upregulated gene – Page 2 – Communicable Diseases Research

An integrative analysis identifying transcriptional features and key genes involved in COVID-19

COVID-19와 관련된 전사적 특징과 핵심 유전자를 식별하는 통합 분석

Research Article

Published on 2020-11-262022-09-11
Journal: Epigenomics [Category] SARS, 유전자 메커니즘, 진단,

Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection

Article

Published on 2020-06-092022-10-31
Journal: Cells [Category] Coronavirus,

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells

Research Article

Published on 2017-03-292022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions Zoonotic coronavirus
[DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin
[DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article