Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기
A Recombinant VSV-Based Bivalent Vaccine Effectively Protects against Both SARS-CoV-2 and Influenza A Virus InfectionArticle Published on 2022-09-282022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 신종인플루엔자, 진단, [키워드] Amino acid animal Bivalent bivalent vaccine C-terminal Cellular immune response conserved contagious COVID-19 Delta delta variant develop domain Ebola ectodomain Efficacy Evidence fused global public health glycoprotein H1N1 H3N2 hamster humoral immunization infections Infectious disease Influenza influenza A virus influenza virus influenza viruses M2 protein mice Neutralizing neutralizing antibody Point mutation PROTECT Protein provide recombinant reduced Respiratory disease respiratory droplet respiratory viral S2 domain SARS-CoV-2 SARS-CoV-2 Delta variant SARS-CoV-2 SP SARS-CoV-2 variant shown significantly Spike protein spike protein. the RBD threat transmitted Vaccine vaccine candidate vaccine platform variant vesicular stomatitis virus VSV VSV vector [DOI] 10.1128/jvi.01337-22 PMC 바로가기
Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its DruggabilityArticle Published on 2022-09-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료제, [키워드] activated active sites binding pocket binding site caused changes in conformational change CoV COVID-19 COVID-19 pandemic cryptic pocket cysteine protease develop drug druggability druggability. drugs help induce inhibitor inhibitors MixMD New coronavirus outbreak pandemic Pathogenesis patients physicochemical property PLPro predict probe Probeview promote Protein Research residue Respiratory disease resulting SARS-CoV-2 SARS-CoV-2 PLpro Schrodinger Site solvent target protein TRAPP treat virus was used [DOI] 10.3390/ijms231911265 PMC 바로가기
Two Years into the COVID-19 Pandemic: Lessons LearnedArticle Published on 2022-09-092022-11-16 Journal: ACS Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome caused Clinical features clinical manifestations coronavirus coronavirus disease Coronaviruses COVID-19 Diagnosis disease Epidemiology etiology global public health highlighting highly pathogenic hosts impacted IMPROVE knowledge lesson management pathophysiology prevention public health authority reservoir hosts Respiratory disease SARS-CoV-2 selected Topic Transmission Treatment Vaccines variants variants. virulent virus widespread Wuhan, China Year [DOI] 10.1021/acsinfecdis.2c00204 PMC 바로가기
Role of Breath Biopsy in COVID-19Article Published on 2022-09-012022-11-15 Journal: The journal of applied laboratory medicine [Category] 바이오마커, [키워드] affected Analysis approach biochemical Biomarker Biomarkers biopsy breath breath analyzers caused contagious country Coverage COVID-19 COVID-19 diagnosis diagnosis of COVID-19 healthcare mass spectrometry. noninvasive reproducibility Respiratory disease role SARS-CoV-2 sensitivity specificity transmitted VOCs [DOI] 10.1093/jalm/jfac040 PMC 바로가기
Network meta-analysis of deaths from various underlying diseases after COVID-19 infectionArticle Published on 2022-08-252022-11-16 Journal: Frontiers in Public Health [Category] meta-analysis, [키워드] Care Cerebrovascular disease Chronic kidney disease chronic liver disease Coronary heart disease coronary pneumonia COVID-19 COVID-19 infection COVID-19 with underlying diseases cumulative death death factors of new coronary pneumonia diabetes diagnosed with COVID-19 different disease disease Diseases Ethical approval Factor hypertension IMPROVE infected with COVID-19 kidney malignant tumor management men Meta-analysis Mortality network Network meta-analysis new coronary pneumonia complications novel coronary pneumonia Novel coronavirus Patient peer-reviewed Prognosis prognosis of novel coronavirus. prognosis of patients provided required Research Respiratory disease risk factor statistically significant subject submitted SUCRA underlying disease women [DOI] 10.3389/fpubh.2022.959073 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Dose, Infection, and Disease Outcomes for Coronavirus Disease 2019 (COVID-19): A Review코로나바이러스 질병 2019(COVID-19)에 대한 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 용량, 감염 및 질병 결과: 검토Review Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age animal model animal models animals Characteristics clinically Comorbidities coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determinant disease disease severity dose Dose-response dose-response relationship Epidemiology Evidence Factor future infection Host humans identify include Infection infectious dose inoculum inoculum. knowledge Mild mild to moderate moderate outcome pathogenicity Pregnancy Research respiratory Respiratory disease review SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 Sex smoking variants variants of concern [DOI] 10.1093/cid/ciab903 PMC 바로가기 [Article Type] Review
Diagnostic Approaches For COVID-19: Lessons Learned and the Path ForwardArticle Published on 2022-08-232022-11-15 Journal: ACS Nano [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome adopted advanced materials Antigen antigen tests biosensing caused Characteristics coronavirus Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic criteria Defense develop diagnostic diagnostic tests Diseases early diagnosis effective ENhance evaluated Evolution feasibility Forward Government Guidance highest imperative Infection Infectious diseases lesson limitation molecular Molecular tests MONITOR Nanomaterial Nanotechnology outbreak pandemic pandemic preparedness. path Perspective platform rate of infection reduce Respiratory disease resulting SARS-CoV-2 Spread Stage transmitted Treatment Vaccines viral infections Virological virological tests virus virus detection widespread [DOI] 10.1021/acsnano.2c01697 PMC 바로가기
Comparison between the persistence of post COVID-19 symptoms on critical patients requiring invasive mechanical ventilation and non-critical patientsObservational Study Published on 2022-08-222022-10-04 Journal: PLoS ONE [Category] SARS, 임상, [키워드] addition adjusted affected association Asymptomatic Care Cognitive impairment collected complications coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 symptom Critical develop discharged Dyspnea eligible patient evaluate fatigue Follow-up headache Health Assessment hospital Hospital stay Hospitalization ICU IMV intubation Invasive mechanical ventilation median age men multisystemic multivariate analysis Musculoskeletal musculoskeletal symptom Neuropsychiatric participant Patient patients performed persistence physician predominant proportion Psychological questionnaire reported required Respiratory disease severe COVID-19 disease significant difference Symptom Symptoms syndrome [DOI] 10.1371/journal.pone.0273041 PMC 바로가기 [Article Type] Observational Study
Protective role of zinc in the pathogenesis of respiratory diseases Reviews Published on 2022-08-182022-10-05 Journal: European journal of clinical nutrition [Category] 치료제, [키워드] Analysis Anti-inflammatory antioxidant Antiviral Apoptosis cancer cell disease Effect highlight immune In vitro studies Inflammation inhibit lipid metabolism Lung diseases Lungs morbidity and mortality oxidative stress Pathogenesis Perspective Protective effects protective mechanism provide regulate Regulation Research respiratory Respiratory disease respiratory diseases subjects therapy variety [DOI] 10.1038/s41430-022-01191-6 [Article Type] Reviews