Single-nucleotide polymorphisms – Communicable Diseases Research

Genome-wide association study of SARS-CoV-2 infection in Chinese population

중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구

Article

Published on 2022-09-012022-09-11
Journal: European Journal of Clinical Microbiology & Infect
[Category] MERS, SARS, 변종, 진단,

SARS-CoV-2’s high rate of genetic mutation under immune selective pressure: from oropharyngeal B.1.1.7 to intrapulmonary B.1.533 in a vaccinated patient

면역 선택 압력 하에서 SARS-CoV-2의 높은 유전 돌연변이 비율: 백신 접종 환자의 구강인두 B.1.1.7에서 폐내 B.1.533으로

Case Reports

Published on 2022-05-012022-09-11
Journal: International Journal of Infectious Diseases
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] affected analyzed B.1.1.7 B.1.1.7 lineage bioinformatic analysis Case report collected complex COVID-19 dose Genetic high mutation rate immune Intra-Host Mutations intrapulmonary LAMP Lineage lineages lung Mutation mutation rate nasal swabs nasopharyngeal nasopharyngeal sample Nasopharyngeal samples next generation sequencing NGS observation Oropharyngeal Patient PCR polymorphism positive Post-vaccine Post-vaccine. Postmortem reverse transcription RT-LAMP SARS-CoV-2 selective single-nucleotide Single-nucleotide polymorphisms SNPs suggested survival tested the disease to define vaccination Viral Viral RNA viral RNAs virus
[DOI] 10.1016/j.ijid.2022.02.044 PMC 바로가기 [Article Type] Case Reports

The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

인터페론 람다 3과 4 유전자 단일-뉴클레오티드 다형성 사이의 연관성과 COVID-19 환자의 회복

Research

Published on 2021-11-142022-09-10
Journal: Virology Journal
[Category] MERS, SARS, 치료제,

[키워드] 25-hydroxyvitamin D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 association C-reactive protein caused clinical parameter Clinical parameters coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infection COVID-19 patient CRP disease disease susceptibility elevated erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluate Factor Frequency Genetic genetic factors Genotype genotyped Host IFNL3 IFNL4 include Infection Interferon lambda Interferon lambda 3 Interferon lambda 4 LDL Logistic regression analysis low-density Low-density lipoprotein multivariate multivariate logistic regression analysis nonsurvivors pandemic Pathogenesis patients PCR polymerase chain polymerase chain reaction polymorphism respiratory Result SARS-CoV-2 SARS-CoV-2 positive patient sedimentation rate Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severity of COVID-19 shown significantly higher single-nucleotide Single-nucleotide polymorphisms SNP SNPs survivor susceptibility Viral Viral load
[DOI] 10.1186/s12985-021-01692-z PMC 바로가기 [Article Type] Research

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

UAE 거주자 사이의 비타민 D 대사 경로의 유전적 변이와 COVID-19의 심각성 간의 연관성

Article

Published on 2021-10-202022-09-10
Journal: Nutrients
[Category] MERS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] 25-hydroxyvitamin D affected association Cell COVID-19 COVID-19 severity Critical CYP2R1 deficiency Effect Factor genetic determinant genetic determinants genetic variants Genetic variation Genetic variations genotype data genotypes hospital Human immune system implicated Infection investigated involved mechanism mechanism of action metabolism NADSYN1 outcomes Patient patients with SARS-CoV-2 polymorphism Population potential risk Research resident SARS-CoV-2 SARS-COV-2 infection serum serum 25-hydroxyvitamin D severe COVID-19 severity of COVID-19 single-nucleotide Single-nucleotide polymorphisms Spread two groups UAE United Arab Emirate United Arab Emirates vaccination variant VDR Viral viral infection Vitamin D vitamin D deficiency Vitamin D Metabolism Vitamin D status
[DOI] 10.3390/nu13113680 PMC 바로가기 [Article Type] Article

A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

CTCF 결합을 방해하는 인터루킨-6의 저생산 일배체형은 심각한 COVID-19를 예방합니다

Research Article

Published on 2021-10-122022-09-10
Journal: mBio
[Category] MERS, 변종,

[키워드] 95% confidence interval allele Analysis antisense Asia Asian bidirectional transcription carrier carriers Chinese conserved correlated COVID-19 COVID-19 patient COVID-19 severity CTCF defined Disease progression disturbance element Endemic enhancer expression functional genetic polymorphisms Genotype Haplotype Human humans hyperinflammation IL-6 IL-6 blockade IL-6 expression induce Inflammatory responses inflammatory stimuli interleukin-6 intronic SNP intronic SNPs loci locus long noncoding RNA lower risk Mild Neanderthal Odds ratio outcome patients polymorphism Polymorphisms promoter Protective Quantitative reduced severe symptom severe symptoms severity significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs T allele therapy transcribed Variability variant Viral viral infection with COVID-19
[DOI] 10.1128/mBio.01372-21 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy

