Measurements of SARS-CoV-2 antibody dissociation rate constant by chaotrope-free biolayer interferometry in serum of COVID-19 convalescent patients코로나19 회복기 환자의 혈청 내 무카오트로프 생물층 간섭계를 통한 SARS-CoV-2 항체 해리율 상수 측정Article Published on 2022-08-012022-09-12 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, [키워드] Antibody concentrations avidity binding binding interaction binding kinetics Biolayer interferometry BLI children Clinical use clinical utility coated with convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient Critical demonstrated dissociation dissociation rate Dissociation rate constant Efficiency functional intensity Kinetics knowledge Lower measurement non-specific pediatric probe RBD Real-time monitoring Receptor binding domain reduction reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike protein sera serum serum albumin serum antibody Vaccines were measured [DOI] 10.1016/j.bios.2022.114237 PMC 바로가기 [Article Type] Article
Mortality Predictors in Severe SARS-CoV-2 InfectionObservational Study Published on 2022-07-182022-10-05 Journal: Medicina [Category] COVID19(2023년), SARS, 임상, [키워드] Admission age Algorithm changes in Cluster Clusters Community COVID-19 CT scan density clusters element evaluate evaluated Evolution form hemoglobin high mortality hospital hypoxic respiratory failure IMPROVE include increase interstitial lactate dehydrogenase lesions less lung lung involvement lung lesion Lymphocytes material Mortality Myoglobin non-survivor Non-survivors objective Observational cohort study oxygen flow PaO parameter parameters Patient performed Platelets Prediction score Predictive predictor Prognosis pulmonary involvement pulmonary lesion Quantitative quantitative evaluation radiological raising Regression model Result retrospective risk factor SARS-CoV-2 SARS-CoV-2 pneumonia semi-quantitative Sensitivity and specificity serum albumin serum creatinine Severe case severe COVID-19 Survivors [DOI] 10.3390/medicina58070945 PMC 바로가기 [Article Type] Observational Study
Circulating suPAR associates with severity and in-hospital progression of COVID-19순환하는 suPAR은 COVID-19의 중증도 및 병원 내 진행과 관련이 있습니다.Observational Study Published on 2022-07-012022-09-11 Journal: European Journal of Clinical Investigation [Category] MERS, 바이오마커, 임상, [키워드] 95% CI Accuracy Admission Adult patients age albumin assays association AUC best characterized clinical correlated COVID-19 COVID-19 disease CRP discrimination Disease progression disease severity doubling EGFR ELISA females ferritin FIVE Hospital admission hyperinflammation IMPROVE In-hospital interleukin interleukin-6 International Lactate lactate dehydrogenase LDH Linear model male marker median age observational study outcome parameter patients patients hospitalized plasma suPAR predict primary outcome measure procalcitonin progression risk stratification scale serum albumin serum lactate severity severity of COVID-19 significantly significantly lower suPAR survival survivor Treatment WHO WHO Clinical Progression Scale WHO-CPS [DOI] 10.1111/eci.13794 PMC 바로가기 [Article Type] Observational Study
Peptide Binder with High-Affinity for the SARS-CoV-2 Spike Receptor-Binding DomainSARS-CoV-2 스파이크 수용체 결합 도메인에 대한 고친화성을 갖는 펩티드 결합제Article Published on 2022-06-292022-09-11 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity peptide albumin antigen detection assembly binder binding binding affinity Biomarker Biomarkers bovine bovine serum albumin Characteristics coronavirus Delta diagnostics dissociation Dissociation constant early diagnosis exhibited fluctuation Gamma gold Gold nanoparticle high affinity Human serum albumin identify independent Interaction interface Lambda mutant omicron Omicron variants peptide phage Rapid rapid detection method RBD Receptor-binding domain recombinants respiratory SARS-CoV-2 SARS-CoV-2 spike protein selectivity sensor sequence serum albumin severe acute respiratory syndrome Coronavirus spike Spike protein the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1021/acsami.2c03707 PMC 바로가기 [Article Type] Article
Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France화이자/바이오엔텍 BNT162b2 코로나19 백신 3회 투여에 대한 반응: 프랑스 혈액투석 환자 집단에 대한 후향적 연구Observational Study Published on 2022-05-182022-09-12 Journal: BMC Nephrology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Anti-spike blood sample BNT162b2 body mass index booster Clinical practice Cohort Comirnaty coronavirus disease COVID-19 defined dialysis dose Factor France French Haemodialysis humoral humoral immune response identify IgG Immunoglobulin injection Injections kidney mortality rate mRNA vaccine National non-responder of BNT162b2 Patient patients performed Pfizer/BioNTech receive Registered remained Responder response retrospective Retrospective study SARS-CoV-2 serological serum albumin significantly significantly higher study population the mean the median titre U/mL Vaccine vaccine doses venous [DOI] 10.1186/s12882-022-02751-5 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases당화 