Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activationArticle Published on 2022-06-282023-07-09 Journal: Cell Reports [Category] COVID19(2023년), [키워드] CP: Immunology Cytokine variability IL-12p70 systems immunology TLR4 immune responses type I interferons [DOI] 10.1016/j.celrep.2022.110989 PMC 바로가기
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2변종별 백신 접종은 시스템 면역 반응을 유도하고 SARS-CoV-2에 대한 강력한 생체 내 보호Article Published on 2022-05-172022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] animal models antibody B and T lymphocytes B.1.351 B.1.617 B.1.617.2 BCR Beta Beta variant breakthrough infections caused CD8 T cell clonal expansions COVID-19 vaccine Delta delta variant Delta variants Efficacy Gene Expression generate immune cell population immune cell populations immune profiling immune response immune responses in vivo induce Lineage Lipid Lipid nanoparticle LNP-mRNA Lymphocytes mRNA mRNA vaccination mRNA vaccines neutralization neutralization activity offer reactive SARS-CoV-2 SARS-CoV-2 spikes single-cell single-cell profiling Single-cell transcriptomics systems immunology T cell T cell response T cell responses T cells T lymphocytes TCR These data vaccination Vaccine variant variant-specific COVID-19 vaccine. variants virus viruses widespread wild-type [DOI] 10.1016/j.xcrm.2022.100634 PMC 바로가기 [Article Type] Article
Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malariaArticle Published on 2022-04-192024-08-28 Journal: Cell Reports [Category] 말라리아, [키워드] antibodies CP: Immunology CP: Microbiology Gamma delta T cells Innate immunity malaria Monocytes omics data Plasmodium falciparum systems immunology Tolerance
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients조합 분석은 경증 COVID-19 환자에서 나중에 항바이러스 면역을 예측하는 고도로 조정된 초기 단계 면역 반응을 보여줍니다Article Published on 2022-03-292022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] Analysis antibody antibody levels Antibody Response antibody-secreting cell antibody-secreting cells antiviral immunity Arm Asymptomatic CD4 CD8 T cells cellular Cohort combinatorial analysis controls COVID-19 CXCL10 cytokine cytokine response dendritic cell Diagnosis dominant early-stage response expression feature Frequency functional hospitalized patient hospitalized patients immune immune cells immune reaction immune response immune responses immunology immunopathology Inclusion innate immune cell Innate immune cells interferon IP10 marker Mild mild COVID-19 patient mild COVID-19 patients mild patient mild patients non-hospitalized observé Patient PCR predict predict antibody levels Predictive remained response reveal SARS-CoV-2 severe COVID-19 systematic analysis systems immunology T cell T cells trajectory transient cytokine response. while [DOI] 10.1016/j.xcrm.2022.100600 PMC 바로가기 [Article Type] Article
Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New TherapiesArticle Published on 2021-12-012024-09-04 Journal: Trends in molecular medicine [Category] 대상포진, [키워드] patient heterogeneity Personalized medicine systemic lupus erythematosus systems immunology Therapies transcriptomics [DOI] 10.1016/j.molmed.2020.09.009 PMC 바로가기 [Article Type] Article
Predictive Markers of Immunogenicity and Efficacy for Human VaccinesReview Published on 2021-06-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adopted animal model applied approach coronavirus Data analysis develop Efficacy effort help high-throughput technologies Human human populations humans identifying immune immune signature Immunity immunogenicity in silico in vivo imaging increasingly machine learning malaria marker methodology Pandemics Pathogens preclinical models preclinical study Predictive predictive biomarkers Predictive model probe protective responses Research responses SARS-CoV-2 Systems biology systems immunology translational Tuberculosis unsupervised analyses vaccination Vaccination strategies Vaccine vaccine candidate vaccine signatures Vaccines Zika virus [DOI] 10.3390/vaccines9060579 PMC 바로가기 [Article Type] Review
Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across virusesArticle Published on 2021-04-132022-10-30 Journal: Immunity [Category] COVID-19, [키워드] Abstract accelerate age Analysis analyzed Bacterial infections blood transcriptome cells Chikungunya Cohort cohorts conserved conserved host response to viruses COVID-19 defined detrimental diagnostics disease severity Ebola global pandemic Hematopoiesis Host immune response host response host-directed therapy identify Immune cell IMPROVE Increased induce Infection Influenza interferon response Mild multi-cohort analysis outcome outcomes pan-virus analysis Patient profile Protective SARS-CoV-2 severity single-cell Single-cell RNA sequencing systems immunology trajectory transcriptome profile viral infection virus viruses [DOI] 10.1016/j.immuni.2021.03.002 PMC 바로가기 [Article Type] Article
Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum면역 변이 및 Plasmodium falciparum에 감염된 순진한 숙주에서의 var 유전자 전환 매핑Article Published on 2021-03-022024-08-08 Journal: eLife [Category] 말라리아, [키워드] falciparum malaria Human human immune variation Inflammation metabolomics P. falciparum systems immunology var gene switching [DOI] 10.7554/eLife.62800 PMC 바로가기
Increased IL‐10‐producing regulatory T cells are characteristic of severe cases of COVID‐19Original Article Published on 2020-11-132022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] Activation affected analysed Asymptomatic carriers characteristic clinical Community contribute coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 healthy individuals host–virus interaction Hypothesis identify IL‐10 immune response immunological immunology increase in Increased investigated Lineage lung lymphopenia New coronavirus objective open resource pandemic Patient patients Peripheral blood phenotype platform proportion Regulatory T cell regulatory T cells Research resource Result SARS‐CoV‐2 SARS‐CoV‐2 Severe case Spread systems immunology T regulatory cells T‐cell underlie Variation [DOI] 10.1002/cti2.1204 PMC 바로가기 [Article Type] Original Article