Clinical decision analysis of elective delivery vs expectant management for pregnant individuals with COVID-19–related acute respiratory distress syndromeResearch article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome age Analysis cesarean delivery children clinical decision Clinical decision analysis comparable Complication Computer simulation COVID-19 Critical illness death Decision analysis determine Elective Evidence gestation hospital individual individuals iteration lack likelihood management Maternal Model Mortality mortality risk Neonatal Neonates neonatology obstetrics outcome outcomes parameter performed Pregnancy pregnant premature birth quantification risk sensitivity analysis severity spontaneous labor survival syndrome the mean utility Ventilated [DOI] 10.1016/j.ajogmf.2022.100697 [Article Type] Research article
Population-based screening in a municipality after a primary school outbreak of the SARS-CoV-2 Alpha variant, the Netherlands, December 2020-February 2021Article Published on 2022-10-272022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age Alpha Alpha variant Analysis caused children circulation Clinical symptoms confounders epidemiological link individual infected individual infected individuals Laboratory Lineage B.1.1.7 Netherlands not significantly different outbreak PCR Prevent public health measures questionnaire SAR SARS-CoV-2 SARS-CoV-2 variant School Schools secondary attack rate self-reported symptom sequence Sequencing spread to the mean the SARS-CoV-2 Transmission variant virus virus transmission was determined was used whole genome [DOI] 10.1371/journal.pone.0276696 PMC 바로가기
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기
SARS-CoV-2 specific antibody trajectories in mothers and infants over two months following maternal infectionArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] Adults anti-SARS-CoV-2 antibody Blood Breastfeeding children close contact collected Comparative concentrations conducted control group COVID COVID-19 COVID-19 infection dried blood spot IgA IgG incidence of COVID-19 infancy Infant Infants infected with SARS-CoV-2 Infection infection risk intensive care likelihood mother Neonatal Older outcome PCR positivity pediatric positive Probability reported Research Result returned risk S-RBD SARS-CoV-2 SARS-COV-2 infection Support Symptom tested the mean trajectory [DOI] 10.3389/fimmu.2022.1015002 PMC 바로가기
Estimation of biochemical factors affecting survival in intensive care COVID-19 patients undergoing chest CT scoring: A retrospective cross-sectional studyArticle Published on 2022-10-072022-11-16 Journal: Medicine [Category] 변종, [키워드] 95% CI Affect affecting age APACHE II APACHE II score approval biochemical Blood urea nitrogen changed Chest computed tomography Chest CT chest CT scan conducted Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Data analysis determine died estimation ethics committee Factor faculty females Follow-up greater Health ICU intensive care Invasive mechanical ventilation laboratory parameter males marker Mortality mortality rate no significant difference nonsurvivor nonsurvivors pandemic Patient PCR PCR test polymerase chain positive Prognosis ranged Respiratory disease Retrospective cross-sectional study significantly SPSS survival survivor symptomatic patient the mean the patient the WHO Transmission university variant was used were recorded widespread window Wuhan [DOI] 10.1097/MD.0000000000030407 PMC 바로가기
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infectionArticle Published on 2022-10-032022-11-15 Journal: Virology Journal [Category] 치료제, [키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used [DOI] 10.1186/s12985-022-01885-0 PMC 바로가기
Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approachArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis applied approach calibrated candidate carried clinical Clinical efficacy clinical trial convalescent CoronaVac COVID-19 COVID-19 pandemic COVID-19 vaccine develop Efficacy humans immunogenicity data Inc. joint literature review LLC Meta-analysis Model-based meta-analysis (MBMA) modelling Modelling and simulation Neutralizing predict predicted Predictive Predictive model Quantitative reported rhesus macaque Safe SARS-CoV-2 SARS-CoV-2 vaccines serum Sharp strain Study design Support systematic literature search the mean titre translation translational USA vaccination Vaccine vaccine candidate Vaccines variant Viral load were used [DOI] 10.1016/j.ebiom.2022.104264 PMC 바로가기
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication
Performance of nasopharyngeal swab and saliva in detecting Delta and Omicron SARS-CoV-2 variantsDelta 및 Omicron SARS-CoV-2 변이체 검출 시 비인두 면봉 및 타액의 성능Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Chain Reaction characterized conducted coronavirus cough COVID-19 Delta diagnostic Dyspnea epidemic wave epidemic waves expressed highest increase in Infection Laboratory log molecular nasopharyngeal Nasopharyngeal swab no significant difference not significant NP swab NP swabs NPs nucleic acids omicron participant Participants Patient performance polymerase chain polymerase chain reaction processing prospective cohort study real-time RT-PCR reported required respiratory rhinorrhea RNA Saliva saliva samples Sample SARS-CoV-2 SARS-CoV-2 diagnostics SARS-CoV-2 epidemic SARS-CoV-2 variant significant difference sore sore throat specimen specimen collection statistically Symptom Symptoms thawing the mean transported Viral Viral load [DOI] 10.1002/jmv.27898 PMC 바로가기 [Article Type] Article
Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort StudyResearch article Published on 2022-10-012022-10-05 Journal: Journal of psychiatric research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] age agency And personality Anxiety anxiety symptoms association average baseline Capital class condition COVID COVID-19 COVID-19 cohort COVID-19 pandemic Depression element ENhance finding Health health condition increase increase in individual individuals initial Latent less maintain mental health MOST number of symptom obesity Odds ratio predicted Probability ranged receive reported reporting symptom Research resource Result socioeconomic status subsequent Symptom symptoms of depression the mean trajectory unlikely were used [DOI] 10.1016/j.jpsychires.2022.07.011 [Article Type] Research article