FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generationArticle Published on 2021-12-012022-10-04 Journal: Free radical biology & medicine [Category] SARS, 신약개발, [키워드] A549 cell A549 cells alveolar Analysis approved blocker calcium channel Calcium channel blocker can be used CCB CCBs Cell cell damage cell death cellular cellular and molecular confocal microscopy COVID-19 cytosolic evaluated examined FDA hypoxia hypoxic ImageJ individual cell inducer L-type lung epithelial cell mitochondrial Mitochondrial calcium modulation molecular morphology Nifedipine nuclear oxygen pathophysiology platform Protective protective effect Quantitative analysis reactive oxygen species (ROS) reduce reduction required ROS ROS production SARS-CoV-2 significant increase suggested targets therapeutic trials viability was used [DOI] 10.1016/j.freeradbiomed.2021.08.245 PMC 바로가기 [Article Type] Article
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and TherapiesSARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법Review Published on 2021-09-212022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin [DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review
Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian CellsReview Published on 2021-05-282022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activate addition Affect amplify autophagy Bacteria cell death Defense described Effect Endoplasmic reticulum ER stress Host immune induce Infection Inflammation Innate immunity Interaction Intracellular mechanism mechanisms microbial Mitochondria oxidative stress pathogen Pathogens reactive oxygen specy regulate Regulation Reticulum ROS ROS production Specy Stress [DOI] 10.3390/antiox10060872 PMC 바로가기 [Article Type] Review
CD71 + Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal MiceImmunology Published on 2020-11-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] abrogated activated Against age apocynin appear Asymptomatic Bacteria Blood Bone marrow Brain CD14 CD45 CD71+ erythroid cells compromise control group COVID-19 COVID-19 infection cytokine production Diseases erythroid explain expressing Frequency highlight Human Immune cell immune system Immunosuppression immunosuppressive in vitro Infant Infants Infection Listeria monocytogene liver mechanism mice Mild monocyte Neonatal neonatal infections Neonate Newborn Newborns Older Peripheral blood physiological potential mechanism precursor property proportion reactive oxygen specy reduction in regulated response ROS ROS production significantly higher spleen suppressed survival rate susceptibility susceptible systemic T cells these cell [DOI] 10.3389/fimmu.2020.597433 PMC 바로가기 [Article Type] Immunology
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart FailureReview Published on 2020-11-142022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor Activation acute respiratory syndrome adipocyte adipocytes administration adverse outcome amplification amplify antioxidant Cell complex Concentration coronavirus coronavirus disease COVID COVID-19 Cytokine storm Cytokines Cytokines storm death degrade demonstrated development drug enzyme exacerbate Express expression failure fat form global pandemic group heart heart failure heme oxygenase increase infected with COVID-19 Infection Inflammatory cytokine Inflammatory mediators Laboratory Modification Na/K-ATPase obese obese patients obesity pandemic Patient peptide Proteins reactive oxygen species reactive oxygen specy receptor reduction regulate renal responsible risk RNA role ROS ROS production SARS-CoV-2 selective shown Signaling subjects subunit susceptibility systemic systemic cytokine systemic inflammation tissue virus white with COVID-19 [DOI] 10.3390/antiox9111129 PMC 바로가기 [Article Type] Review
Salmonella enterica serotype typhimurium and S. Stanley differ in genomic evolutionary patterns and early immune responses in human THP-1 cell line and CD14+ monocytesarticle Published on 2019-04-302024-09-01 Journal: Comparative Immunology, Microbiology and Infectious Diseases [Category] 살모넬라증, [키워드] Cytokines Monocytes Prevalence ROS production Salmonella Stanley Salmonella Typhimurium [Article Type] article
Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogensHeme peroxidase HPX-2는 Caenorhabditis elegans를 병원체로부터 보호합니다Research Article Published on 2019-01-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Author Caenorhabditis elegan Caenorhabditis elegans catalytic cause changes in characterization complexity component conditions contribute Defense demonstrated Disruption DNA domain downstream elegan elegans ENCODE enzyme exhibited expression fluorescent function generate genes encoding greater heme Host host defense host tissue hydrogen hydrogen peroxide hypodermis indicated Infection Infectious disease Infectious diseases information Innate immunity intestinal involved labeling limit mammalian mechanism microbe microbial microbial infection morbidity morbidity and mortality Morphological mutant NADPH NADPH oxidase observation organ oxygen pathogen pathogenic Pathogens pathway peroxidase peroxidases pharynx previous study PROTECT Protective Reactions reactive oxygen species regulated required residue RNA interference RNA-seq analysis RNAi ROS ROS production shown survival therapy tissue worm [DOI] 10.1371/journal.pgen.1007944 PMC 바로가기 [Article Type] Research Article
Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 CellsMicrobiology Published on 2017-02-012022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, [키워드] Apoptosis cell types cells coronavirus damaged demonstrated dose doxycycline Effect Evidence facilitated gastroenteritis IFN-β induce inhibit interrupt intestinal epithelium IPEC-J2 cells mitochondrial mitophagy morphology Production proliferation reactive oxygen specy Replication required ROS ROS production significantly TGEV viral infection [DOI] 10.3389/fcimb.2017.00021 PMC 바로가기 [Article Type] Microbiology
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant HepatitisResearch Article Published on 2015-09-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type [DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
Anti-dermatophytic activity of bakuchiol: In vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model바쿠치올의 항진균 활성: 시험관 내 기전 연구 및 기니피그 모델에서의 인체 사지 백선 억제 활성journal-article Published on 2014-06-012024-08-01 Journal: Phytomedicine [Category] 백선증, [키워드] Antifungal bakuchiol membrane permeability ROS production tinea pedis Trichophyton mentagrophytes [DOI] 10.1016/j.phymed.2014.03.005 [Article Type] journal-article