Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19Review Published on 2021-07-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] addition Apoptosis ATP autophagy cause cell death cellular consequence coronavirus COVID-19 decrease drug enzyme event facilitate infections inhibit innate immune involved knowledge membrane metabolism Mitochondria mitochondrial modulate MPTP NLRP3 inflammasome organelle pathway Pathways potential targets proliferation ROS SARS-CoV2 shift Signaling Stress target therapeutic target therapy treat UPR viral infection viral infections viral proliferation virus viruses [DOI] 10.3390/ijms22158180 PMC 바로가기 [Article Type] Review
Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection전개된 단백질 반응의 조작: 코로나바이러스 감염에 대한 약리학적 전략Research Article Published on 2021-06-172022-09-10 Journal: PLoS Pathogens [Category] 진단, 치료제, [키워드] activate activated Activation antiviral target ATF6 Betacoronavirus Betacoronavirus genus Cancer cellular cellular response chronic respiratory disease composed coronavirus Coronavirus infection Coronavirus replication COVID-19 COVID-19 pandemic develop died Diseases drug Endoplasmic reticulum ENhance fold genetic information highlight human lung cells in some induce infected cells Infection inhibited inhibitor manipulation medication MHV Mild mild to moderate moderate Modification MOST murine hepatitis virus neurodegenerative disorder neurodegenerative disorders Novel coronavirus Older ORF8 over-expression pathway pharmacological problem Protein protein levels reduce reduced reducing replicate Replication respiratory Respiratory disease Respiratory illness responsible RNA sequencing S protein S proteins SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells significantly the Betacoronavirus the SARS-CoV-2 these compound these compounds These data transcriptional translational Treatment triggered unfolded protein response up-regulated UPR viral disease Viral protein Viral proteins virion virus [DOI] 10.1371/journal.ppat.1009644 PMC 바로가기 [Article Type] Research Article
Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other CoronavirusesSARS-CoV-2 감염에서 자가포식, 전개된 단백질 반응 및 뉴로필린-1 상호작용: 다른 코로나바이러스로부터 배울 수 있는 것Review Published on 2021-06-012022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, 치료제, [키워드] ACE2 activate acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Apoptosis arms race autophagy benefit binding Can caused cell surface receptors cellular cellular response Cellular responses cellular stress response cellular stress responses clearance Coronavirus infection COVID-19 COVID-19 complication COVID-19 complications COVID-19 infection COVID-19 mortality COVID-19 pandemic cytokine Cytokine storm DCs dendritic cell dendritic cells effort endoplasmic reticulum stress ENhance enzyme evolutionary arms race gastrointestinal complication gastrointestinal complications generate health emergency help host cell host cells humans identify immune system increase induce infected cells Infection Innate immunity involved mechanism modulation Mortality mTOR neuropilin Neuropilin-1 NRP1 Other pathogen Pathogens pathway Pathways potential therapeutic target potential therapeutic targets reduce regulated Regulation required respiratory response SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection signaling pathway specific treatment stress responses susceptibility tissue homeostasis Treatment unfolded protein response UPR Viral viral infection Viral particles virus virus infection viruses [DOI] 10.3390/ijms22115992 PMC 바로가기 [Article Type] Review
The Unfolded Protein Response and Autophagy on the Crossroads of Coronaviruses Infections코로나바이러스 감염의 교차로에서 펼쳐진 단백질 반응과 자가포식Review Published on 2021-04-282022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] addition autophagy autophagy machinery balance calcium cell death cellular cellular components cellular response Chloroquine component components conserved coronavirus Coronavirus infection CoV debatable debate Degradation drug Each Efficacy Endoplasmic reticulum environmental condition environmental conditions eukaryotic cell eukaryotic cells function functions generate highlighting homeostasis host-pathogen interaction in some include increasingly Infection infections instance integrated stress response involved matter mechanism modulate molecular interaction molecular mechanism molecular mechanisms niclosamide outcome pathway Pathways Perturbation perturbations promote Protein redox status replicative respond response SARS-CoV-2 pandemic signaling pathway spermine Stress suggested Support survival therapeutic options Topic Transcription translation unfolded protein response UPR Vesicle Viral viral infections viral replication virus viruses [DOI] 10.3389/fcimb.2021.668034 PMC 바로가기 [Article Type] Review
