human primate nucleic acid Nucleic acid detection nucleic acids outcome platform predictor progression quantification quantitation Raindance reduced required Research reverse transcription rhesus macaque rhesus macaques RNA RT-ddPCR SARS-CoV2 sensitive Simian simian immunodeficiency virus SIV step tissue tissues Treatment treatment intervention treatment interventions viral DNA viral nucleic acid viral nucleic acid detection viral nucleic acids Viral reservoir virus viruses [DOI] 10.1016/j.ymeth.2021.04.025 PMC 바로가기 [Article Type] Article
A Portable Nanoprobe for Rapid and Sensitive Detection of SARS-CoV-2 S1 ProteinSARS-CoV-2 S1 단백질의 신속하고 민감한 검출을 위한 휴대용 나노프로브Article Published on 2022-04-112022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 receptor applied clinical sample clinical samples complementary contaminated surface contaminated surfaces coronavirus COVID-19 COVID-19 infection detect detection Detection limit diagnostic eliminating generate help Infectious virus inherent Laboratory Laboratory report lactoferrin linear low-cost diagnostic assay MERS MERS-CoV onsite detection optical PCR testing positive result quantitation Rapid rapid biosensors. receptor SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike protein sensitive simple Spike protein the SARS-CoV-2 zone [DOI] 10.3390/bios12040232 PMC 바로가기 [Article Type] Article
A Novel Quantitative Multi-Component Serological Assay for SARS-CoV-2 Vaccine EvaluationSARS-CoV-2 백신 평가를 위한 새로운 정량적 다성분 혈청학적 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료법, [키워드] Accuracy Algorithm Analysis anti-SARS-CoV-2 array assays carried clinical trials conditions COVID-19 exposure times fluorescent generate house humoral Humoral response IgA IgG IgM Immunoglobulin immunoglobulins International international standard linear linearity methodology Microarray naïve normalized novel Nucleocapsid proteins positive Precision q-RT-PCR qRT-PCR quantitation Quantitative Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 patients SARS-CoV-2 spike SARS-CoV-2 vaccines sera seroconverted serum Specific specificity the microarray the SARS-CoV-2 the WHO unique Vaccine [DOI] 10.1021/acs.analchem.1c05264 PMC 바로가기 [Article Type] Article
The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patientsSARS-COV-2 양성 환자에서 N501Y 돌연변이의 잠재적 글로벌 영향 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Analysis approach average Chain Reaction Contagion contribute coronavirus evaluate examined FAM female global pandemic groups Health authority male medium Mutation mutation rate mutations N501Y N501Y mutation Patient PCR PCR test polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) positive positive patient positive sample Precaution Public public health public health authorities quantitation Randomly ranged Rapid retrospective reverse transcription PCR reverse transcription PCR (RT-PCR). RT-PCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread virus [DOI] 10.1002/jmv.27413 PMC 바로가기 [Article Type] Article
Assessment of Diagnostic Specificity of Anti-SARS-CoV-2 Antibody Tests and Their Application for Monitoring of Seroconversion and Stability of Antiviral Antibody Response in Healthcare Workers in MoscowArticle Published on 2022-02-122022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] anti-S antibody anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgM Anti-spike antibodies antibody Antibody testing Antigen application assessment average collected Concentration COVID-19 COVID-19 pandemic COVID-19 vaccination Decline diagnostic Frequency healthcare personnel Healthcare professional healthcare worker Healthcare workers IgM increased risk individual infected individuals Infection laboratory diagnosis monitoring Numerous pandemic positive proportion quantitation rapid increase remained response SARS-CoV-2 Seroconversion seropositive Significant specificity stability Test vaccination Vaccine hesitancy vaccine-induced antibody response virus was performed worker [DOI] 10.3390/microorganisms10020429 PMC 바로가기 [Article Type] Article