Single-nucleotide polymorphisms – Page 2 – Communicable Diseases Research

Permethrin resistance in Aedes aegypti : Genomic variants that confer knockdown resistance, recovery, and death

Aedes Aegypti의 퍼메 트린 저항 : 녹다운 저항, 회복 및 사망을 부여하는 게놈 변이체

Research Article

Published on 2021-06-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study

교육 성취는 유럽 인구의 COVID-19 심각성 위험 감소: 2표본 멘델식 무작위 배정 연구

Public Health

Published on 2021-06-032022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 95% confidence interval Analysis approach association attainment condition COVID-19 COVID-19 Host Genetics Initiative COVID-19 severity data set data sets decrease educational attainment epidemiological European European population Evidence evidence of Genetic genetic association Genome-wide association studies Genome-wide association study GWAS GWASs increase in initiative instrumental variable instrumental variables investigated lower risk measure mechanism mechanisms mendelian randomization MR study observational studies observational study Odds ratio outcome participant physical physical conditions polymorphism reported risk risk of COVID-19 SARS-CoV-2 Science Sensitivity analyses sensitivity analysis severity severity of COVID-19 significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs socioeconomic status Standard deviation was obtained was performed years of schooling
[DOI] 10.3389/fpubh.2021.673451 PMC 바로가기 [Article Type] Public Health

Genomic Signatures of SARS-CoV-2 Associated with Patient Mortality

환자 사망률과 관련된 SARS-CoV-2의 게놈 서명

Article

Published on 2021-02-022022-09-10
Journal: Viruses [Category] MERS, 변종, 유전자 메커니즘,

[키워드] age Analysis association Care Characteristics clade clinical outcomes Cohort coronavirus COVID-19 COVID-19 disease COVID-19 disease severity disease severity Factor finding functional Generalized linear model Genome genomic variant GLM IMPROVE International mechanism Mortality mortality rates Multiple Pathogenesis Patient patient age patient mortality Phylogenetic analysis polymorphism Prognosis remained sample collection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences Sex signature significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs target targets tested the SARS-CoV-2 genome validation cohort
[DOI] 10.3390/v13020227 PMC 바로가기 [Article Type] Article

Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro

인구 특이적 ACE2 단일 뉴클레오티드 다형성은 시험관 내 SARS-CoV-2 감염성에 제한적인 영향을 미칩니다

Communication

Published on 2021-01-062022-09-10
Journal: Viruses [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis analyzed angiotensin angiotensin-converting enzyme 2 causative agent cell entry coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Efficiency eight enzyme except for host gene host genes human populations Impact in vitro indicated Infectivity Interaction Limited molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation nonsense mutation performed polymorphism Population receptor Receptor binding reduced respiratory responsible SARS-2-S SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single-nucleotide Single-nucleotide polymorphisms SNP SNPs Spike protein susceptibility the SARS-CoV-2 validation study Viral viral cell viral cell entry
[DOI] 10.3390/v13010067 PMC 바로가기 [Article Type] Communication

Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy

COVID-19 치료의 잠재적 표적인 TMPRSS2 유전자의 구조적 다양성, 발현 프로필 및 약리학적 특성

Article

Published on 2020-12-252022-09-10
Journal: Genes [Category] MERS, SARS, 변종, 치료기술, 치료제,

[키워드] ACE2 acetaminophen acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar cell alveolar cells Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asian Basigin BSG co-expressed copy number copy number variant coronavirus COVID-19 COVID-19 therapy Curcumin distribution downregulate drug enzyme European populations ExoN expression expression levels frequencies Frequency genome-wide data human cells human population human populations Interaction interactions involved lung microRNA MicroRNAs Missense mutation Paracetamol pharmacotranscriptomics Polymorphisms Population Potential predicted priming profile profiles property Prostate cancer Protein ranged receptor regulate Regulation respiratory respiratory tract cells SARS-CoV-2 SARS-CoV-2 cell Serine serine 2 serine protease severe acute respiratory syndrome Coronavirus significantly higher Single-cell RNA sequencing single-nucleotide Single-nucleotide polymorphisms SNV target therapy tissue-specific expression TMPRSS2 Variability
[DOI] 10.3390/genes12010019 PMC 바로가기 [Article Type] Article

Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity

무배양 게놈 전체 유전자좌 서열 유형 지정(GLST)은 트리파노소마 크루지 분산 및 감염 복잡성에 대한 새로운 관점을 제공합니다.

Research Article

Published on 2020-12-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] agarose gel alternate allele frequency amplification amplify analyzed approach biases capture capture method Cell Chagas disease Chain Reaction city clone Co-infection collected Complete complex correlation correlations Culture detect dispersal distribution DNA Ecuador epidemiological epidemiological surveillance evaluate Ex vivo flexible frequency distributions generate Genetic Genetic polymorphism Genetic variation Genome genomes genotyping hotspot identify infecting Infection infection source Infectious disease Infectious diseases information intestinal involved library limitation lineages locus marker metagenomic minimum parasite parasites pathogen Pathogenic microorganisms Perspective polymerase chain polymerase chain reaction polymerase chain reactions polymorphism powerful tool primer principle provide purification representing Research Result sequence Sequencing single-nucleotide Single-nucleotide polymorphisms SNP Spectrum Strains subsequent subset Surveillance target target pathogen Trypanosoma Trypanosoma cruzi vector Venezuela
[DOI] 10.1371/journal.pgen.1009170 PMC 바로가기 [Article Type] Research Article

Identification of biological correlates associated with respiratory failure in COVID-19

COVID-19에서 호흡 부전과 관련된 생물학적 상관 관계 식별

Research Article

Published on 2020-12-112022-09-10
Journal: BMC Medical Genomics [Category] MERS, SARS, 유전자 메커니즘,

[키워드] analyses Analysis analyzed bioinformatics biological processe Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients curated Cutoff database determine Diseases downloaded epithelial explain false discovery rate Gene ontology Gene ontology analysis gene product Genes Genome-wide association study global public health GWAS identification implicated information input International Italy list list of gene loci mapped Ontology P -value p -values participant patients with COVID-19 polymorphism PPI protein-protein interaction recruited Respiratory failure Result risk SARS-CoV-2 single-nucleotide Single-nucleotide polymorphisms SNPs Spain unique genes was performed wound healing
[DOI] 10.1186/s12920-020-00839-1 PMC 바로가기 [Article Type] Research Article

Single nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India

인도의 고발병 지역에서 레프로마의 초점 전파를 나타내는 마이코박테리움 레프라에의 단일 염기 다형성 유형화

journal-article

Published on 2013-11-012024-08-01
Journal: Clinical Microbiology and Infection [Category] 한센병,

[키워드] Delhi Mycobacterium leprae Purulia Single-nucleotide polymorphisms Transmission
[DOI] 10.1111/1469-0691.12125 [Article Type] journal-article

Genetic variants associated with severe pneumonia in A/H1N1 influenza infection

Article

Published on 2013-10-292023-06-09
Journal: The European Respiratory Journal [Category] Fulltext, 신종인플루엔자,

[키워드] A/H1N1 genetic susceptibility Influenza Mexicans Single-nucleotide polymorphisms Viral pneumonia
[DOI] 10.1183/09031936.00020611 PMC 바로가기 [Article Type] Article