An Updated Review of Computer-Aided Drug Design and Its Application to COVID-19컴퓨터 보조 약물 설계에 대한 업데이트 된 검토 및 Covid-19에 대한 적용Review Published on 2021-06-242022-09-10 Journal: BioMed Research International [Category] 신약개발, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 application approved drug approved drugs artificial intelligence category clinicians and researcher computer-aided drug design coronavirus coronavirus disease COVID-19 drug drug candidate drug design Drug discovery drug target fatal disease Health help helping highlight implicated include involved lack management molecular molecular docking outbreak pandemic Pathogenesis pharmacological Quantitative researcher respiratory review SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapeutic molecules Vaccine [DOI] 10.1155/2021/8853056 PMC 바로가기 [Article Type] Review
Multi-Omics Approach in the Identification of Potential Therapeutic Biomolecule for COVID-19Pharmacology Published on 2021-05-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis approach Biomolecule biomolecules can be used caused contagious coronavirus COVID-19 disease drug effective Health identification identify Medicine metagenome molecular mechanism Multi-omics offer overcome plant Potential producing proteome SARS-CoV-2 sequence Spread therapeutic Therapeutic compounds Therapeutic molecule therapeutic molecules treating SARS-CoV-2 infection Treatment Vaccine virus whole-genome sequencing [DOI] 10.3389/fphar.2021.652335 PMC 바로가기 [Article Type] Pharmacology
Probiotic-Based Vaccines May Provide Effective Protection against COVID-19 Acute Respiratory DiseaseReview Published on 2021-05-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addition adjuvants Administered administration approach Cell-mediated immune responses clinical information codon usage concern coronavirus COVID-19 cross-talk dose Effectiveness elicit Emergency expression level highlight IgA antibody immune response immune responses immune system induce Infection infections microorganism microorganisms modulating modulation mucosal mucosal immune Mucosal immunization mucosal route nasal neutralize previous study Probiotics Prospective Study protection Protective Public respiratory responses SARS-CoV-2 SARS-COV-2 infection serum IgG shown Therapeutic molecule therapeutic molecules therapy transmitted Vaccine development Vaccines vectors virus viruses WHO World Health Organization [DOI] 10.3390/vaccines9050466 PMC 바로가기 [Article Type] Review
Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19COVID-19를 치료하기 위한 치료 전략으로 SARS-CoV-2 바이러스 프로테아제 표적화Review Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] 3 chymotrypsin-like cysteine protease 3CL pro acute respiratory syndrome Amino acid caused chymotrypsin coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus main protease COVID-19 COVID-19 infection CoVs cysteine cysteine protease death Epidemic Infection information MERS Middle East Middle East respiratory syndrome outbreak Papain papain-like cysteine protease. Papain-like protease protease Protein SARS Coronavirus SARS infection SARS-CoV SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome similarity Spread Support syndrome targeting the United State Therapeutic molecule therapeutic molecules therapeutic strategy treat treatment strategy United States Viral proteins virus [DOI] 10.1002/jmv.26814 PMC 바로가기 [Article Type] Review
Remdesivir: Critical Clinical Appraisal for COVID 19 Treatment렘데시비르: COVID 19 치료에 대한 중요한 임상 평가Review Published on 2021-03-012022-09-11 Journal: Drug research [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] appraisal approved authorization clinical Clinical research Clinical studies clinical trial conducted COVID 19 COVID19 effective Emergency Hope In-vitro information mechanism MERS molecule Regulatory Remdesivir Research therapeutic molecules Usage virus [DOI] 10.1055/a-1288-4078 PMC 바로가기 [Article Type] Review
Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African OriginArticle Published on 2021-01-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] acute respiratory syndrome African African natural products antiviral drug approach approved AutoDock binding energy binding mechanism biological activity caused Cell characterized complexes Compound computation coronavirus coronavirus disease COVID-19 Critical de novo drug identification impacted in vitro inhibit inhibitor inhibitors membrane integrity membrane permeability MM/PBSA molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations natural novel origin outcome pandemic pharmacological Potential predicted profile protease Protein protein-ligand public health receptor receptors Replication residue RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 inhibitors screened target the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic molecules Toxicity viral entry Virtual screening virus [DOI] 10.3390/molecules26020406 PMC 바로가기 [Article Type] Article
Food and COVID-19: Preventive/Co-therapeutic Strategies Explored by Current Clinical Trials and in Silico StudiesReview Published on 2020-08-012022-11-01 Journal: Foods [Category] COVID-19, [키워드] acting acute respiratory syndrome carrier clinical clinical trial component components Compound compounds coronavirus coronavirus disease COVID-19 COVID-19 pandemic current enhancer etiological agent food functional Health Host immune system in silico in silico study in vitro in vivo infective Interaction interfere knowledge micronutrient Clinical trial micronutrients pandemic promote protein interaction Research SARS-CoV-2 Strategy target the SARS-CoV-2 therapeutic molecules Therapies virus [DOI] 10.3390/foods9081036 PMC 바로가기 [Article Type] Review