SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategyDNA 프라임-단백질 부스트 전략을 이용한 SARS-CoV-2 변이체 감염에 대한 고친화성 단일클론항체 유도Article Published on 2022-06-092022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha alpha and delta variants angiotensin angiotensin-converting enzyme 2 animals Antibody titers approach approved best Beta Beta variant binding ability binding affinity boost broad spectrum clone coronavirus Coverage COVID-19 COVID-19 vaccination D614G Delta delta variant DNA ELISA Emergency use Endemic epitope epitope mapping Epitopes evaluated exhibit flu Gamma generate high affinity Human angiotensin-converting enzyme 2 include induction Infection Lambda monoclonal antibodies monoclonal antibody monoclonal antibody combination Multiple neutralization neutralization potency neutralize Neutralizing antibody titer neutralizing capacity neutralizing epitope neutralizing epitopes Outbreaks PROTECT RBD Receptor-binding domain regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Spike protein the receptor-binding domain the spike protein therapeutic drug therapeutic effect therapeutic effects treat treated Treatment variant variants VoC VOCs were used Wuhan strain [DOI] 10.1186/s12929-022-00823-0 PMC 바로가기 [Article Type] Article
Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질을 표적으로 하는 새로운 인간 항체의 구조 유도 친화성 성숙Article Published on 2022-05-192022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation antibody binding biological function BLI candidate complex conserved Diagnosis diagnostic effective Evidence expected genome sequence global pandemic higher affinity homology Interaction linker magnitude marker molecular docking mutant Mutation N protein nucleocapsid protein pandemic peptide predicted Prevention and control Protein recent recognize residue SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-CoV-2 pandemic scFv shown Structure the N protein the SARS-CoV-2 therapeutic drug Treatment was tested [DOI] 10.1038/s41598-022-12242-0 PMC 바로가기 [Article Type] Article
The impact of COVID-19 on pregnancy and therapeutic drug development코로나19가 임신과 치료제 개발에 미치는 영향Review Published on 2022-05-012022-09-11 Journal: British Journal of Pharmacology [Category] 신약개발, [키워드] age anniversary approach article baby benefit cardiovascular disease cardiovascular diseases clinical study clinical trial clinical trials Community COVID COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines disorder disorders Drug development drug treatment drug treatments during pregnancy eclampsia Effect generate Healthcare provider healthcare providers Humoral immunity hypertensive Hypothesis knowledge lactating women life management mother offer offered outcome pre-eclampsia Pregnancy pregnant pregnant women risk robust second wave significantly higher subsequent supported therapeutic drug Trial vaccination Vaccine Vaccines with COVID-19 women [DOI] 10.1111/bph.15582 PMC 바로가기 [Article Type] Review
Rapid Assay for the Therapeutic Drug Monitoring of EdoxabanEdoxaban의 치료 약물 모니터링을 위한 신속한 분석Article Published on 2022-04-172022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile administration Anticoagulant blood plasma Care Concentration detect DOAC drug edoxaban followed by hotspot HPLC indicated lab limit lowest methanol monitoring pathology Patient pharmacokinetic Pulmonary embolism quantification R 2 Raman spectroscopy Rapid receiving reporter Safe SARS-CoV-2 infections standard sample standard samples surface enhanced Raman spectroscopy therapeutic therapeutic drug Therapeutic Drug Monitoring therapeutic index thiol Treatment Variability was used [DOI] 10.3390/biom12040590 PMC 바로가기 [Article Type] Article
Mechanisms of action of fluvoxamine for COVID-19: a historical reviewReview Published on 2022-04-012022-10-04 Journal: Molecular Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] accelerate acute respiratory syndrome caused Clinical data coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic death disorder Drug repurposing Increasing intubation mechanism Mild moderate Neuropsychiatric offspring pandemic Prophylactic receptor reduced risk risk SARS-CoV-2 Schizophrenia Serotonin subject therapeutic drug virus with COVID-19 [DOI] 10.1038/s41380-021-01432-3 PMC 바로가기 [Article Type] Review
Review of selected animal models for respiratory coronavirus infection and its application in drug researchReview Published on 2022-03-242022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis animal animal model animal models Characteristics Clinical features Clinical signs coronavirus Coronavirus infection Disadvantages disease drug Efficacy evaluate ferrets function hamsters Histopathology include Infection information limitations management mechanism mice New Novel coronavirus Numerous pathogen Pathogenesis reported Research Respiratory Coronavirus review SARS‐CoV‐2 SARS‐CoV‐2 selected Strains susceptible therapeutic drug Transmission Vaccines Viral pneumonia viral replication virus virus replication Wuhan [DOI] 10.1002/jmv.27718 PMC 바로가기 [Article Type] Review
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19 Research Published on 2022-03-212022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome age alteration anti-SARS-CoV-2 blockade contributed coronavirus Coronavirus disease 2019 COVID-19 dendritic cell effective Efficacy eicosanoid elevated expression Human immune pressure indicate Intervention Isolation lethal infection mice mononuclear cells mouse-adapted SARS-CoV-2 mRNA expression murine outcome pathway Peripheral blood PGD2 Phospholipase A2 PLA2G2D populations prostaglandin D2 PROTECT PTGDR receptor required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe COVID-19 severe disease severity the spike protein therapeutic drug therapeutic interventions Therapies Treatment Vaccine variant virulent virus [DOI] 10.1038/s41586-022-04630-3 [Article Type] Research
Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients아달리무맙과 인플릭시맙은 SARS-CoV-2 항체 반응을 손상시킨다: 생물학적 치료를 받은 11,422명의 환자를 대상으로 한 치료 약물 모니터링 연구의 결과Article Published on 2022-03-142022-09-11 Journal: Journal of Crohn's & colitis [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] adalimumab anti-TNF antibody reactivity Antibody Response Antibody testing attenuate biologic bowel causal relationship CLARITY combination therapy confounding factors COVID-19 cut-off detectable drug drug level drug levels drugs Immune-mediated inflammatory diseases immunomodulator Immunosuppression Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab influence Laboratory magnitude median median age median time monitoring Necrosis Patient patients PCR testing PCR-confirmed positive Rate reactivity responses Result SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR seroconvert serological serological response seropositive Seropositivity Seroprevalence serum Support therapeutic drug Therapeutic Drug Monitoring treated Treatment treatment groups undetectable vaccination vedolizumab were measured [DOI] 10.1093/ecco-jcc/jjab153 PMC 바로가기 [Article Type] Article
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients통합 멀티오믹스 및 in silico 분석은 경증 및 중증 COVID-19 환자에서 ARHGEF1 및 선별된 길항제의 역할을 밝혔습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anticancer Antiviral ARHGEF1 association Biotechnology caused center co-expression co-expression network Compound computational tool computational tools coronavirus COVID-19 database DEGs determine differentially expressed gene Differentially expressed genes disease effective therapy ENhance enrichment expressed expression profile gene co-expression network Gene ontology group guanine identify in silico analysis In silico methods in vitro in vivo infected patients inherent Medicines messenger Messenger RNA Mild molecular molecular docking molecular dynamics MSI-DEGs nucleotide number of infected Ontology overlapping pathogenic pathway patients worldwide protein-protein interaction rapid increase required Research SARS-CoV-2 SARS-CoV-2 patients screened severe acute respiratory syndrome Coronavirus severe COVID-19 patient Severity of infection stratified target therapeutic drug therapeutic efficacy therapeutic target therapy virus [DOI] 10.1002/jcb.30213 PMC 바로가기 [Article Type] Article