Type I interferon production elicits differential CD4+ T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudiArticle Published on 2022-01-012024-08-28 Journal: International Immunology [Category] 말라리아, [키워드] cytokine Immunological memory malaria Tfh Th1
Case Report: Clinical Management of a Patient With Metastatic Non-Small Cell Lung Cancer Newly Receiving Immune Checkpoint Inhibition During Symptomatic COVID-19증례 보고: 코로나19 증상이 있는 동안 면역 체크포인트 억제를 새로 받은 전이성 비소세포폐암 환자의 임상 관리Case Reports Published on 2021-12-202022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] activated ambulatory patient Analysis anti-cancer treatment anti-PD1 antiviral immunity blockade CD4 CD8 cellular change clinical Corticosteroid Course COVID-19 CT scan Effect feasible Follow-up healthy High-dose Hospitalized humoral immune response IgG immune checkpoint Immunotherapy inhibition initiated lesion lung cancer male malignancy management metastatic Neutralizing NSCLC Patient PD1 Pembrolizumab Pneumonia Pneumonitis presenting Radiographic SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection serum sustained symptomatic T cell Tfh the patient treatment initiation worsened [DOI] 10.3389/fimmu.2021.798276 PMC 바로가기 [Article Type] Case Reports
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별Article Published on 2021-12-062022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] activate activated T cell activated T cells activating Adaptive immunity Antigen booster CD4+ T cell CD4+ T cells Cell characterized circulating commensal bacteria conserved COVID-19 epitope Epitopes expand follicular healthy donors HLA identification mild COVID-19 patient mild symptoms Patient prevalent Protective protective antibodies SARS-CoV-2 epitopes SARS-CoV-2 S SARS-CoV-2 spike subset T cell T cells TCR TCRs Tfh Tfh cell Tfh cells the SARS-CoV-2 variants [DOI] 10.1084/jem.20211327 PMC 바로가기 [Article Type] Article
Imbalanced Immune Response of T-Cell and B-Cell Subsets in Patients with Moderate and Severe COVID-19중등도 및 중증 COVID-19 환자에서 T- 세포 및 B- 세포 서브 세트의 불균형 면역 반응Article Published on 2021-09-302022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] acute COVID-19 analyzed B cell B cells B-cell B-cell subsets both groups Ccr6 CD27 CD38 CD45 CD45RA Cell circulating COVID-19 COVID-19 patients CRP dysregulated enrolled flow cytometry follicular Frequency group healthy donor humoral immune response Imbalance imbalanced immune response immunological change immunological changes Infection memory minute moderate multicolor flow cytometry oxygen Oxygen therapy PaO Patient phenotype Phenotypes predominant qSOFA reduced respiratory rate response severe COVID-19 significantly skewed SpO2 subset T-cell subsets Tfh Th cells Th17 with COVID-19 [DOI] 10.3390/v13101966 PMC 바로가기 [Article Type] Article
Follicular Helper T Cells in the Immunopathogenesis of SARS-CoV-2 InfectionSARS-CoV-2 감염의 면역병인 발생에서 여포 도우미 T 세포Review Published on 2021-09-162022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody secretion B cell B cells caused Cell-mediated immunity cells contribute coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccines driving Effector mechanism Evidence feature follicular functional global pandemic helper highlight Immunity Immunopathogenesis Infection Infectious disease morbidity and mortality neutralizing antibody progression reaction regulated SARS-CoV-2 SARS-COV-2 infection suggested Tfh Tfh cell Tfh cells therapeutic strategy [DOI] 10.3389/fimmu.2021.731100 PMC 바로가기 [Article Type] Review
Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination항원 특이적 CD4 + T 세포의 신속한 유도는 SARS-CoV-2 mRNA 백신 접종에 대한 체액 및 세포 면역의 조정과 관련이 있습니다.Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 바이오마커, 진단, [키워드] Activation activation induced markers AIM Analysis booster vaccination CD4 CD8 Cell cellular immunity Clinical efficacy correlated first dose follicular healthy highlight humoral immune response immune responses immunological Immunological memory individual individuals Kinetics Last magnitude mRNA mRNA vaccination mRNA vaccine mRNA vaccines naïve subjects Neutralizing antibodies performed prime and boost priming question Rapid induction response SARS-CoV-2 second dose shown subject subjects T cell T cell response T cell responses T cells T follicular helper Tfh Th1 trajectory vaccination vaccine dose [DOI] 10.1016/j.immuni.2021.08.001 PMC 바로가기 [Article Type] Article
