SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications Research Published on 2022-03-312022-10-05 Journal: Scientific Data [Category] 유전자 메커니즘, [키워드] Activation Analysis article Biology condition curated database dataset described disease driving effective experiment groups Inconclusive information inhibitor inhibitory inhibitory compound inhibitory compounds Potential treatment progression Protein provide Research researchers STAT Transcription [DOI] 10.1038/s41597-022-01243-3 [Article Type] Research
Performance evaluation of Elecsys SARS-CoV-2 Antigen immunoassay for diagnostic of COVID-19코로나19 진단을 위한 Elecsys SARS-CoV-2 항원 면역분석의 성능 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aims alternative Antigen antigen detection antigen tests Chain Reaction complement coronavirus COVID-19 cross Cross reactivity cross-reactivity Cycle threshold value diagnostic Elecsy Elecsys evaluate HKU1 identify immunoassay individual Infection Influenza Influenza virus Nasopharyngeal swab nasopharyngeal swabs Negative predictive value NPV OC43 other respiratory virus Other respiratory viruses parainfluenza virus performance point of care polymerase chain reaction positive PPV Predictive value Randomly ranged reduce reference test respiratory viruses reverse transcription Reverse transcription-polymerase chain reaction rhinovirus Roche Diagnostics RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigen tests SARS-CoV-2 transmission selected sensitivity severe acute respiratory syndrome Coronavirus specificity STAT Symptoms [DOI] 10.1002/jmv.27412 PMC 바로가기 [Article Type] Article
Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach류마티스학에서의 Janus kinase-targeting therapy: 메커니즘 기반 접근Review Published on 2022-03-012022-09-12 Journal: Nature reviews. Rheumatology [Category] MERS, SARS, 진단, [키워드] activate Activation adaptive addition allergic approach atopic dermatitis Autoimmune Autoimmune disease autoreactive T cell B cells cytokine Cytokine storm development Diseases disorders downstream effective glucocorticoid immune Immune-mediated inflammatory diseases Immunity Immunosuppressant implicated Inflammatory bowel disease Inflammatory diseases inhibitory Innate immunity involved Jak JAK inhibitor jak inhibitors JAK-STAT pathway janus Janus kinase multiple cytokine non-specific outcome pathology positive profiles Protein receptors rheumatoid arthritis selective Seven Signal transduction spondyloarthritis STAT suppress systemic lupus erythematosus therapy Transcription transcription factor Treatment [DOI] 10.1038/s41584-021-00726-8 PMC 바로가기 [Article Type] Review
Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signalingJAK2/STAT3 신호 전달 억제를 통한 코로나19 사이토카인 폭풍 진정Review Published on 2022-02-012022-09-11 Journal: Drug discovery today [Category] 변종, 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral treatment caused clinically evaluated coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic cytokine release Cytokine storm drug Drug discovery effective antiviral treatment herd immunity hyper-inflammation Immunity JAK inhibitor jak inhibitors JAK/STAT signaling JAK2/STAT3 life-threatening lung Lungs New outbreak Pathways Patient reached reported respiratory distress Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling STAT syndrome the cytokine storm tissue damage Treatment Vaccines viral variant Viral variants [DOI] 10.1016/j.drudis.2021.10.016 PMC 바로가기 [Article Type] Review
Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?Pharmacology Published on 2022-01-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” ACE ACE2 alkaloids Ang II Anti-inflammatory antioxidant effects ARDS Asthma biological significance bulbus fritillariae cirrhosae Characteristics Chinese COPD COVID-19 Degradation drug Drug discovery exhibit explained Inflammatory response Intervention involved lung cancer Lung disease MAPK signaling mechanism Medicine molecular NF-κB Pathways Potential produced pulmonary tuberculosis RAS regulate renin-angiotensin system Research respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-COV-2 infection signaling pathway signaling pathways STAT targets therapeutic therapeutic drug therapeutic potential Treatment [DOI] 10.3389/fphar.2021.784335 PMC 바로가기 [Article Type] Pharmacology
Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19생물 정보학 및 실리코 내 발견은 결장 직장암 및 Covid-19에 대한 바이오 카닌 A의 의학적 특징과 약리학 적 목표를 보여줍니다.Research Article Published on 2021-12-232022-09-01 Journal: Bioengineered [Category] 유전자 메커니즘, 진단, 치료제, [키워드] addition Analysis applied approach biochanin a bioinformatics biological function Cancer patients CCND1 cell proliferation Chronic diseases Clinical use Cluster Colorectal cancer combination therapy COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cytokine receptor demonstrated Effect effective EGFR feature functional gene cluster IL1A IL2 IL6R immune response in-silico Interaction interleukin-6 involved JAK-STAT signaling pathway lack Mortality network pharmacology pathology Pathway analysis Patient patients pharmaceutical target pharmacological target PI3K PPARG receptor Side effect STAT therapeutic option Treatment [DOI] 10.1080/21655979.2021.2005876 PMC 바로가기 [Article Type] Research Article
Evaluation of Sensitivity and Specificity of Three Commercial Real-Time Quantitative Polymerase Chain Reaction Kits for Detecting SARS-CoV-2 in BangladeshPathology Published on 2021-12-222022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% confidence interval Accuracy acute respiratory syndrome applied chain China coronavirus coronavirus disease COVID-19 COVID-19 infection cycle threshold detect determine diagnostic Diagnostic performance facilitated Genes indicated Isolation Italy manifested nucleic acid ORF1ab ORF1ab gene pandemic parameter Patient PCR performed polymerase chain predominant public health crisis Quantitative RdRp gene reaction receive required Research Result RNA extraction Roche RT-qPCR SARS-CoV-2 sensitivity sentinel specificity Spread STAT Switzerland variant [DOI] 10.7759/cureus.20627 PMC 바로가기 [Article Type] Pathology
Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster생물 정보학 분석은 COVID-19 관련 대상 포진의 메커니즘으로 증강된 인터루킨-17 신호 전달을 제안합니다Article Published on 2021-12-012022-09-11 Journal: Environmental science and pollution research inter [Category] 대상포진, 두창, 수두, 유전자 메커니즘, 홍역, [키워드] Analysis ApoE ARSA Bioinformatic blistering CCR2 CCR5 cell differentiation correlation COVID-19 CRP CXCL13 cytokine cytokine receptor distribution dorsal root ganglia DRB1 EGFR ESR1 Genetic GP2 Herpe herpes zoster herpetic neuralgia HLA-A HLA-B HLA-DRB1 IL-17 IL10 IL17A IL5 IL6 IL7 Increasing indicated Interaction interleukin-17 involved Jak-STAT mechanism pathophysiological mechanism raise raised Rash receptor resulting risk SARS-CoV-2 Signaling STAT STAT3 subset suggested TECTA Th17 THBS1 TNF varicella Varicella zoster virus virus Zoster [DOI] 10.1007/s11356-021-15567-x PMC 바로가기 [Article Type] Article
Increasing diagnostic possibilities using the geneLEAD VIII platform for detection of SARS-CoV-2SARS-CoV-2 검출을 위한 geneLEAD VIII 플랫폼을 사용한 진단 가능성 증가Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] absence addition blinded clinical sample clinical samples Complete Concordance coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold Diagnosis diagnostic diagnostic system diagnostic test E-gene geneLEAD. genomic sequence in vitro Increasing IVD Laboratory National Netherland Netherlands new virus PCR platform point-of-care positive Quality assurance Rapid Rapid diagnostic test reference standard reverse-transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 testing STAT tested [DOI] 10.1016/j.jviromet.2021.114291 PMC 바로가기 [Article Type] Article
Altered increase in STAT1 expression and phosphorylation in severe COVID‐19Clinical Trial Published on 2021-11-172022-10-04 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, [키워드] abnormality absence Altered antiviral defense mechanism baseline Biomarker CD14+ monocyte CD169 component correlated COVID‐19 COVID‐19 Cytokine storm downstream element expression flow cytometry IFN IFN signaling IFN‐γ Immune cell increase in induce interferon interferon pathway interferon signaling investigated IRF1 IRF9 ISRE JAK/STAT JAK/STAT signaling limit lower expression Mild mild cases monocyte Monocytes Patient PBMC Phosphorylation plasmablast Predictive pSTAT1 SARS‐CoV‐2 infection Severe case Severe infection severely infected patient Signaling STAT Stat1 STAT2 stimulated Stratification T cell target therapeutic target Transcription Transcriptional upregulation type I interferon upregulation [DOI] 10.1002/eji.202149575 PMC 바로가기 [Article Type] Clinical Trial