Functional-genomic analysis reveals intraspecies diversification of antiviral receptor transporter proteins in Xenopus laevis기능 게놈 분석은 Xenopus laevis에서 항바이러스 수용체 수송체 단백질의 종 내 다양화를 보여줍니다Research Article Published on 2021-05-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African African clawed frog Analysis Antiviral assays clade described effector Evolution expression family functional G-protein homolog identify immune immune stimulation independent Infection inhibit Innate immunity involved knowledge less mammal Mammalia mammalian mammals MOST Olfaction olfactory physiological Positive selection Protein receptor regulate reveal RNA sequencing RNA viruses Signaling transporter upregulated vertebrates Viral viral infection Xenopus [DOI] 10.1371/journal.pgen.1009578 PMC 바로가기 [Article Type] Research Article
Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS‐CoV‐2Research Article Published on 2021-05-192022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] 3D structure ACE2 acute respiratory syndrome Amino acid Analysis binding calculated Comparative Contact coronavirus coronavirus disease enzyme Fisher exact test Genome human ACE2 humans hydrophobic Infection lack less livestock occur Outbreaks Probability receptor residue risk SARS‐CoV‐2 SARS‐CoV‐2 searched selected Seven susceptibility susceptible TMPRSS2 TMPRSS2 protease Transmission Vertebrate vertebrates virus [DOI] 10.1002/jmv.27073 PMC 바로가기 [Article Type] Research Article
In-silico approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel인간 중증 급성 호흡기 증후군 코로나바이러스 외피 단백질 이온 채널의 억제제를 검출하기 위한 인-실리코 접근법Article Published on 2021-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료기술, [키워드] Absorption acute respiratory syndrome amino acids approach binding caused computational approach Computational approaches coronavirus coronavirus disease Coronaviruses COVID-19 detect disease docking drug E protein envelope protein enveloped virus excretion help humans inhibit inhibitor Interaction ion channel metabolism modeling modulate molecular molecular dynamics outbreak pandemic Pathogenesis Protein quest random recent reduced reported Result rule SARS-CoV2 Severe acute respiratory syndrome Toxicity turn vertebrates virus α-helix [DOI] 10.1080/07391102.2020.1751300 PMC 바로가기 [Article Type] Article
Interacting Proteins, Polymorphisms and the Susceptibility of Animals to SARS-CoV-2Review Published on 2021-03-122022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] ACE2 affecting Alter Analysis angiotensin-converting enzyme 2 animal approach assist bats caused Cell cells change Contact contribute country COVID-19 disease Evidence furin future work help highlight host cells Human human disease humans Interaction likelihood management Measures Neuropilin-1 Observational data pandemic Polymorphisms populations Protein Proteins receptor risk Safe SARS-CoV-2 sequence Sequence analysis simple Support susceptibility susceptible the disease the SARS-CoV-2 virus thought TMPRSS2 TMPRSS2 protein transmitted utility vertebrates virus WHO wild animals [DOI] 10.3390/ani11030797 PMC 바로가기 [Article Type] Review
Oligomannose N -Glycans 3D Architecture and Its Response to the FcγRIIIa Structural LandscapeArticle Published on 2021-03-042022-10-29 Journal: The journal of physical chemistry. B [Category] Coronavirus, SARS, [키워드] 3D structure ADCC antibody-dependent cellular cytotoxicity architecture Arm binding affinity complex conformation conformational cumulative Effect experimental evidence FcγRIIIa feature form function glycan glycosylated glycosylation HIV-1 IgG1 Immune escape intrinsically involved landscape mammalian Man modulate molecular processed promote Protein receptor response SARS-CoV2 steric Structure Support vertebrates viruses yeast [DOI] 10.1021/acs.jpcb.1c00304 PMC 바로가기 [Article Type] Article
Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 InfectionReview Published on 2020-11-072022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE ACE inhibitors ACE2 activity adverse effects anti-hypertensive drug biological activity C-terminus cardiometabolic cardiometabolic syndrome cardiovascular cells compounds COVID-19 COVID19 drug enzyme examined Factor hydrophobic hypertension hypertensive patients in sight Infection prevention inhibitory inhibitory activity invertebrates involved marine peptides microorganism Mild modulation molecular mechanism New New coronavirus organism origin pandemic peptide peptides Potential prevention RAAS raised receptor renin-angiotensin-aldosterone system residue resource responsible role SARS-CoV-2 sea organisms syndrome System therapeutic agent treat vertebrates virus [DOI] 10.3390/ijms21218364 PMC 바로가기 [Article Type] Review
COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoproteinDiscovery Notes Published on 2020-10-162022-10-28 Journal: Biology Direct [Category] COVID-19, Fulltext, SARS, [키워드] binding cause connection coronavirus coronavirus spike protein COVID-19 cysteine cytoplasmic tail ectodomain Ferroportin hepcidin homology host cell surface Human IL-6 Inflammation Inflammatory iron Local metabolism Novel coronavirus observation Protein Pufferfish question receptors Regulation Research respiratory infection sequence similarity spike glycoprotein Spike protein the SARS-CoV-2 virus the spike protein thought transmembrane region Vaccine vertebrates viral spike protein [DOI] 10.1186/s13062-020-00275-2 PMC 바로가기 [Article Type] Discovery Notes
Immunoglobulin M: An Ancient Antiviral Weapon – RediscoveredImmunology Published on 2020-08-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] acquisition adaptive antibody Apoptosis asymmetric Cancer cells Cell Evolution host protein IgM IgM function IgM structure Immunity immunization immunodeficiency virus Immunoglobulin include Influenza virus inhibitor Macrophage monomer mucosal murine models non-human primates passive mucosal immunization with IgM pathogen invasion Pathogens Plasma cell preserved Prevent prevention of mucosal virus transmission by IgM produced promote raise recent recombinant monoclonal IgM released respond second shown Somatic hypermutation spleen thought Transmission Vaccine vaccine-induced long-lived IgM plasma cells vertebrates virus weapon [DOI] 10.3389/fimmu.2020.01943 PMC 바로가기 [Article Type] Immunology
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein점 돌연변이는 마이크로솜 트리글리세리드 전달 단백질의 지질 전달 활동을 분리합니다Research Article Published on 2020-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect ApoB ApoB-containing lipoprotein ApoB-containing lipoproteins Apolipoprotein B Apolipoprotein B-containing lipoprotein Apolipoprotein B-containing lipoproteins assembly B-lp B-lps bind block blood vessels cardiovascular cardiovascular disease circulation complex conserved Critical crystal structure cytoplasmic lipid droplet cytoplasmic lipid droplets disease Disruption drug design dyslipidemia dyslipidemias Embryo endogenous lipid fat malabsorption feasible G863V G863V mttp mutant protein G863V mutant protein glycine growth growth defects growth retardation growth retardation) health condition heterodimeric highlight Human human MTP humans hydrophobic identify inhibitor insect Insects intestinal fat malabsorption L475P Lipid lipid transfer activity lipids Lipoproteins metabolism microsomal triglyceride transfer protein Missense mutation modeling morphology Mtp MTP complex MTP triglyceride transfer activity MTTP mutant mutants Mutation opacity phenotype Phospholipids plasma lipoproteins Point mutation power Prevent Protein reduce reported required residue secretion selective selective inhibition Support synthesis Therapeutic approach These data tissues transfer Transport treat Triglyceride triglycerides valine vertebrates wall yolk yolk opacity yolk syncytial layer YSL zebrafish [DOI] 10.1371/journal.pgen.1008941 PMC 바로가기 [Article Type] Research Article
TRPV4: A Physio and Pathophysiologically Significant Ion ChannelReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] animal model channel clinical trial Consequences disease dysfunction Evidence highlight Human invertebrate Ion pathophysiological physiological Potential Protein receive Significant Structure therapeutic target Transient TRP TRP channels TRPV1 TRPV4 variety vertebrates [DOI] 10.3390/ijms21113837 PMC 바로가기 [Article Type] Review