A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaquesArticle Published on 2022-10-052022-11-15 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Adenovirus Administered administration Affect approach cellular immunity coronavirus coronavirus disease COVID-19 COVID-19 vaccine cynomolgus macaques evaluate Human humoral mAb mAbs macaque monoclonal antibody monoclonal antibody combination not affect offer required SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant spike glycoprotein the vaccine Treatment vaccinated individuals vaccination rates Vaccine viral vector-based waning immunity [DOI] 10.1126/scitranslmed.abo6160 PMC 바로가기
Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 responseArticle Published on 2022-10-012023-07-09 Journal: Immunology [Category] COVID19(2023년), [키워드] chemokine Cytokine storm hyperimmunity. LPS osteopontin SARS-CoV-2 spike glycoprotein Th1 response [DOI] 10.1111/imm.13524 PMC 바로가기
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein spike glycoprotein. stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanismsReview article Published on 2022-10-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] ACE2angiotensin converting enzyme AMP-activated protein kinase AMPKAMP-activated protein kinase angiotensin converting enzyme antigen-presenting cells antioxidant APCantigen-presenting cells c‐Jun N‐terminal kinase clinical trial Complication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 database Direct Diseases distress Effect ERKextracellular signal-regulated kinase Evidence exhibited extracellular signal-regulated kinase Factor HBVHepatitis B virus HCVHepatitis C virus Hepatitis B virus hepatitis C virus HIVhuman immunodeficiency virus Human immunodeficiency virus IFNγinterferon γ ILInterleukin immune system Immune system dysfunction Impact indicate Inflammation Inflammatory response interferon γ interleukin involved JAKc‐Jun N‐terminal kinase Like MAPKmitogen-activated protein kinase mechanism MERS-CoVmiddle east respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus mitogen-activated protein kinase neutrophil-lymphocyte-ratio NF-κBnuclear factor kappa B nitric oxide NLRneutrophil-lymphocyte-ratio NONitric Oxide Nrf2nuclear factor erythroid 2–related factor 2 nuclear factor erythroid 2–related factor 2 nuclear factor kappa B oxidative stress pandemic pathogenesis of COVID-19 protease reactive oxygen species reducing Research ROSreactive oxygen species SARS-CoV 2severe acute respiratory syndrome coronavirus SARS-CoV-2 SARSSevere Acute Respiratory Syndrome Science searched Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus signal transducer and activation of transcription silibinin spike glycoprotein STATsignal transducer and activation of transcription T helper 1 target protein TGF-βtransforming growth factor beta Th1T helper 1 therapeutic benefits therapeutic effect therapy TLR-4toll like receptor 4 toll like receptor 4 transforming growth factor beta treating COVID-19 viral replication Web of Science WHOWorld Health Organization World Health Organization [DOI] 10.1016/j.biopha.2022.113593 [Article Type] Review article
Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2Article Published on 2022-09-302022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] ACE2 ACE2 affinity ACE2 receptor Affect arising BA.4 BA.5 COVID-19 domain enzyme glycoprotein Human immunogenic include infect influence Interaction multiple mutation mutated omicron other variants plasma RBD receptor SARS-CoV-2 shown significantly increased spike spike glycoprotein temperature the Spike translate Transmission vaccinated individuals variant Variant of concern. Viral transmission VoC [DOI] 10.3390/v14102178 PMC 바로가기
Engineering recombinantly expressed lectin-based antiviral agentsArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome antiviral agent binding binding affinity binding mechanism binding site carbohydrate carbohydrate-binding agent Coronavirus-2 cyanovirin-N Ebola Engineering expressed high-mannose HIV Human immunodeficiency virus infection with influenza inhibitory Interaction investigated isothermal titration calorimetry ITC lectin mechanism mutated N-linked glycan neutralization ability neutralizing antibody Nostoc oligosaccharides peptide polar interactions Protein RBD residue SARS-CoV-2 SARS-CoV-2 glycoprotein spike spike glycoprotein Spike protein SPR tested transfer variant viral membrane viral spikes virus virus virus. was measured were used [DOI] 10.3389/fcimb.2022.990875 PMC 바로가기
Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensorsArticle Published on 2022-09-152022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody antibody fragment antigen detection binding Clinical treatment clone coronavirus demonstrated diagnose effective Fab fluorescent Health help Human monoclonal antibody human SARS-CoV-2 IgG neutralize neutralizing antibody outbreak Prevent public health S protein S1 domain SARS-CoV-2 selected spike glycoprotein spread of COVID-19 viral infection viral infections virus detection [DOI] 10.1038/s41598-022-19699-z PMC 바로가기
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster modelsArticle Published on 2022-09-092022-11-15 Journal: Communications Biology [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-RBD anti-S2 anti-SARS-CoV-2 antibody fragment arsenal candidate characterized conserved cross-reactivity demonstrated detectable Efficacy epitope feasibility IgG in vitro in vivo intrinsic mAb magnitude nanobodies nanobody neutralization offer provide reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown specificity spike glycoprotein therapeutic thermodynamic viral burden [DOI] 10.1038/s42003-022-03866-z PMC 바로가기
Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screenArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 acute respiratory syndrome administration affecting angiotensin-converting enzyme 2 Antiviral association benefit bifonazole bind binding blocking agent compounds coronavirus coronavirus disease COVID-19 drug Drug discovery effective food High-throughput screening identification infect cell inhibitor interfere K18-hACE2 mice K353 live SARS-CoV-2 nanoluciferase bioreporter. omicron Prevent RBD RBD-ACE2 receptor Receptor binding domain reduce Replication residue SARS-CoV-2 spike glycoprotein spike-pseudotyped virus target receptor the RBD treat variants of concern vesicular stomatitis virus VoC VOCs [DOI] 10.1016/j.ymthe.2022.04.025 PMC 바로가기
Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine modelArticle Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 진단, [키워드] BALB/c mice cellular change control group coronavirus dose group immunogen immunogenic immunogenicity Inflammatory inoculated mice murine model Protein Public public health RBD risk Safe SARS-CoV-2 Seroconversion shown spike spike glycoprotein subunit Surveillance the RBD vaccination. Vaccine vaccine candidate variants variants of concern virus were used [DOI] 10.1016/j.tmaid.2022.102427 PMC 바로가기