Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variantsArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] anti-S IgG antibody Antigen antigens B.1.1.529 B.1.1.7 B.1.617.2 binding can be used comparable COVID-19 COVID-19 pandemic current Delta demonstrated Detection limit Diagnosis diagnostic Direct dropped ELISA finding Flow fluorescent Fluorescent nanodiamond incubated Infectious disease Laboratory Lateral lateral flow immunoassay limitations membrane mutations NC membrane nonspecific omicron platform Protein public health Quantitative reporter responsible S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SELFIA. Spike protein suggested the SARS-CoV-2 turnaround times variant variants viruses was performed wild-type Wuhan-1 [DOI] 10.1016/j.aca.2022.340389 PMC 바로가기
Measurement of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens in Plasma of Pediatric Patients With Acute Coronavirus Disease 2019 or Multisystem Inflammatory Syndrome in Children Using an Ultrasensitive and Quantitative ImmunoassayArticle Published on 2022-10-122022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 치료기술, [키워드] 24 hour acute COVID-19 acute respiratory syndrome Antigen antigenemia Blood blood collection blood draw CDC criteria children Concentration contribute Control coronavirus coronavirus 2 coronavirus disease correlated COVID-19 COVID-19 patient cycle threshold detection diagnostic disease severity enrolled highest hospital immunoassay Inflammatory Inpatient measurement Meso Scale Discovery MIS-C nasopharyngeal Nasopharyngeal swab negative RT-PCR Pathogenesis Patient patients Pediatric patient plasma positive quantified ranged recent respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 nucleocapsid SARS-CoV-2 RT-PCR SARS-CoV-2 spike sensitivity serology syndrome tested the patient ultrasensitive immunoassay. undetectable was collected [DOI] 10.1093/cid/ciac160 PMC 바로가기
Real-time monitoring of isothermal nucleic acid amplification on a smartphone by using a portable electrochemical device for home-testing of SARS-CoV-2Article Published on 2022-10-092022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute infectious disease approach automatically Bluetooth caused comparable criteria demonstrated Electrochemical detection exhibited Infectious disease isothermal Isothermal nucleic acid amplification linear nucleic acid nucleic acid amplification pandemic of COVID-19 pH value pH-sensitive potentiometric sensor. Protein Real-time monitoring resource SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid sensitivity Smartphone utility [DOI] 10.1016/j.aca.2022.340343 PMC 바로가기
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19Article Published on 2022-10-012022-11-16 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute SARS-CoV-2 infection antibody Antigen baseline Biomarker body mass index Characteristics Clinical outcome clinically COVID-19 cross-sectional study delta variant discharge elevated ENhance enrolled Enrollment evaluate evaluated Factor Government greater higher odd hospital Hospital admission hospital discharge Hospitalized hospitalized patient hospitalized patients identify immunocompromising condition Infectious diseases Inpatient Laboratory less Level Logistic regression Male sex median Multiple multivariable N antigen nasal nasal swab Noninvasive ventilation Odds ratio operation outcome outcomes participant pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 Patient patients with COVID-19 plasma Platform trial point-of-care polymerase chain predict quantification regression models Remdesivir renal impairment SARS-CoV-2 SARS-CoV-2 nucleocapsid severity speed Support Symptoms Therapeutics transcriptase viral replication was determined was measured were assessed worsened worsening [DOI] 10.7326/M22-0924 PMC 바로가기
Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticalsArticle Published on 2022-10-012022-11-15 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened [DOI] 10.1111/jfbc.14262 PMC 바로가기
A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patientsCOVID-19 감염 환자의 소음이 없고 자체 검증된 장애 감지를 위한 소형의 저비용 바이너리 감지(BiSense) 플랫폼Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료기술, 치료법, [키워드] acquisition added advancement Alpha Analysis approach Bi-potentiostat Biomarkers biosensor complex components COVID-19 infected patient creating Diagnosis electrical electrochemical biosensing electrode infections less matrix effect multiplex N-protein nasopharyngeal platform point-of-care Protein Quantitative Rapid Rapid tests reliability reported SARS-CoV-2 SARS-CoV-2 nucleocapsid shelf swab samples variant was used [DOI] 10.1016/j.bios.2022.114459 PMC 바로가기 [Article Type] Article
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19Article Published on 2022-09-142022-11-15 Journal: Critical Care [Category] SARS, 치료기술, [키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization [DOI] 10.1186/s13054-022-04153-3 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Antigen in Urine of Hospitalized Patients With Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] absence Accuracy acute respiratory syndrome Admission antibodies Blood C-reactive protein Compound coronavirus coronavirus 2 coronavirus disease Course COVID-19 disease severity dissemination early phase hospitalized patient immunoassay Infection intensive care units lactate dehydrogenase lymphopenia marker nucleocapsid nucleocapsid antigen Patient patients hospitalized patients with SARS-CoV-2 plasma polymerase chain positive reflect respiratory SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 nucleocapsid severe COVID-19 severity Severity of disease tested urinary Urine [DOI] 10.1093/infdis/jiac073 PMC 바로가기
Rapid magneto-enzyme-linked immunosorbent assay for ultrasensitive protein detection초민감성 단백질 검출을 위한 신속한 자기효소 결합 면역흡착 분석Article Published on 2022-09-082022-11-16 Journal: Analytica chimica acta [Category] SARS, 말라리아, 치료기술, [키워드] Accuracy addition amplification analytical sensitivity Biomarker blood sample Clinical practice coated with Concentration detect detection antibody diagnosing diagnostic diagnostics disease ELISA ELISA kit enzyme-linked immunosorbent equipment exhibited gold standard handling HRP human serum immunoassay immunosorbent individual Infection Laboratory limit of detection Magnetic nanoparticles malaria measurement Medical conditions microplate reader offer P. falciparum peroxidase PfHRP2 Plasmodium falciparum platform Protein protocols Rapid SARS-CoV-2 SARS-CoV-2 nucleocapsid specimen Standard of care unique was used [DOI] 10.1016/j.aca.2022.340246 PMC 바로가기
Self-administered, remote assessment of SARS-CoV-2 seroprevalence in health care workersArticle Published on 2022-09-012022-11-15 Journal: The American journal of the medical sciences [Category] SARS, 진단, [키워드] clinician Cohort Community conducted Control enrolled Estimated Evidence Health care worker health care workers identify IgG immunoassay Infection infection rate lateral flow not differ Nurse point-of-care reported SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 seroprevalence serologic testing seropositive subject the epidemic was performed widespread [DOI] 10.1016/j.amjms.2022.01.025 PMC 바로가기