혈청 알부민의 SARS-CoV-2 스파이크 단백질 결합-COVID-19 임상 증후군의 발병에 대한 잠재적 역할 및 당뇨병 전단계/2형 당뇨병 및 대사 질환이 있는 개인에 대한 편견Article Published on 2022-04-082022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] acute respiratory distress albumin analysed Anti-nucleocapsid antibodies Anti-spike anti-spike and anti-nucleocapsid antibodies antibody atherosclerotic Bacteria Bia binding capture clinical Complete convalescent convalescent plasma COVID-19 Diabetic disease end product explain flight form fusion glycated albumin high affinity Human serum albumin immune evasion immune response immunoglobulins individual mass spectrometry metabolic metabolic disease molecular feature molecular features nucleocapsid nucleocapsid protein Nucleocapsid proteins pathogenic pathology Patient plasma protein plasma proteins Potential pre-fusion preference respiratory distress role SARS-CoV-2 SARS-COV-2 infection semi-automated magnetic rack serum albumin Serum protein serum proteins severity spike Spike protein the spike protein virus viruses [DOI] 10.3390/ijms23084126 PMC 바로가기 [Article Type] Article
COVID-19 Infection in Kidney Transplant Recipients: A Single Center ExperienceResearch article Published on 2022-04-012022-10-05 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Admission age baseline C-reactive protein (CRP calculated can be used center Clinical characteristics Concentration conditions COVID-19 COVID-19 illness COVID-19 infection COVID-19 patients creatinine Critical demographics died evaluated exhibited experience Favipiravir ferritin high risk hospital Hospitalization Hospitalized Immunosuppression immunosuppressive kidney transplant recipient laboratory data Laboratory test LDH male marker Mortality Neutrophil-to-lymphocyte ratio NLR outcome Patient patients patients with COVID-19 PCR-positive Pneumonia Predictive prognostic recipient renal Result retrospective serum albumin survival survived the mean the patient therapy Transplant treated Treatment were recorded with COVID-19 [DOI] 10.1016/j.transproceed.2022.04.014 [Article Type] Research article
Decline of Humoral Responses 6 Months after Vaccination with BNT162b2 (Pfizer–BioNTech) in Patients on HemodialysisArticle Published on 2022-02-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence analyzed anti-SARS-CoV-2 IgG antibody association binding binding antibody BNT162b2 chemiluminescent immunoassay Chronic kidney disease CLIA COVID-19 Decline declined dose first vaccination Hemodialysis humoral immune response Humoral response identify immune response infected with SARS-CoV-2 median Month mRNA vaccines multivariable naïve Neutralizing activity Neutralizing antibodies Neutralizing antibody titer Patient Pfizer–BioNTech receiving Regression model response risk risk factor SARS-CoV-2 SARS-CoV-2 IgG Seroconversion seroconversion rate serum albumin spike glycoprotein vaccination vaccination schedule vaccine response vanishing was tested was used were measured wild-type virus [DOI] 10.3390/vaccines10020327 PMC 바로가기 [Article Type] Article
Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment키토산으로 코팅된 실리마린/커큐민 로딩 알부민 나노입자는 올레산 유발 폐 손상 및 시험관 내 COVID-19 실험에서 항염증 및 항 COVID-19 특성을 관찰하는 점막 흡입성 전달 시스템Article Published on 2022-02-152022-09-11 Journal: International journal of biological macromolecules [Category] 비임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome albumin alveolar Anti-inflammatory anti-viral activity assembly bovine bovine serum albumin BSA C-reactive protein can be used candidate chitosan coated coronavirus COVID-19 edema Efficacy ENhance experiment Health health problem hyaline membrane hyaline membranes hyperplasia identify in vitro infected patient infected patients Inflammation inflammatory process interleukin interleukin-6 Lung injury lung lesion lung lesions moment Mucoadhesive. oleic acid overcome Pneumonia Polymer Protein reduction in respiratory respiratory distress Respiratory distress syndrome septal serum albumin silymarin syndrome treated Treatment treatment of COVID-19 triggered virus [DOI] 10.1016/j.ijbiomac.2021.12.073 PMC 바로가기 [Article Type] Article
Predicting Severe Disease and Critical Illness on Initial Diagnosis of COVID-19: Simple Triage ToolsMedicine Published on 2022-02-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI Abu Admission age Analysis AUC calculator calibration characteristic clinician Cohort conducted country COVID-19 Critical Critical illness develop diagnosed with COVID-19 discharge discrimination Disease progression examined Factor help hospital illness independent initial Isolation Kidney function Laboratory test LDH multivariate logistic regression non-severe patient Patient Prediction model Predictive Predictive model predictive models predictor Prognosis progression Public rationale Result risk serum serum albumin serum lactate severe disease simple symptomatic patient Triage United Arab Emirate validation cohort was used were assessed were recorded were used [DOI] 10.3389/fmed.2022.817549 PMC 바로가기 [Article Type] Medicine