serine 2 – Page 2 – Communicable Diseases Research

A New Perspective of COVID-19 Infection: An Epigenetics Point of View

Review Article

Published on 2022-03-192022-10-31
Journal: Global Medical Genetics [Category] COVID-19,

In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation

분자 도킹 시뮬레이션을 사용한 SARS-CoV-2의 잠재적 억제제로서의 천연물 스크리닝

Article

Published on 2022-03-012022-09-11
Journal: Chinese journal of integrative medicine [Category] SARS, 치료제,

[키워드] 3CL 3CL pro ABL1 acting activated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme anti-SARS-CoV-2 berbamine betulinic acid binding affinity calcineurin carried Cepharanthine chymotrypsin Chymotrypsin-like protease Compound compounds coronavirus derivative drug emodin enzyme glucogallin homolog human coronaviruses in-silico juglanin leukemia molecular molecular docking molecular docking studies Molecular docking study MOST murine natural natural products-derived anti-SARS-CoV-2 candidates NFAT non-structural protein nonstructural proteins nsp10 nsp13 nsp14 Nsp15 Other Papain Papain-like protease performed Potential product protease Protein quercetin RdRP receptor RNA-dependent RNA polymerase S protein SARS-CoV-2 screened Screening Serine serine 2 severe acute respiratory syndrome Coronavirus Simulation spike glycoprotein structural proteins T-cell T-cells tanshinone tanshinone I target target protein target proteins these compound these compounds transmembrane
[DOI] 10.1007/s11655-021-3504-5 PMC 바로가기 [Article Type] Article

Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy

신종 코로나바이러스 감염증 2019(COVID-19) 및 잠재적 치료법으로서의 황화수소의 신장 결과

Review

Published on 2022-03-012022-09-11
Journal: Nitric oxide : biology and chemistry [Category] SARS, 바이오마커, 치료제,

[키워드] Acute kidney injury addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Anti-inflammatory antioxidant Antiviral antiviral agent Antiviral agents Cancer caused cells Chronic kidney disease clinical study condition consequence coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Diabetic diabetic nephropathy dialysis enzyme exhibit expression facilitate global pandemic H(2)S donors humans hydrogen Hydrogen sulfide Hydrogen sulfide (H(2)S) increase interleukin-6 kidney Kidney disease kidney dysfunction Kidney injury kidney transplant manifestation Mortality nephropathy Novel coronavirus novel coronavirus disease patients Pneumonia potential therapy prevalent protease reduced renal Renal cancer Respiratory illness SARS-CoV-2 Serine serine 2 serum SULFIDE survivor therapeutic therapy transmembrane transmembrane protease serine 2 Treatment virus
[DOI] 10.1016/j.niox.2022.01.002 PMC 바로가기 [Article Type] Review

Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2

중증 급성 호흡기 증후군 코로나바이러스 2에 대한 억제제로서의 타페노퀸 및 그 유도체

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Biological Chemistry [Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected antimalarial antimalarial drug approved catalysis catalytic caused complex Compound coronavirus COVID-19 crystal structure Cys145 derivative drug drug action Drug administration drug design Drug discovery effective food Food and Drug Administration identify infectibility Infection inhibit inhibited inhibitor library M pro main protease malaria maturation mutant pandemic peptide Plasmodium vivax Prophylaxis protease Protease activity radical cure rising SARS-CoV-2 SARS-CoV-2 main protease screened Serine serine 2 severe acute respiratory syndrome Coronavirus substrates tafenoquine the SARS-CoV-2 therapeutic therapeutic index therapeutic target TMPRSS2 transmembrane Treatment variants viral protease Viral protein virus entry
[DOI] 10.1016/j.jbc.2022.101658 PMC 바로가기 [Article Type] Article

Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

다양한 세포 유형에서 SARS-CoV-2 감염에 대한 비교 연구: 잠재적 수용체의 역할에 대한 생물물리학적 전산적 접근

Article

Published on 2022-03-012022-09-12
Journal: Computers in biology and medicine [Category] MERS, SARS, 진단,

[키워드] A549 ACE2 addition AGTR2 angiotensin-converting enzyme 2 approach CD147 Cell cell line cell lines Cell susceptibility cellular Comparative conditions dependent on docking early infection expected experiment expression expression level expression levels greater Heat shock HEK293 HepG2 Host host protein HSPA5 Infection Interaction kinetic less Lungs macromolecular Macromolecular crowding membrane NRP1 NTERA-2 parameter predict predicted promote protease Protein Quantitative receptor receptors Research respiratory tract SARS CoV-2 SARS-COV-2 infection serine 2 stimulate susceptibility TMPRSS2 transcriptomic data transmembrane viral dynamics viral growth viral spike Viral spike. virus
[DOI] 10.1016/j.compbiomed.2022.105245 PMC 바로가기 [Article Type] Article

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity

Article

Published on 2022-02-272022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] 3CLpro ACE2 acid acute respiratory syndrome angiotensin-converting enzyme 2 approach bind binding biochemical building cell membrane Combination Compound coronavirus coronavirus disease COVID-19 Effect Extracellular higher affinity Host Infectivity inhibit Inhibition assays inhibitors Interaction involved Ligand molecular molecular docking molecular dynamics organism pandemic physicochemical polyphenols Prevent protease RBD Receptor binding domain Replication SARS-CoV-2 SARS-CoV-2 cell serine 2 Spike protein Structural properties target target receptor targets the SARS-CoV-2 TMPRSS2 transmembrane
[DOI] 10.3390/ijms23052643 PMC 바로가기 [Article Type] Article

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

천연물 갈린아미드 A 및 카텝신 L의 억제를 통한 유사체에 의한 강력한 항-SARS-CoV-2 활성

Article

Published on 2022-02-242022-09-11
Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected
[DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology

Possible kidney-lung cross-talk in COVID-19: in silico modeling of SARS-CoV-2 infection

COVID-19에서 가능한 신장 폐 크로스 토크 : SARS-COV-2 감염의 실리코 모델링에서

Research Article

Published on 2022-02-052022-09-10
Journal: BMC Nephrology [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘,

[키워드] ACE2 Acute kidney injury affected AKI angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Candidates caused cell entry change changes in COVID receptors COVID-19 COVID-19 infection cross-talk dataset downregulated Effects enzyme evaluated experimental model experimental models expression fold Gene Expression Genes Genomics hypothese in silico in silico analysis in silico Approach Inhbb Injury Invasion involved kidney Kidney-lung cross-talk kidneys Lcn2 leads lung Lung injury Lungs Maff mechanical ventilation mechanism Microarray molecular mouse model Mouse models organs Pneumonia progression protease question Result reveal SARS-CoV-2 SARS-COV-2 infection Serine serine 2 SOCS3 target targets TMPRSS2 transmembrane transmembrane protease serine 2 upregulated while
[DOI] 10.1186/s12882-022-02682-1 PMC 바로가기 [Article Type] Research Article