Repurposing approved drugs for cancer therapy암 치료를 위해 승인된 약물의 용도 변경Review Published on 2021-03-252022-08-31 Journal: British medical bulletin [Category] 신약개발, 유전자 메커니즘, [키워드] Abivertinib activities adverse event adverse events alterations anti-inflammatory compounds approved approved drug approved drugs Area Better can be used can not Cancer Cancer therapy chemotherapeutics Chemotherapy chromosome clinical trial clinical trials Covid-19 adjuvant treatments cytokine Cytokine storm Cytokines cytotoxicity diabete diabetes drug drug activity drug combinations drugs ENhance ER stress growth help IFN IL-2 IL-6 indication induce Inflammation inhibitor inhibitors interferon interferons interferons (IFN) interleukin interleukin-2 interleukin-2 (IL-2) interleukin-6 Kinase inhibitor kinase inhibitors knowledge limit literature mechanism metabolism metformin Mutation mutation rate Mutation rates Necrosis Patient proteolysis proteosome inhibitors receptor inhibitors reducing repurposing Side effect Side effects Symptom target gene thalidomide TNF treat Treatment Tumor tumor cell tumor cells tumor necrosis tumor necrosis factor tumor necrosis factor (TNF) tumorigenesis tumors tyrosine tyrosine kinase inhibitor unfolded protein response unfolded protein response (UPR). UPR [DOI] 10.1093/bmb/ldaa045 PMC 바로가기 [Article Type] Review
Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2Review Published on 2021-02-222022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] addition Apoptosis association Autoimmune Autoimmunity Cell chaperone chaperones contribute coronavirus COVID-19 Degradation Effect Endoplasmic reticulum ENhance epitope ER stress Evidence expression Factor Gene Expression heat shock protein Host Hsps immune system include increase in induce infect Infection Interaction macromolecules molecular Necrosis network Part Protein protein synthesis Proteins proteolytic Proteostasis Reactions replicate SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 Spread Stress target cells unfolded protein response UPR viral infection Viral protein virus [DOI] 10.1186/s12575-021-00145-9 PMC 바로가기 [Article Type] Review
Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and InhibitionMicrobiology Published on 2020-10-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] affected Antiviral Apoptosis autophagy cascade change changes Community components COVID-19 death demonstrated detection diagnostics dissemination Endoplasmic reticulum Epidemiology Epigenetic event Genetic genetics and epigenetics global pandemic highlight host cell host’s immune response Inflammasome inhibition medications molecular mortality rate nanobased diagnosis nanobased therapeutics Nanotechnology outbreak Probability Prospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Scientific community Stress target cells the SARS-CoV-2 therapeutic options unfolded protein response UPR viral infection viral replication viral-induced Worldometer [DOI] 10.3389/fmicb.2020.02098 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAsArticle Published on 2020-09-012023-06-14 Journal: American journal of physiology. Lung cellular and [Category] MERS, SARS, [키워드] Coronavirus disease 2019 (COVID-19) Coronaviruses miRNA sponges SARS-CoV UPR [DOI] 10.1152/ajplung.00252.2020 PMC 바로가기
Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeuticsReview Published on 2018-08-072023-08-29 Journal: Oncotarget [Category] E형 간염, [키워드] ATF6 endoplasmic reticulum stress IRE1α PERK UPR [DOI] 10.18632/oncotarget.25886 PMC 바로가기 [Article Type] Review
Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functionsArticle Published on 2018-05-222024-09-04 Journal: Toxicology and applied pharmacology [Category] 대상포진, [키워드] Apoptosis arsenic ATF4 macrophage functions UPR [DOI] 10.1016/j.taap.2016.07.015 PMC 바로가기 [Article Type] Article