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.423 Published on 2021-08-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvanticity alum alum adjuvant antibodies antibody Antibody Response Antibody responses Antigen Blood bloodstream blunt CD4 Cell-mediated immunity coronavirus COVID-19 patients Efficacy Elastase ENhance epitope Epitopes follicular help identify IgA antibodies IgA antibody IL-1 Immunity immunization Immunoglobulin IMPROVE induce inhibition inhibitor injected innate response interleukin investigated lack magnitude mice mucosal mucosal immunity mucosal route mucosal secretion mucosal tissue mucosal tissues myeloid cells neutrophil Neutrophil elastase neutrophil elastase inhibitor Neutrophils pharmacological promote protective antibodies Protective antibody Protein Protein subunit protein-based vaccine recruitment regulate response responses SARS-CoV-2 SARS-CoV-2 spike protein sera Serine serine protease serum antibody serum IgG severe acute respiratory syndrome Coronavirus SIgA Significance Spike protein stimulate subunit Support suppression T cell T cell responses T helper Tfh Th1 Th2 the spike protein vaccination Vaccine Vaccines [DOI] 10.1073/pnas.2102435118 PMC 바로가기 [Article Type] 423
SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescenceSARS-COV-2- 특이 적 순환 T 여포 헬퍼 세포는 중화 항체와 관련이 있으며 조기 회복기 동안 증가합니다.Research Article Published on 2021-07-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단, 치료기술, 치료법, [키워드] addition Antibody neutralization Antigen approved assist Blood caused CD4 T cells CD4 T-cell Cell circulating contribute convalescence convalescent convalescent individuals coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 CXCR5 declined defined detectable examined follicular Frequency generate greater helper cells helping immune response immune responses individual Infection M protein magnitude majority median morbidity and mortality mounted N protein Neutralizing antibodies neutralizing antibody neutralizing antibody responses pandemic PD1 post-symptom onset PROTECT Protein response responses responses against robust S protein SARS-CoV-2 SARS-COV-2 infection specificity Spike protein structural protein structural proteins subset symptom onset T cells T cells) T follicular helper cells T-cell immunity T-cell Response T-cell responses Tfh the spike protein the strongest These cells These data Vaccine [DOI] 10.1371/journal.ppat.1009761 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaquesSARS-CoV-2는 붉은 털 원숭이에서 강력한 생식 중심 CD4 T 여포 도우미 세포 반응을 유도합니다Article Published on 2021-01-222022-09-10 Journal: Nature Communications [Category] 진단, 치료법, [키워드] Adaptive immunity Antibody Response Antibody responses Antiviral Blood CD4 Cell convalescent plasma COVID-19 follicular GC response GC responses generate Germinal center helper cell humoral induce induction Infectious diseases infused infusion lung lymph nodes Mild Monocytes Nucleocapsid proteins Peripheral blood plasma pro-inflammatory monocyte pro-inflammatory monocytes question receiving response rhesus rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serum IgG antibodies skewed stimulate Tfh Tfh cell Th1 the SARS-CoV-2 Viral viral infections Viral proteins [DOI] 10.1038/s41467-020-20642-x PMC 바로가기 [Article Type] Article
Screening and development of monoclonal antibodies for identification of ferret T follicular helper cellsArticle Published on 2021-01-212022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] animal model antibodies antibody assist Bcl6 Cell clone Critical cross-reactivity CXCR5 effective ferret ferrets follicular Follicular T-helper cells humans Humoral response identify immune system Infection Influenza Lymph node marker mice monoclonal antibodies monoclonal antibody murine pathogenicity PCR-based method reagents response SARS-CoV2 Screening single B cell Tfh Tfh cell Transmissibility Vaccine Vaccines viruses [DOI] 10.1038/s41598-021-81389-z PMC 바로가기 [Article Type] Article