항체 단독 요법을 받은 면역 저하 환자의 SARS-CoV-2 변이체

Expedited

Published on 2021-10-012022-09-10
Journal: Emerging Infectious Diseases
[Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bamlanivimab blood sample Blood samples compartmentalization coronavirus coronavirus disease Coronaviruses COVID-19 Evolution Immunocompromised Immunotherapy melting curve analysis monoclonal antibody monotherapy Mutation nasopharyngeal polymorphism populations Rapid Receptor binding domain respiratory respiratory infections SARS-CoV-2 Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-nucleotide Single-nucleotide polymorphisms Spike receptor binding domain variants Viral viral evolution viruses whole-genome sequencing zoonoses
[DOI] 10.3201/eid2710.211509 PMC 바로가기 [Article Type] Expedited

Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic

SARS-CoV-2 대유행에서 계통 간 재조합체의 생성 및 전달

Article

Published on 2021-09-302022-09-11
Journal: Cell
[Category] MERS, SARS, 변종,

[키워드] (alpha Abstract Alpha B.1.1.7 B.1.1.7 variant breakpoint cellular characteristic circulating Cluster community transmission complement coronavirus Course Deletion deletions eight Estimated events Evidence Evolution Generation Genetic variation Genome Genomic epidemiology genomic location Genomics identify independent instances lack lead mutations onward transmission pandemic parental polymorphism provide recombinant recombinants Recombination Replication sampling SARS-CoV-2 SARS-CoV-2 recombination SARS-CoV-2 virus sequenced single-nucleotide Single-nucleotide polymorphisms spike gene the SARS-CoV-2 Transmission United Kingdom variant variants virus virus viruses
[DOI] 10.1016/j.cell.2021.08.014 PMC 바로가기 [Article Type] Article

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma

비호지킨 림프종을 가진 면역저하 환자에서 SARS-CoV-2의 장기적 진화

Research Article

Published on 2021-07-282022-09-10
Journal: mSphere
[Category] MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] A222V accelerated accumulated accumulation adaptive Administered alterations Amino acid amino acid change Antigen Community Convalescent plasma therapy convergent evolution COVID-19 Deletion epidemiological evaluate Evolution Evolution of SARS-CoV-2 Genome Genome sequencing identify immune evasion Immune status Immunocompromised Immunocompromised host immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunosuppressive immunosuppressive therapy infected individuals Infection long-term infection mitigate MONITOR Mutation mutations Non-Hodgkin Lymphoma occurred pandemic virus pathway Patient polymorphism Protein recent reported risk SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 infections scenario shown single-nucleotide Single-nucleotide polymorphisms SNPs spike Spike protein Support survival the SARS-CoV-2 therapy Transmission Trigger variant variants variants of concern Viral Viral genome sequencing virus virus spike protein was performed
[DOI] 10.1128/mSphere.00244-21 PMC 바로가기 [Article Type] Research Article

Permethrin resistance in Aedes aegypti : Genomic variants that confer knockdown resistance, recovery, and death

Aedes Aegypti의 퍼메 트린 저항 : 녹다운 저항, 회복 및 사망을 부여하는 게놈 변이체

Research Article

Published on 2021-06-172022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Aede Amino acid amino acid substitution amino acid substitutions association calcium calcium channel Chikungunya comparison Concentration cuticle dead death Dengue dependent on detoxification detoxification enzymes develop directional disease disease control disease outbreaks effective Frequency functional Genes genetic background Genome genomic genomic variant genomic variants heterogeneous population identify IMPROVE individual information insecticide insecticides knockdown knockdown resistance lead list marker mechanism metabolism moderate Mosquito Mutation occur Outbreaks penetration performed Permethrin phenotype phenotypic polymorphism Population populations Prevent proportion protein coding genes Proteins provide public health pyrethroid Pyrethroids reduce Region resistance mechanism resistance mechanisms response sequenced single-nucleotide Single-nucleotide polymorphisms SNPs sodium sodium channel suppress suppression survival tested transmitted Treatment Vaccine variant vector control viral disease Viral diseases voltage voltage-gated sodium channel Zika Zika viruses
[DOI] 10.1371/journal.pgen.1009606 PMC 바로가기 [Article Type] Research Article

Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study

교육 성취는 유럽 인구의 COVID-19 심각성 위험 감소: 2표본 멘델식 무작위 배정 연구

Public Health

Published on 2021-06-032022-09-11
Journal: Frontiers in Public Health
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] 95% confidence interval Analysis approach association attainment condition COVID-19 COVID-19 Host Genetics Initiative COVID-19 severity data set data sets decrease educational attainment epidemiological European European population Evidence evidence of Genetic genetic association Genome-wide association studies Genome-wide association study GWAS GWASs increase in initiative instrumental variable instrumental variables investigated lower risk measure mechanism mechanisms mendelian randomization MR study observational studies observational study Odds ratio outcome participant physical physical conditions polymorphism reported risk risk of COVID-19 SARS-CoV-2 Science Sensitivity analyses sensitivity analysis severity severity of COVID-19 significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs socioeconomic status Standard deviation was obtained was performed years of schooling
[DOI] 10.3389/fpubh.2021.673451 PMC 바로가기 [Article Type] Public Health