Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine
나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다
Article
Published on
Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단,
Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단,
[키워드] activated
Adaptive immune response
adjuvant
adjuvants
agonist
Anti-spike
anti-Spike IgG
Antibody titer
Antibody titers
Antigen
antigen-presenting cell
antigen-presenting cells
APC
APCS
B cell
B cells
BAL
Bcl6
Blood
bronchoalveolar
CD4
CD44
Cell
cell population
characterized
Combination adjuvant
COVID-19
COVID-19 protein subunit vaccine
CpG
DLNs
draining lymph node
draining lymph nodes
Efficacy
ENhance
follicular
Germinal center
GL7
helper cell
humoral immune responses
IgA
IgG
immune
immune response
immune responses
Immunity
IMPROVE
in vitro
in vivo
Increases
increases in
Infection
intramuscular
intramuscular vaccination
intranasal
Intranasal versus intramuscular vaccination
intranasally
lead
lung
Lungs
lymphocyte
memory T
memory T cell
mice
molecular
Monophosphoryl lipid A
MPLA
Native
neutralizing antibody titers
Pattern recognition
pattern recognition receptor
Pattern recognition receptors
Polymer
Population
Proinflammatory cytokine
Protein subunit
protein subunit vaccine
Protein subunit vaccines
PRR
PRRs
PUUC
reaction
receptor
receptors
responses against
retinoic acid
retinoic acid-inducible gene I
RIG-I
robust
S1 subunit
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike protein
secretion
spike IgA
Spike protein
stabilized spike protein
stimulate
subunit
Subunit vaccine
T cell
T cell proliferation
the S1 subunit
TLR
TLR4
TLR7
TLR7/8
TLR9
TLRs
Toll-like receptor
Toll-like receptors
Transmission
unique
Vaccine
vaccine availability
vaccine responses
variants
[DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article